4.6 Article

Microglia induce auditory dysfunction after status epilepticus in mice

Related references

Note: Only part of the references are listed.
Article Cell Biology

Microglia enable cross-modal plasticity by removing inhibitory synapses

Akari Hashimoto et al.

Summary: Cross-modal plasticity refers to the repurposing of brain regions to improve other sensory modalities. In this study, it was found that visual deprivation induced cross-modal plasticity by rewiring the microglia-mediated local circuit synapse. This resulted in enhanced excitatory responses in the secondary lateral visual cortex (V2L) during whisker stimulation and improved vibrissae sensory discrimination. The enhanced cross-modal response was achieved by the selective removal of inhibitory synapse terminals on pyramidal neurons by microglia via the matrix metalloproteinase 9 signaling pathway. These findings provide insights into how cortical circuits integrate different inputs to compensate for neuronal damage.

CELL REPORTS (2023)

Review Cell Biology

Microglia regulation of synaptic plasticity and learning and memory

Jessica Cornell et al.

Summary: Microglia are resident macrophages of the central nervous system with diverse morphologies and functions. Resting microglia play a crucial role in regulating synaptic pruning and neuronal activity under normal conditions, while activated microglia secrete proteins that can lead to synaptic plasticity and cognitive deficits associated with various diseases and disorders. This review discusses the role of microglia in synaptic plasticity and learning and memory, as well as the potential of manipulating microglia as a therapeutic approach to alleviate cognitive deficits.

NEURAL REGENERATION RESEARCH (2022)

Review Clinical Neurology

Epilepsy With Auditory Features: From Etiology to Treatment

Alessandro Furia et al.

Summary: Epilepsy with auditory features (EAF) is a focal epilepsy characterized by seizures with auditory aura or receptive aphasia, suggesting involvement of the lateral temporal lobe. The etiology of EAF is largely unknown, but familial and sporadic cases share similar clinical characteristics with only a few having a documented genetic cause. Patients with EAF usually have a normal neurological examination and respond well to antiseizure medications. However, remission rates may be lower than expected and treatment withdrawal can lead to relapses.

FRONTIERS IN NEUROLOGY (2022)

Article Multidisciplinary Sciences

Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization

Tabitha R. F. Green et al.

Summary: The choice of method for quantifying microglial morphology is critical as it can bias results. This study compared five commonly used methods and found significant discrepancies among them. Selection of quantitative methods for analyzing microglial morphology should be based on multiple criteria, and combining methods may provide a more accurate representation of microglial morphology.

SCIENTIFIC REPORTS (2022)

Review Developmental Biology

Microglia regulate synaptic development and plasticity

Megumi Andoh et al.

Summary: Synapses are fundamental structures that transmit information between neurons in neural circuits. Proper synaptic connections shape the basis of brain functions and animal behavior. Microglia play important roles in regulating synaptic function, and the underlying molecular mechanisms have been thoroughly studied.

DEVELOPMENTAL NEUROBIOLOGY (2021)

Review Neurosciences

The Kainic Acid Models of Temporal Lobe Epilepsy

Evgeniia Rusina et al.

Summary: Experimental models of epilepsy, particularly the kainic acid model, offer researchers a rich variety of phenotypes that can help in understanding the mechanisms and potential treatments of temporal lobe epilepsy. The different modes of KA administration produce varied effects and outcomes, highlighting the importance of considering strain, species, gender, and age factors in research. Additional work is needed to fully explore the potential of KA models in epilepsy research.

ENEURO (2021)

Article Neurosciences

Microglia attenuate the kainic acid-induced death of hippocampal neurons in slice cultures

Tasuku Araki et al.

NEUROPSYCHOPHARMACOLOGY REPORTS (2020)

Review Biochemistry & Molecular Biology

Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

Richard Fairless et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Medicine, General & Internal

Synaptic Pruning by Microglia in Epilepsy

Megumi Andoh et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Audiology & Speech-Language Pathology

Subcortical pathways: Towards a better understanding of auditory disorders

Richard A. Felix et al.

HEARING RESEARCH (2018)

Article Multidisciplinary Sciences

Quantifying Microglia Morphology from Photomicrographs of Immunohistochemistry Prepared Tissue Using ImageJ

Kimberly Young et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

Review Cell Biology

Microglia after Seizures and in Epilepsy

Toshimitsu Hiragi et al.

CELLS (2018)

Review Biotechnology & Applied Microbiology

Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients

Lucia Wittner et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Immunology

Dynamic microglial modulation of spatial learning and social behavior

Luisa Torres et al.

BRAIN BEHAVIOR AND IMMUNITY (2016)

Article Multidisciplinary Sciences

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Angela Kolodziej et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)

Article Biochemical Research Methods

Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging

Etsuo A. Susaki et al.

NATURE PROTOCOLS (2015)

Article Neurosciences

Exploring functions for the non-lemniscal auditory thalamus

Charles C. Lee

FRONTIERS IN NEURAL CIRCUITS (2015)

Article Multidisciplinary Sciences

The Effects of Exercise on Synaptic Stripping Require Androgen Receptor Signaling

Caiyue Liu et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Zhihong Chen et al.

NATURE COMMUNICATIONS (2014)

Review Behavioral Sciences

The kainic acid model of temporal lobe epilepsy

Maxime Levesque et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

Article Clinical Neurology

Common mechanisms of auditory hallucinations-perfusion studies in epilepsy

Martinus Hauf et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2013)

Article Behavioral Sciences

Central auditory processing impairment in patients with temporal lobe epilepsy

Myung Woul Han et al.

EPILEPSY & BEHAVIOR (2011)

Article Audiology & Speech-Language Pathology

Physiological differences between histologically defined subdivisions in the mouse auditory thalamus

Lucy A. Anderson et al.

HEARING RESEARCH (2011)

Article Neurosciences

Tuning Out the Noise: Limbic-Auditory Interactions in Tinnitus

Josef P. Rauschecker et al.

NEURON (2010)

Article Multidisciplinary Sciences

Auditory discrimination learning and knowledge transfer in mice depends on task difficulty

Simone Kurt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Neurosciences

Change detection by thalamic reticular neurons

Xiong-Jie Yu et al.

NATURE NEUROSCIENCE (2009)

Article Neurosciences

Tonotopic control of auditory thalamus frequency tuning by reticular thalamic neurons

Nathalie Cotillon-Williams et al.

JOURNAL OF NEUROPHYSIOLOGY (2008)

Article Neurosciences

E/I balance and GABAA receptor plasticity

Jean-Marc Fritschy

Frontiers in Molecular Neuroscience (2008)

Article Multidisciplinary Sciences

Corticothalarnic synchronization beads to c-fos expression in the auditory tUarnus

Yi Ping Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Neurosciences

Evidence for synaptic stripping by cortical microglia

Bruce D. Trapp et al.