Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 97, Pages 17277-17280Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05977a
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Funding
- National Natural Science Foundation of China [21372122, 21421062]
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A mild and efficient Rh(III)-catalyzed regioselective synthesis of isoquinolones and pyridones has been developed. The protocol uses readily available N-methoxybenzamide or N-methoxymethacryl-amide and diazo compounds as starting materials. The process involving tandem C-H activation, cyclization, and condensation steps proceeds under mild conditions, and the corresponding isoquinolone and pyridone derivatives were obtained in good to excellent yields with excellent regioselectivities. The process provides a facile approach for the construction of isoquinolone and pyridone derivatives containing various functional groups.
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