4.7 Article

Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 59, Pages 11852-11855

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04357c

Keywords

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Funding

  1. 973 project [2013CB733700]
  2. National Science Fund for Distinguished Young Scholars [81125023]
  3. National Natural Science Foundation of China [21202045, 91213303]
  4. Program of Shanghai Subject Chief Scientist [13XD1404300]
  5. Key Project of Shanghai Science and Technology Commission [13NM1400900]
  6. Fundamental Research Funds for Central Universities [222201414010]

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With this research we demonstrate that glycosylation of a naphthalimide zinc ion probe, using click chemistry, leads to an improvement of the aqueous sensitivity, working pH range and targeting ability for specific cells, together with significantly reduced cytotoxicity.

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