4.4 Article

Cerebrospinal fluid-administered therapies for leptomeningeal metastases from solid tumors

Related references

Note: Only part of the references are listed.
Article Oncology

A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics

Priya U. Kumthekar et al.

Summary: This study aimed to determine the maximum-tolerated dose of intrathecal trastuzumab and its efficacy in patients with HER2-positive leptomeningeal disease. The study showed that intrathecal trastuzumab was well-tolerated and effective, and did not accumulate in toxic concentrations in the cerebrospinal fluid. It suggests potential improved outcomes for HER2-positive leptomeningeal disease patients.

NEURO-ONCOLOGY (2023)

Review Oncology

Leptomeningeal metastases: the future is now

Rimas V. Lukas et al.

Summary: This article reviews the current diagnostic and therapeutic management of Leptomeningeal metastases (LM) from solid tumors. Different therapeutic modalities are discussed, and future directions for research, particularly the role of cerebrospinal fluid circulating tumor cells and cell free circulating tumor DNA in diagnosis and response assessment, are highlighted.

JOURNAL OF NEURO-ONCOLOGY (2022)

Article Oncology

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis

Jonathan T. Yang et al.

Summary: Compared with photon IFRT, proton craniospinal irradiation (pCSI) improved CNS progression-free survival (PFS) and overall survival (OS) for patients with non-small-cell lung cancer and breast cancer with leptomeningeal metastasis (LM), with no increase in serious treatment-related adverse events (TAEs).

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Osimertinib combined with bevacizumab for leptomeningeal metastasis from EGFR-mutation non-small cell lung cancer: A phase II single-arm prospective clinical trial

Zhi-qin Lu et al.

Summary: The study revealed that osimertinib combined with bevacizumab is an effective treatment option for patients with LM from EGFRm NSCLC, showing good LM progression-free survival and objective response rate.

THORACIC CANCER (2021)

Article Multidisciplinary Sciences

Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis

Priscilla K. Brastianos et al.

Summary: A single-arm Phase II study of 18 patients with leptomeningeal disease (LMD) receiving combined ipilimumab and nivolumab showed promising activity with acceptable safety profile. Larger multicenter clinical trials are needed to validate these results for the rare complication with a very poor prognosis.

NATURE COMMUNICATIONS (2021)

Article Oncology

Efficacy and Safety of Intrathecal Pemetrexed Combined With Dexamethasone for Treating Tyrosine Kinase Inhibitor-Failed Leptomeningeal Metastases From EGFR-Mutant NSCLC-a Prospective, Open-Label, Single-Arm Phase 1/2 Clinical Trial (Unique Identifier: ChiCTR1800016615)

Chengjuan Fan et al.

Summary: The study identified 50 mg pemetrexed as the recommended dose for treating EGFR-mutant non-small cell lung cancer leptomeningeal metastases, resulting in few adverse events and a good treatment response rate. IP was shown to be an effective treatment for patients who had failed tyrosine kinase inhibitors.

JOURNAL OF THORACIC ONCOLOGY (2021)

Review Clinical Neurology

Leptomeningeal metastasis from solid tumors

Jigisha P. Thakkar et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis

Priscilla K. Brastianos et al.

NATURE MEDICINE (2020)

Review Anesthesiology

Complications associated with intrathecal drug delivery systems

E. M. Delhaas et al.

BJA EDUCATION (2020)

Article Oncology

Ventriculolumbar Perfusion Chemotherapy for the Treatment of Leptomeningeal Carcinomatosis A Phase I Study With Pharmacokinetic Data

Ho-Shin Gwak et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2013)

Article Oncology

Survival of breast cancer patients with meningeal carcinomatosis

H. Gauthier et al.

ANNALS OF ONCOLOGY (2010)

Article Oncology

Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis

Ronald J. Bernardi et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2008)

Article Oncology

Breast cancer leptomeningeal metastasis - the role of multimodality treatment

Halina Rudnicka et al.

JOURNAL OF NEURO-ONCOLOGY (2007)

Article Oncology

Intrathecal mafosfamide: A preclinical pharmacology and phase I trial

SM Blaney et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Article Oncology

Phase I clinical trial of intrathecal topotecan in patients with neoplastic meningitis

SM Blaney et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

Article Oncology

Intracavitary chemotherapy with 5-fluoro-2′-deoxyuridine (FdUrd) in malignant brain tumors

H Nakagawa et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2001)