Synthesis of hydrazinylthiazole carboxylates: a mechanistic approach for treatment of diabetes and its complications

Aim: The deaths of thousands of people and millions affected by diabetes mellitus triggered us to look for alternative possible solutions to cure diabetes and its complications. Materials & methods: A series of hydrazinylthiazole carboxylates (3a-n) was prepared by cyclocondensation reaction of thiosemicarbazones with ethyl 2-chloroacetoacetate. These compounds were screened for antidiabetic potential through a-amylase inhibition, antiglycation and antioxidant assays. Results & conclusion: Most of the compounds exhibited a promising antidiabetic property. Compounds 3e and 3h showed excellent a-amylase and glycation inhibition properties. The hemolytic assay indicated that all compounds are biocompatible. Docking studies carried out on a-amylase target showed correlation between in vitro inhibition and binding energy.

Automated summary

In search of alternative solutions to diabetes and its complications, this study examined the antidiabetic potential of hydrazinylthiazole carboxylates. Compounds 3e and 3h showed excellent antidiabetic properties, with significant inhibition of a-amylase and glycation.