Journal
FUTURE MEDICINAL CHEMISTRY
Volume 15, Issue 17, Pages 1603-1619Publisher
Newlands Press Ltd
DOI: 10.4155/fmc-2023-0173
Keywords
1,3,4-thiadiazole; apoptosis; breast cancer; caspase 3/7; hormone sensitive; hybridization; (S)-verbenone; triple negative
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This study aims to develop novel isoxazoline-1,3,4-thiadiazole hybrids from (S)-verbenone and investigates their potential anticancer effects. The compound 8b exhibited remarkable cytotoxicity and apoptosis-inducing activity against MCF-7 and MDA-MB-231 breast cancer cells.
Background: This study aimed to develop novel isoxazoline-1,3,4-thiadiazole hybrids from (S)-verbenone for potential anticancer treatment, particularly focusing on cytotoxic and apoptotic effects in hormone-sensitive MCF-7 and triple-negative MDA-MB-231 breast cancer cells. Methods & results: (S)-verbenone was used to synthesize hybrids through 1,3-dipolar cycloaddition, followed by thorough characterization. The compounds were screened across cancer cell lines, showing significant anticancer effects. Compound 8b notably induced apoptosis via the caspase-3/7 pathway and cell cycle arrest, displaying noteworthy cytotoxicity against MCF-7 and MDA-MB-231 cells. Conclusion: These findings underscore the potential of (S)-verbenone isoxazoline-1,3,4-thiadiazole derivatives for breast cancer therapy due to their remarkable apoptotic activity. This study highlights a promising avenue for advancing breast cancer treatment using these derivatives, founded on (S)-verbenone, showcasing their distinct potential for inducing apoptosis. [GRAPHICS] .
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