4.3 Review

Deliberation on debilitating condition of cancer cachexia: Skeletal muscle wasting

Related references

Note: Only part of the references are listed.
Review Oncology

Unveiling the Role of the Proton Gateway, Uncoupling Proteins (UCPs), in Cancer Cachexia

Mit Joshi et al.

Summary: Cancer cachexia is a wasting syndrome driven by chronic inflammation and high energy expenditure. Uncoupling proteins (UCPs) play an important role in cancer cachexia by increasing the body's overall energy utilization. This review provides new insights into the role of UCPs in cancer cachexia and highlights their potential as a target for treating this syndrome.

CANCERS (2023)

Review Oncology

Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia

Bahar Zehra Camurdanoglu Weber et al.

Summary: Cancer cachexia is a disorder characterized by wasting of adipose tissue and skeletal muscle, leading to severe weight loss. There is a limited range of treatment options available for this condition. Changes in metabolic pathways in adipose tissue are associated with cancer cachexia. The energy-wasting circuits in adipose tissue impact whole-body metabolism, particularly skeletal muscle. Targeting key molecular players involved in metabolic reprogramming may help in developing new treatment strategies for cancer cachexia.

FRONTIERS IN ONCOLOGY (2022)

Review Biology

The Role of Autophagy Modulated by Exercise in Cancer Cachexia

Julia Windi Gunadi et al.

Summary: Exercise has the potential to be used in treating cancer cachexia by modulating autophagy. The type of exercise may influence autophagy modulation, with combined or aerobic exercise showing more benefits in cancer cachexia compared to resistance exercise alone. Further research is needed to determine the physiological role of autophagy modulated by exercise and optimize the levels for preserving muscle function and regulating energy utilization in the liver.

LIFE-BASEL (2021)

Article Oncology

Impact of TNF-α Gene Polymorphisms on Pancreatic and Non-Small Cell Lung Cancer-Induced Cachexia in Adult Egyptian Patients: A Focus on Pathogenic Trajectories

Rana Yehia et al.

Summary: In both pancreatic and NSCL cancer patients, TNF-alpha gene mutations are associated with cachexia. High levels of miR-155 are positively correlated with cachexia severity. SOCS1 and Foxp3 levels are significantly lower in cachectic patients compared to non-cachectic patients.

FRONTIERS IN ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Distinct glycolytic pathway regulation in liver, tumour and skeletal muscle of mice with cancer cachexia

Nishant P. Visavadiya et al.

Summary: The study suggests that in cancer cachexia, there are several substrate shuttles among liver, skeletal muscle, and tumor, contributing to metabolic disruption and weight loss. Therapies aimed at normalizing dysregulated substrate shuttling among energy-regulating tissues could potentially alleviate unintended weight loss in cancer cachexia.

CELL BIOCHEMISTRY AND FUNCTION (2021)

Review Biochemistry & Molecular Biology

IGF-1 and IGFBP-3 in Inflammatory Cachexia

Ana Isabel Martin et al.

Summary: Inflammation triggers a broad response from the neuroendocrine system, affecting all the endocrine axes, particularly the hypothalamic-growth hormone-insulin-like growth factor-1 axis. While the endocrine and metabolic responses to acute inflammation support organism survival, chronic inflammation contributes to catabolic processes leading to muscle wasting and weakness. The inhibition of the hypothalamic-GH-IGF-1 axis plays a role in this mechanism.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Evaluation and Validation of the Prognostic Value of Serum Albumin to Globulin Ratio in Patients With Cancer Cachexia: Results From a Large Multicenter Collaboration

Hai-Lun Xie et al.

Summary: The study found that albumin-globulin ratio (AGR) is an independent prognostic factor in patients with cancer cachexia, especially in advanced patients. Compared with other malnutrition evaluation tools, AGR can effectively stratify the prognosis of patients with cancer cachexia.

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Inflammation and Skeletal Muscle Wasting During Cachexia

Justine M. Webster et al.

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Insulin resistance and body composition in cancer patients

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ANNALS OF ONCOLOGY (2018)

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Cancer Cachexia: More Than Skeletal Muscle Wasting

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Hetal J. Patel et al.

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Justin P. Hardee et al.

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PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

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T. G. Anthony

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Protein breakdown in cancer cachexia

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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2016)

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Autophagy is induced in the skeletal muscle of cachectic cancer patients

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SCIENTIFIC REPORTS (2016)

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Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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FEBS JOURNAL (2013)

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PANCREAS (2012)

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Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

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SCIENCE (2011)

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Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

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JOURNAL OF CELL BIOLOGY (2010)

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The role of cytokines in cancer cachexia

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Current Opinion in Supportive and Palliative Care (2009)

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