Flavonoids: a review on biosynthesis and transportation mechanism in plants

In recent years, significant progress has been made in understanding the biosynthetic pathway and regulation of flavonoids through forward genetic approaches. However, there remains a notable gap in knowledge regarding the functional characterization and underlying processes of the transport framework responsible for flavonoid transport. This aspect requires further investigation and clarification to achieve a comprehensive understanding. Presently, there are a total of four proposed transport models associated with flavonoids, namely glutathione S-transferase (GST), multidrug and toxic compound extrusion (MATE), multidrug resistance-associated protein (MRPs), and bilitranslocase-homolog (BTL). Extensive research has been conducted on the proteins and genes related to these transport models. However, despite these efforts, numerous challenges still exist, leaving much to be explored in the future. Gaining a deeper understanding of the mechanisms underlying these transport models holds immense potential for various fields such as metabolic engineering, biotechnological approaches, plant protection, and human health. Therefore, this review aims to provide a comprehensive overview of recent advancements in the understanding of flavonoid transport mechanisms. By doing so, we aim to paint a clear and coherent picture of the dynamic trafficking of flavonoids.

Automated summary

Significant progress has been made in understanding the biosynthesis and regulation of flavonoids through genetic approaches, but there is still a gap in knowledge about their transport mechanisms. Currently, four transport models have been proposed, and research has been conducted on the proteins and genes associated with these models. Challenges still exist, but gaining a deeper understanding of these transport mechanisms holds great potential for various fields. This review aims to provide an overview of recent advancements in flavonoid transport mechanisms.