4.4 Article

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

Journal

METALLOMICS
Volume 8, Issue 2, Pages 156-160

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5mt00288e

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Funding

  1. Australian Research Council [DP130100357]
  2. UTS Chancellor's Postdoctoral Fellowship
  3. US National Institutes of Health - Office of Research Infrastructure Programs [P40 OD010440]
  4. Victorian Government

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Here, we present a sub-mu m multimodal approach to image essential elements in Caenorhabditis elegans. A combination of chemical imaging technologies reveals total metal concentration, chemical state and the protein to which an element is associated. This application of distinct yet complementary chemical imaging techniques provided unique insight into essential and trace elements at the subcellular level.

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