Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 12, Pages 2301-2303Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09256b
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Funding
- NSF SBIR Phase I grant [IIP-1215462]
- Wake Forest University Health Sciences
- Department of Energy Office of Science, Nuclear Physics Isotope Program [DESC0008657]
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1353612] Funding Source: National Science Foundation
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The development of bifunctional chelators (BFCs) which can stably chelate zirconium-89 (Zr-89) while being conjugated to targeting molecules is an area of active research. Herein we report the first octadentate terephthalamide ligands, which are easily radiolabeled with Zr-89 and are highly stable in vitro. They represent a novel class of chelators, which are worthy of further development as BFCs for Zr-89.
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