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Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling
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ENVIRONMENTAL SCIENCE & TECHNOLOGY (2015)
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Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine:An Intracerebral Microdialysis Study in Conscious Rats
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PHARMACEUTICAL RESEARCH (2015)
Pregnane X Receptor Knockout Mice Display Aging-Dependent Wearing of Articular Cartilage
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CURRENT DIABETES REPORTS (2014)
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DRUG DISCOVERY TODAY (2014)
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Extraction agents for the removal of polycyclic aromatic hydrocarbons (PAHs) from soil in soil washing technologies
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GERIATRICS & GERONTOLOGY INTERNATIONAL (2014)
Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4
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IMMUNITY (2014)
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REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2014)
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Frederic D. L. Leusch et al.
WATER RESEARCH (2014)
Effect-directed analysis of endocrine-disrupting compounds in multi-contaminated sediment: identification of novel ligands of estrogen and pregnane X receptors
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013)
Pregnane X Receptor Agonists Impair Postprandial Glucose Tolerance
J. Rysa et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily
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CURRENT DRUG METABOLISM (2013)
PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice
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DIABETES (2013)
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DRUG DISCOVERY TODAY (2013)
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ENVIRONMENTAL POLLUTION (2013)
Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα
Bret D. Wallace et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Effects of nuclear receptor transactivation on steroid hormone synthesis and gene expression in porcine Leydig cells
Matthew A. Gray et al.
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Overview on polycyclic aromatic hydrocarbons: Occurrence, legislation and innovative determination in foods
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TALANTA (2013)
Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes
Maike Gaehrs et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors
Katie B. Paul et al.
TOXICOLOGY IN VITRO (2013)
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR
Claudia Luckert et al.
TOXICOLOGY LETTERS (2013)
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
Alfred H. Schinkel et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters
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BIOCHEMICAL PHARMACOLOGY (2012)
Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules
Hans Matter et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor
Takeshi Kumagai et al.
DRUG METABOLISM AND PHARMACOKINETICS (2012)
ENDOCRINE DISRUPTORS IN THE ENVIRONMENT AND THEIR IMPACT ON HUMAN HEALTH
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ENVIRONMENTAL ENGINEERING AND MANAGEMENT JOURNAL (2012)
Bisphenol A and Its Analogues Activate Human Pregnane X Receptor
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ENVIRONMENTAL HEALTH PERSPECTIVES (2012)
Effect directed analysis and mixture effects of estrogenic compounds in a sediment of the river Elbe
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2012)
Role of CAR and PXR in xenobiotic sensing and metabolism
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EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Genome-Wide Enrichment Screening Reveals Multiple Targets and Resistance Genes for Triclosan in Escherichia coli
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Immunomodulatory effects of environmental endocrine disrupting chemicals
Chang-Hung Kuo et al.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES (2012)
Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways
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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)
Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters
Safaa Yehia Eid et al.
PHYTOMEDICINE (2012)
GPR30, the Non-Classical Membrane G Protein Related Estrogen Receptor, Is Overexpressed in Human Seminoma and Promotes Seminoma Cell Proliferation
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Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes
Vanessa Delfosse et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
QSAR prediction of antagonistic activity of PCBs towards human PXR by using heuristic method and best subset modeling
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SCIENCE CHINA-CHEMISTRY (2012)
Pregnane X receptor as a target for treatment of inflammatory bowel disorders
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TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Endocrine Disruptors: From Endocrine to Metabolic Disruption
Cristina Casals-Casas et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 73 (2011)
Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR
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BIOCHEMICAL PHARMACOLOGY (2011)
Nuclear receptor PXR, transcriptional circuits and metabolic relevance
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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
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CELL (2011)
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice
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JOURNAL OF CLINICAL INVESTIGATION (2011)
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR
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Selective Phthalate Activation of Naturally Occurring Human Constitutive Androstane Receptor Splice Variants and the Pregnane X Receptor
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TOXICOLOGY AND APPLIED PHARMACOLOGY (2011)
Negative impact of endocrine-disrupting compounds on human reproductive health
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2010)
Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss)
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PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line
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Phthalate Esters in Foods: Sources, Occurrence, and Analytical Methods
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COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2010)
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Orphan Nuclear Receptors as Targets for Drug Development
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G protein-coupled receptor 30 in tumor development
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The Structural Basis of Pregnane X Receptor Binding Promiscuity
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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
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Modulation of Phase II Enzymes by Sulforaphane: Implications for Its Cardioprotective Potential
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)
Exposure to endocrine disrupting compounds via the food chain: Is packaging a relevant source?
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SCIENCE OF THE TOTAL ENVIRONMENT (2009)
Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR)
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PXR and CAR in energy metabolism
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Role of vitamin D receptor in the lithocholic acid- mediated CYP3A induction in vitro and in vivo
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EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Effects of endocrine disruptors on obesity
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Xenoreceptors CAR and PXR activation and consequences on lipid metabolism, glucose homeostasis, and inflammatory response
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Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions
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被撤回的出版物: Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene (Retracted article. See vol. 34, pg. 918, 2014)
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Human pregnane x receptor and resistance to chemotherapy in prostate cancer
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Human exposure to bisphenol A (BPA)
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The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators
Erik K. Pacyniak et al.
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Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine
Kevin M. Crofton et al.
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CAR and PXR: The xenobiotic-sensing receptors
Yoav E. Timsit et al.
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Yonggong Zhai et al.
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Pregnane X receptor and natural products: beyond drug-drug interactions
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EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)
International Union of Pharmacology.: LXII.: The NR1H and NR1I receptors:: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor
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Liver disease selectively modulates cytochrome P450-mediated metabolism
Reginald F. Frye et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development
Robert G. Ellis-Hutchings et al.
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Cedric Duret et al.
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Triclosan and antimicrobial resistance in bacteria: An overview
Siamak P. Yazdankhah et al.
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Geraldine Lemaire et al.
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A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
Jie Zhou et al.
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Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4α and coactivators, and suppression of small heterodimer partner gene expression
TG Li et al.
DRUG METABOLISM AND DISPOSITION (2006)
In vitro and in vivo assessment of herb drug interactions
R Venkataramanan et al.
LIFE SCIENCES (2006)
Human exposure to phthalates via consumer products
T Schettler
INTERNATIONAL JOURNAL OF ANDROLOGY (2006)
The nuclear xenobiotic receptor pregnane X receptor: Recent insights and new challenges
J Orans et al.
MOLECULAR ENDOCRINOLOGY (2005)
CAR and PXR: Xenosensors of endocrine disrupters?
XC Kretschmer et al.
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Structure and function of the human nuclear xenobiotic receptor PXR
VE Carnahan et al.
CURRENT DRUG METABOLISM (2005)
Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses
ME Wyde et al.
TOXICOLOGICAL SCIENCES (2005)
Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
CJ Marek et al.
BIOCHEMICAL JOURNAL (2005)
The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion
H Masuyama et al.
MOLECULAR ENDOCRINOLOGY (2005)
Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin
JE Chrencik et al.
MOLECULAR ENDOCRINOLOGY (2005)
Xenoestrogens at picomolar to nanomolar concentrations trigger membrane estrogen receptor-α-mediated Ca2+ fluxes and prolactin release in GH3/B6 pituitary tumor cells
AL Wozniak et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2005)
What does an orphan G-protein-coupled receptor have to do with estrogen?
JM Rae et al.
BREAST CANCER RESEARCH (2005)
Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals
DS Riddick et al.
DRUG METABOLISM AND DISPOSITION (2004)
Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR)
MM Tabb et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2004)
Environmental phthalate monoesters activate pregnane X receptor-mediated transcription
CH Hurst et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
S Kodama et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes
XL Song et al.
DRUG METABOLISM AND DISPOSITION (2004)
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
EJ Squires et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17β-estradiol and phytoestrogens in breast cancer cells
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Identification of in vitro estrogen and androgen receptor agonists in North Sea offshore produced water discharges
KV Thomas et al.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2004)
Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR
MM Tabb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The nuclear pregnane X receptor regulates xenobiotic detoxification
SA Kliewer
JOURNAL OF NUTRITION (2003)
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2003)
Nuclear receptors and the control of metabolism
GA Francis et al.
ANNUAL REVIEW OF PHYSIOLOGY (2003)
Pharmacokinetic interactions with rifampicin - Clinical relevance
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CLINICAL PHARMACOKINETICS (2003)
Potential drug targets and progress towards pharmacologic inhibition of hepatic glucose production
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CURRENT MEDICINAL CHEMISTRY (2003)
Environmental endocrine disrupters and disorders of sexual differentiation
J Toppari
SEMINARS IN REPRODUCTIVE MEDICINE (2002)
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
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CELL (2002)
An overview of brominated flame retardants in the environment
CA de Wit
CHEMOSPHERE (2002)
On-line solid-phase extraction and fluorescence detection of selected endocrine disrupting chemicals in water by high-performance liquid chromatography
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JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES (2002)
Nuclear receptors and lipid physiology: Opening the X-files
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SCIENCE (2001)
Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription
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EUROPEAN JOURNAL OF ENDOCRINOLOGY (2001)
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The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
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SCIENCE (2001)
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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
JL Staudinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Thyroid hormones and their effects: a new perspective
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BIOLOGICAL REVIEWS (2000)
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
LB Moore et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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