Central nervous system activity of a Tabernaemontana arborea alkaloid extract involves serotonergic and opioidergic neurotransmission in murine models

Article Plant Sciences

Five centuries of Cirsium ehrenbergii Sch. Bip. (Asteraceae) in Mexico, from Huitzquilitl to Cardo Santo: History, ethnomedicine, pharmacology and chemistry

Silvia Laura Guzman-Gutierrez et al.

Summary: This study investigates the historical and contemporary ethnopharmacological knowledge of the endemic herb Cirsum ehrenbergii in Mexico. The results show its potential as an antidepressant and anti-inflammatory agent, validating its traditional use in folk medicine.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Plant Sciences

Antimycobacterial Activity of Alkaloids and Extracts from Tabernaemontana alba and T. arborea

Silvia Laura Guzman-Gutierrez et al.

Summary: Tuberculosis is the leading cause of death from a single infectious agent and drug-resistant strains continue to emerge. The development of new antituberculosis medicines is crucial. Plant-derived alkaloids from Mexican Apocynaceae species have shown promising activity against Mycobacterium tuberculosis, but also exhibited cytotoxicity to mammalian cells. Voacamine, a dimeric bis-indole-type alkaloid, was identified as a potent compound against M. tuberculosis with a low selectivity index.

PLANTA MEDICA (2022)

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Article Neurosciences

Tabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: Involvement of serotonin 5-HT1A receptors

Maria Eva Gonzalez-Trujano et al.

Summary: This study evaluated the effect of Tabernaemontana arborea extract and its alkaloids on EEG activity in mice. The results showed that high doses of the extract induced abnormal EEG activity, partly due to the presence of ibogaine and involvement of serotonin 5-HT1A receptors. However, other constituents and mechanisms may also contribute to this excitatory activity, which should be explored in future studies.

NEUROTOXICOLOGY (2022)

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Article Plant Sciences

Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice

M. E. Gonzalez-Trujano et al.

Summary: The AcOEt fraction of R. chalepensis was found to be more effective than the aqueous extract in reducing tonic-clonic seizures and mortality in both PTZ and MES tests. The anticonvulsant effect of R. chalepensis does not appear to be mediated by GABA(A) receptors. However, caution is advised when using high doses of AcOEt as it may lead to neurotoxic effects.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Neurosciences