4.7 Article

A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 31, Pages 6781-6784

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01217a

Keywords

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Funding

  1. National Program on Key Basic Research Project of China (973 Program) [2012CB720603, 2013CB328900]
  2. National Science Foundation of China [21232005, 21321061, J1310008, J1103315]
  3. Specialized Research Fund for the Doctoral Program of Higher Education in China [20120181130006]

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A ratiometric fluorescent probe (RMClO-2) for ClO- based on the conjugate of coumarin-rhodamine was presented, which could sense ClO- with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, RMClO-2 is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO-.

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