Time-lapse imaging: Morphokinetic analysis of in vitro fertilization outcomes

Time-lapse imaging (TLI) allows continuous monitoring of embryo development without disturbing culture conditions by removing embryos from the incubator. The study of embryo kinetics using TLI has given rise to some new markers for embryo selection that are able to document and evaluate embryo morphology and the timing of developmental events through continuous live image tracking. Time-lapse imaging has emerged as a powerful tool for creating predictive models of in vitro fertilization outcomes. Fourty-seven articles were included in the present review to investigate the current situation of TLI in in vitro fertilization laboratories. Morphokinetics of the embryo during its in vitro development have been described using parameters indicative of the different events capable of predicting the ability to reach blastocyst stage, implantation and pregnancy rates, live birth outcome, and embryo ploidy. (Fertil Steril & REG; 2023;120:218-27. & COPY;2023 by American Society for Reproductive Medicine.)

Automated summary

Time-lapse imaging is a non-invasive method that allows continuous monitoring of embryo development. It has provided new markers for embryo selection and can be used to create predictive models of in vitro fertilization outcomes. The review of 47 articles shows that morphokinetics of the embryo during in vitro development can predict the ability to reach blastocyst stage, implantation and pregnancy rates, live birth outcome, and embryo ploidy.