Journal
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 65, Issue 8, Pages 1080-1086Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2015.11.008
Keywords
Steatohepatitis; Liver biopsy; Steatosis; Histology
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Funding
- Intramural Research Program of the National Institutes of Health, National Cancer institute
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Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The term encompasses several patterns of liver injury, including a relatively benign condition of steatosis without hepatocellular injury, nonalcoholic steatohepatitis (NASH), and a pattern of zone 1 steatosis, inflammation and fibrosis mainly observed in prepubertal children. Staging and grading systems have been developed to characterize the histological changes in NAFLD, mainly as a tool for clinical research. The histological features of NAFLD across these different manifestations and the scoring systems used to evaluate disease severity are discussed. Published by Elsevier Inc.
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