Journal
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 65, Issue 9, Pages 1376-1390Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2016.05.018
Keywords
Metabolism; Parkinson's disease; Alzheimer's disease; Huntington's diseases; Multiple sclerosis
Categories
Funding
- Fondazione Italiana Sclerosi Multipla (FISM) [2012/R/11, 2014/R/21]
- Italian Space Agency (ASI) [2014-033-R.O]
- Juvenile Diabetes Research Foundation (JDRF) [1-PNF-2015-115-5-B]
- Ministero della Salute [GR-2010-2315414]
- TRIDEO-AIRC [17447]
- European Foundation for the Study of Diabetes/Juvenile Diabetes Research Foundation (EFSD/JDRF)/Lilly Program
- European Foundation for the Study of Diabetes [JDRF Lilly 2015_4] Funding Source: researchfish
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Along with the increase in life expectancy over the last century, the prevalence of age related disorders, such as neurodegenerative diseases continues to rise. This is the case of Alzheimer's, Parkinson's, Huntington's diseases and Multiple sclerosis, which are chronic disorders characterized by neuronal loss in motor, sensory or cognitive systems. Accumulating evidence has suggested the presence of a strong correlation between metabolic changes and neurodegeneration. Indeed epidemiologic studies have shown strong associations between obesity, metabolic dysfunction, and neurodegeneration, while animal models have provided insights into the complex relationships between these conditions. In this context, hormones such as leptin, ghrelin, insulin and IGF-1 seem to play a key role in the regulation of neuronal damage, toxic insults and several other neurodegenerative processes. This review aims to presenting the most recent evidence supporting the crosstalk linking energy metabolism and neurodegeneration, and will focus on metabolic manipulation as a possible therapeutic tool in the prevention and treatment of neurodegenerative diseases. (C) 2016 Elsevier Inc. All rights reserved.
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