4.5 Review

Proteasome inhibitors as anticancer agents

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer

Qian Zhou et al.

Summary: The study revealed that Carfilzomib effectively converted M2 macrophages into M1-like macrophages, reshaped the tumor microenvironment, and synergized with PD-1 inhibitors to treat autochthonous lung cancers.

EMBO MOLECULAR MEDICINE (2022)

Article Materials Science, Multidisciplinary

Novel fabrication of marizomib-loaded chitosan-coated hydroxyapatite nanocarriers as a promising system for effective treatment of ovarian cancer

Jia Xu et al.

Summary: Nanotechnology has the potential to significantly improve cancer therapy. High-performance hydroxyapatite (HA) nanoparticles, encapsulated with a pH-sensitive biopolymer and chitosan, enhance the efficacy and bioavailability of marizomib in fighting against ovarian cancer cells. The newly fabricated nanoparticles effectively kill cancer cells and induce apoptosis.

MATERIALS RESEARCH EXPRESS (2022)

Review Biochemistry & Molecular Biology

Site-Specific Proteasome Inhibitors

Alexei F. Kisselev

Summary: Proteasome is a crucial protein degradation machine in maintaining protein homeostasis and regulating cell functions. FDA-approved proteasome inhibitors are used for multiple myeloma treatment. Various inhibitors target different active sites of the proteasome, impacting its biological functions and identifying potential drug targets for disease treatment.

BIOMOLECULES (2022)

Review Immunology

Targeting Proteasomes in Cancer and Infectious Disease: A Parallel Strategy to Treat Malignancies and Microbes

James J. Ignatz-Hoover et al.

Summary: Essential core pathways of cellular biology are preserved throughout evolution, and proteins are regulated by the proteasome, a highly intricate and tightly regulated complex. Deregulation of the proteasome has been linked to various diseases, including cancer. Proteasome inhibitors selectively target cancer cells and have the potential to improve treatment of infectious diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Article Oncology

Phase 1b study of carfilzomib with induction chemotherapy in pediatric relapsed/refractory acute lymphoblastic leukemia

Michael J. Burke et al.

Summary: The study aimed to evaluate the safety and tolerability of carfilzomib combined with VXLD therapy in children with relapsed and/or refractory ALL. The results indicated that the use of carfilzomib in pediatric patients with relapsed and/or refractory ALL is supported, despite some adverse events and side effects.

PEDIATRIC BLOOD & CANCER (2022)

Article Oncology

Combined treatment of marizomib and cisplatin modulates cervical cancer growth and invasion and enhances antitumor potential in vitro and in vivo

Ziruizhuo Zhang et al.

Summary: This study found that Mzb, as a proteasome inhibitor, exhibits significant anticancer effects in cervical cancer cells, and can enhance the cytotoxicity and apoptosis induced by CDDP. By regulating the Ang-1/Tie-2 pathway, Mzb inhibits tumor growth in cervical cancer cells. Therefore, Mzb may be a potential effective drug in combination therapy for cervical cancer.

FRONTIERS IN ONCOLOGY (2022)

Article Cell Biology

PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer

Xueyan Wang et al.

Summary: By performing a genome-wide CRISPR-Cas9 library screening, researchers discovered that inhibiting PSMG2 can increase the sensitivity of triple-negative breast cancer cells to the MEK inhibitor AZD6244. The mechanism involves impairing proteasome function through PSMG2 knockdown, which activates autophagy-mediated degradation of PDPK1. This degradation enhances the tumor growth inhibition induced by AZD6244 by interrupting negative feedback signals towards the AKT pathway.

CELL REPORTS MEDICINE (2022)

Review Biochemistry & Molecular Biology

Beyond K48 and K63: non-canonical protein ubiquitination

Michal Tracz et al.

Summary: Protein ubiquitination, initially known for its role in proteolysis, is now recognized as essential for various cellular processes. Different types of ubiquitin linkages, beyond the commonly studied K48- and K63-linked chains, are equally important and are receiving increasing attention in recent research.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

Review Biochemistry & Molecular Biology

Protein degradation control and regulation of bacterial survival and pathogenicity: the role of protein degradation systems in bacteria

Shilei Dong et al.

Summary: Protein degradation systems are essential in maintaining protein homeostasis and quality control in all organisms. The AAA+ ATPase-protease complex is a major protein degradation system found in cells, playing important roles in bacteria.

MOLECULAR BIOLOGY REPORTS (2021)

Article Toxicology

Proteasome inhibitor MG132 induces apoptosis in human osteosarcoma U2OS cells

Han Ki Lee et al.

Summary: MG132, derived from a Chinese medicinal plant, exhibited anti-proliferative effects, induced apoptosis and DNA damage in U2OS cells, suppressed the enzymatic activity of matrix metalloproteinases, cell migration and invasion, activated apoptotic signaling pathways, and downregulated the phosphorylation of Akt and Erk. These findings suggest MG132 has potential anticancer effects in osteosarcoma treatment.

HUMAN & EXPERIMENTAL TOXICOLOGY (2021)

Review Biochemistry & Molecular Biology

Ubiquitin-proteasome system and the role of its inhibitors in cancer therapy

Fatemeh Aliabadi et al.

Summary: Despite the potential of other cells to prevent cancer development, cancer cells can upregulate the ubiquitin-proteasome system (UPS) to degrade tumour suppressor proteins and avoid apoptosis. Understanding UPS inhibitors is crucial in controlling cancer development, with the need to improve inhibitors for more effective cancer therapy.

OPEN BIOLOGY (2021)

Article Oncology

Ubiquitin-proteasome System Is a Promising Target for Killing Cisplatin-resistant Bladder Cancer Cells

Kazuki Okubo et al.

Summary: The study found that UPS was activated in cisplatin-resistant bladder cancer cells, and UPS-targeting drugs were more effective in inducing apoptosis and inhibiting growth in cisplatin-resistant cells. Furthermore, these drugs could induce endoplasmic reticulum stress at lower concentrations in cisplatin-resistant bladder cancer cells.

ANTICANCER RESEARCH (2021)

Article Cell Biology

Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist

Chiara Boccellato et al.

Summary: The study evaluated the efficacy of combination treatment with IZI1551 and marizomib on glioblastoma cells, finding synergistic induction of apoptotic cell death with the combination treatment. Pre-treatment enhanced cell death, and lowering the mitochondrial apoptosis threshold re-established sensitivity in resistant cells.

CELL DEATH & DISEASE (2021)

Article Oncology

Modulation of Tumor Microenvironment to Enhance Radiotherapy Efficacy in Esophageal Squamous Cell Carcinoma by Inhibiting Carbonic Anhydrase IX

Pengqin Xu et al.

Summary: The study demonstrates that inhibition of CAIX using S4 can alter the hypoxic tumor microenvironment in ESCC, increase DNA damage and apoptosis, thereby enhancing the efficacy of radiotherapy.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

Advancing targeted protein degradation for cancer therapy

Brandon Dale et al.

Summary: The development of small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) has enabled the targeting of previously considered undruggable oncoproteins. This review discusses recent advances in the field, with a focus on opportunities and challenges for future development.

NATURE REVIEWS CANCER (2021)

Review Pharmacology & Pharmacy

Proteasome Inhibitor Drugs

Lloyd D. Fricker

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 60 (2020)

Article Pharmacology & Pharmacy

The active second-generation proteasome inhibitor oprozomib reverts the oxaliplatin-induced neuropathy symptoms

Francesca Felicia Caputi et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Prahlad Raninga et al.

THERANOSTICS (2020)

Review Pharmacology & Pharmacy

A Practical Review of Proteasome Pharmacology

Tiffany A. Thibaudeau et al.

PHARMACOLOGICAL REVIEWS (2019)

Review Pharmacology & Pharmacy

Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later

Pawel Robak et al.

DRUGS IN R&D (2019)

Article Biochemistry & Molecular Biology

An oral second-generation proteasome inhibitor oprozomib significantly inhibits lung cancer in a p53 independent manner in vitro

Hongge Zhu et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2019)

Review Oncology

New proteasome inhibitors in the treatment of multiple myeloma

Vania Tietsche de Moraes Hungria et al.

HEMATOLOGY TRANSFUSION AND CELL THERAPY (2019)

Article Pharmacology & Pharmacy

Proteasome Inhibitor Carfilzomib Enhances the Anticancer Effect of Paclitaxel in MDA-MB-231 Breast Cancer Cells

Hatice Terzi et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Review Medical Laboratory Technology

Next-generation proteasome inhibitors for cancer therapy

Ji Eun Park et al.

TRANSLATIONAL RESEARCH (2018)

Article Cell Biology

Oncogenic addiction to high 26S proteasome level

Peter Tsvetkov et al.

CELL DEATH & DISEASE (2018)

Review Biochemistry & Molecular Biology

Structure and Function of the 26S Proteasome

Jared A. M. Bard et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Review Cell Biology

Regulation of proteasome assembly and activity in health and disease

Adrien Rousseau et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Oncology

Regulation of Protein Degradation by Proteasomes in Cancer

Ho Hee Jang

JOURNAL OF CANCER PREVENTION (2018)

Review Oncology

Positioning of proteasome inhibitors in therapy of solid malignancies

Margot S. F. Roeten et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Proteasome Structure and Assembly

Lauren Budenholzer et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Review Oncology

Proteasome inhibitors in cancer therapy

Elisabet E. Manasanch et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Review Oncology

Proteasome expression and activity in cancer and cancer stem cells

Ioannis A. Voutsadakis

TUMOR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Redox regulation of proteasome function

Maria Lefaki et al.

REDOX BIOLOGY (2017)

Article Oncology

Proteasome Inhibitor MG132 Enhances Sensitivity to Cisplatin on Ovarian Carcinoma Cells In Vitro and In Vivo

Na Guo et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2016)

Article Medicine, General & Internal

Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

P. Moreau et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Chemistry, Medicinal

Spotlight on ixazomib: potential in the treatment of multiple myeloma

Barbara Muz et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2016)

Article Oncology

Carfilzomib is an effective anticancer agent in anaplastic thyroid cancer

Amit Mehta et al.

ENDOCRINE-RELATED CANCER (2015)

Review Pharmacology & Pharmacy

Targeted treatments for multiple myeloma: specific role of carfilzomib

Dhivya Sugumar et al.

PHARMACOGENOMICS & PERSONALIZED MEDICINE (2015)

Review Biochemistry & Molecular Biology

Regulation of proteasome activity in health and disease

Marion Schmidt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)

Article Oncology

Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models

Amanda F. Baker et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)

Article Oncology

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

Izabela Mlynarczuk-Bialy et al.

Translational Oncology (2014)

Review Oncology

MG132, a proteasome inhibitor, induces apoptosis in tumor cells

Na Guo et al.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2013)

Review Biochemistry & Molecular Biology

From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes

Kyung Bo Kim et al.

NATURAL PRODUCT REPORTS (2013)

Review Oncology

The resistance mechanisms of proteasome inhibitor bortezomib

Shuqing Lu et al.

BIOMARKER RESEARCH (2013)

Review Biochemistry & Molecular Biology

Covalent and non-covalent reversible proteasome inhibition

Philipp Beck et al.

BIOLOGICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

Alexei F. Kisselev et al.

CHEMISTRY & BIOLOGY (2012)

Editorial Material Cell Biology

Development of proteasome inhibitors as research tools and cancer drugs

Alfred L. Goldberg

JOURNAL OF CELL BIOLOGY (2012)

Article Chemistry, Multidisciplinary

Elucidation of the alpha-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition

Melissa Ann Graewert et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Article Hematology

The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan

Eric Sanchez et al.

BRITISH JOURNAL OF HAEMATOLOGY (2010)

Article Gastroenterology & Hepatology

Proteasome Inhibitor MG132 Inhibits Angiogenesis in Pancreatic Cancer by Blocking NF-κB Activity

Yoichi Matsuo et al.

DIGESTIVE DISEASES AND SCIENCES (2010)

Article Hematology

BSc2118 is a novel proteasome inhibitor with activity against multiple myeloma

Jan Sterz et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2010)

Article Biochemistry & Molecular Biology

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases

Julius Rabl et al.

MOLECULAR CELL (2008)

Article Respiratory System

The Proteasome Inhibitor MG132 Sensitizes Lung Cancer Cells to TRAIL-induced Apoptosis by Inhibiting NF-k B Activation

Pil Won Seo et al.

TUBERCULOSIS AND RESPIRATORY DISEASES (2008)

Article Biochemistry & Molecular Biology

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

A. L. Goldberg

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Review Chemistry, Multidisciplinary

20S proteasome and its inhibitors: Crystallographic knowledge for drug development

Ljudmila Borissenko et al.

CHEMICAL REVIEWS (2007)

Article Biochemistry & Molecular Biology

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

AF Kisselev et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Microbiology

Salinispora arenicola gen. nov., sp nov and Salinispora tropica sp nov., obligate marine actinomycetes belonging to the family Micromonosporaceae

LA Maldonado et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2005)

Article Biochemistry & Molecular Biology

Tripeptide mimetics inhibit the 20 S proteasome by covalent bonding to the active threonines

HA Braun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemistry & Molecular Biology

Proteasome inhibitors: from research tools to drug candidates

AF Kisselev et al.

CHEMISTRY & BIOLOGY (2001)