☆ 4.6 Review

Challenges and opportunities in delivering oral peptides and proteins

EXPERT OPINION ON DRUG DELIVERY (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Preparation, Drug Distribution, and In Vivo Evaluation of the Safety of Protein Corona Liposomes for Liraglutide Delivery

Ruihuan Ding et al.

Summary: The purpose of this study was to develop a promising formulation for oral liraglutide administration. Cationic liposomes (CLs) linked to AT-1002 were prepared using a double-emulsion method, and BSA was adsorbed on the surface of the AT-CLs, resulting in protein corona cationic liposomes with AT-1002 (Pc-AT-CLs). The Pc-AT-CLs had a particle size of 202.9 +/- 12.4 nm, a potential of 1.76 +/- 4.87 mV, and an encapsulation efficiency of 84.63 +/- 5.05%.

NANOMATERIALS (2023)

Add to Collection

Article Chemistry, Multidisciplinary

In Situ Polymerization of Zwitterions on Therapeutic Proteins to Enable Their Effective Oral Delivery

Huapan Fang et al.

Summary: We developed an efficient oral protein delivery strategy by using in situ polymerization of zwitterions to encapsulate proteins, enabling them to pass through intestinal barriers and be released in the intestine. This strategy allowed for effective oral delivery of various proteins, including high molecular weight ones, such as antibodies. The oral bioavailabilities of insulin and immunoglobin G (IgG) were significantly improved using this strategy, with no observed toxic effects.

ACS NANO (2023)

Add to Collection

Review Pharmacology & Pharmacy

Bacteria and bacterial derivatives as delivery carriers for immunotherapy

Sae-Ryung Kang et al.

Summary: There is a growing interest in the role of microorganisms in human health and disease, with evidence suggesting that biotherapies using engineered bacteria and their derivatives can address specific disease mechanisms. The complex interactions between microorganisms and metabolic/immunologic pathways are fundamental to many diseases with unmet medical needs, and targeting these interactions may improve patient treatment.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Preparation of Oral Core-Shell Zein Nanoparticles to Improve the Bioavailability of Glycyrrhizic Acid for the Treatment of Ulcerative Colitis

Anxin Wu et al.

Summary: This study developed oral colon-targeted adhesion core-shell nanoparticles using FA-Zein as the core and pectin as the shell to improve the bioavailability of glycyrrhizic acid and enhance its anti-inflammatory effects in specific parts of the intestine. The nanoparticles showed stability in the stomach and small intestine, and released GA in the colon with abundant flora. Targeting with folate-acid was confirmed in cell studies, and the NPs exhibited high adhesion on the colon in a mouse model of ulcerative colitis, reducing levels of MPO and TNF-alpha through decreasing macrophages and neutrophils.

BIOMACROMOLECULES (2022)

Add to Collection

Article Materials Science, Biomaterials

Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody

Tushar Kumeria et al.

Summary: Porous silicon nanoparticles loaded with IgA2 antibodies and coated with pH-responsive polymers were used to achieve controlled release of the drug. The results showed that the formulation released almost no drug in simulated gastric fluid, but released over 50% of the drug in solutions at pH 6.8 or 7.4, with 21-44% of the released drug retaining functional activity. The capsule-based system outperformed the polymer-coated nanoparticles in preserving the activity of the released protein.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

Add to Collection

Article Instruments & Instrumentation

A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects

Arvinder K. Dhalla et al.

Summary: Biotherapeutics are difficult to deliver orally, but our orally ingestible robotic pill (RP) has shown promising safety and reliability in clinical studies, potentially serving as a versatile and reliable oral drug delivery platform.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

Add to Collection

Article Multidisciplinary Sciences

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

Jun-Jie Zou et al.

Summary: Oral protein delivery is a cutting-edge technology that offers superior patient compliance and convenience compared with injections. However, the instability and inefficiency of protein penetration in the gastrointestinal tract have limited the development of oral protein formulation. In this study, acid-resistant metal-organic framework nanoparticles were used to encapsulate insulin and target proteins were added to enhance oral insulin delivery. The nanoparticles achieved high insulin loading and protected insulin from degradation. Through receptor-mediated transcellular pathway, the nanoparticles efficiently transported across the intestinal epithelium and released insulin under physiological conditions, resulting in a significant hypoglycemic effect and high oral bioavailability. This work demonstrates the potential of functional metal-organic framework nanoparticles for oral biomacromolecule delivery.

SCIENCE ADVANCES (2022)

Add to Collection

Review Pharmacology & Pharmacy

Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

Soheil Haddadzadegan et al.

Summary: The oral administration of therapeutic peptides and proteins faces various barriers, which can be overcome by using lipid-based nanocarriers. These nanocarriers enhance the lipophilic character of the drugs and protect them from enzymatic degradation. They can penetrate mucus and absorption membranes, enabling systemic delivery of the therapeutic molecules. Lipid-based nanocarriers show promising stability and delivery efficacy.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection

Article Engineering, Environmental

Biomimetic erythrocytes engineered drug delivery for cancer therapy

Wenyuan Zhang et al.

Summary: Cancer is a leading cause of high mortality, and traditional chemotherapy often leads to adverse reactions that further increase the risk of death. Biomimetic drug delivery systems, using red blood cell membrane camouflage, can extend the half-life of nanoparticles by separating them from the surrounding environment and avoiding recognition by macrophages.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection

Article Pharmacology & Pharmacy

Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice

Ruifeng Mao et al.

Summary: Oral vaccination with bacterium-like particles (BLPs) can induce antigen-specific immune tolerance and reduce the incidence of type 1 diabetes mellitus (T1DM). The stability of the delivered autoantigen is enhanced by BLPs, leading to the preservation of insulin secretion and reduction of insulitis in mice.

DRUG DELIVERY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Progress and limitations of oral peptide delivery as a potentially transformative therapy

Huyen Tran et al.

Summary: This article reviews various technologies for oral peptide delivery, including permeation enhancer technology and emerging strategies such as nanoparticles and gut shuttles. Despite the success of permeation enhancers, low oral bioavailability remains a significant challenge for oral peptide delivery. The development of ingestible devices and ligand-mediated transport may offer new approaches to improve oral bioavailability and transform injectable peptides into oral formulations.

EXPERT OPINION ON DRUG DELIVERY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Smart Hydrogels for Advanced Drug Delivery Systems

Aydin Bordbar-Khiabani et al.

Summary: Smart hydrogels, a type of material that can respond to stimuli and adapt their responses based on external cues, have emerged as a promising research frontier in the field of biomedical engineering. With their high stability, physicochemical properties, and biocompatibility, smart hydrogels have the potential to be used in drug delivery systems. By changing their properties under external stimuli such as pH, temperature, electrical and magnetic fields, light, and biomolecules concentration, smart hydrogels can achieve controlled release of loaded drugs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Gastroenterology & Hepatology

Novel drug delivery systems for inflammatory bowel disease

Farah Yasmin et al.

Summary: Inflammatory bowel disease (IBD) is a chronic illness with complex pathogenesis. The current treatment methods have limitations, so novel drug delivery systems are introduced to overcome these limitations.

WORLD JOURNAL OF GASTROENTEROLOGY (2022)

Add to Collection

Article Cell Biology

Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms

Songhai Tian et al.

Summary: In this study, protein-based delivery systems were developed using detoxified single-chain bacterial toxins as carriers. These systems can deliver large protein cargoes into specific cells in a receptor-dependent manner. Delivery of Cas13a, CasRx, Cas9, and Cre recombinase had different effects on gene expression in various cell lines.

CELL REPORTS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Multi-functional self-assembly nanoparticles originating from small molecule natural product for oral insulin delivery through modulating tight junctions

Xiaohui Jia et al.

Summary: This study developed multi-functional self-assembly nanoparticles as carriers for oral insulin delivery. These nanoparticles exhibited pH stimuli-responsive insulin release, intestinal mucoadhesion, and enhanced absorption. The carrier also improved the paracellular permeability for insulin absorption through downregulation of internal tight junction proteins.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Article Nanoscience & Nanotechnology

Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment

Yuan Yang et al.

Summary: In this study, a two-electrode microneedle patch (t-EMNP) was developed for improving the transdermal drug delivery efficacy in the treatment of atopic dermatitis. The drug loading capability and release rate of the microneedles could be controlled by adjusting the polymerization time, drug concentration, and applied voltage. The patch demonstrated remarkable performance of electricity-triggered drug release, effectively delivering more drugs into the skin and alleviating atopic dermatitis.

ACS APPLIED MATERIALS & INTERFACES (2022)

Add to Collection

Review Polymer Science

Progressive Trends on the Biomedical Applications of Metal Organic Frameworks

Gaurav Awasthi et al.

Summary: Metal-organic frameworks (MOF) technology in biomedical applications faces challenges in selecting metal ions/organic linkers, synthesis techniques, water stability/solubility, toxicity, and biomolecule/drug tagging/conjugation. However, MOF technology offers interesting features such as biological or pharmacological activity, biocompatibility, limited toxicity, specific host-guest interactions, and environmental friendliness.

POLYMERS (2022)

Add to Collection

Review Pharmacology & Pharmacy

The Application and Challenge of Binder Jet 3D Printing Technology in Pharmaceutical Manufacturing

Xuejun Chen et al.

Summary: This paper discusses the application and potential of 3D printing technology in the pharmaceutical field, focusing on the critical process parameters of binder jet 3D printing technology and the unresolved questions.

PHARMACEUTICS (2022)

Add to Collection

Review Chemistry, Medicinal

Gastrointestinal Permeation Enhancers for the Development of Oral Peptide Pharmaceuticals

Jae Cheon Kim et al.

Summary: Recently, two oral-administered peptide pharmaceuticals, semaglutide and octreotide, have been developed and are considered as a breakthrough in peptide and protein drug delivery system development. These two oral peptide products have achieved significant success, but the poor permeability of peptides through the intestinal epithelium remains a major obstacle. Therefore, gastrointestinal permeation enhancers are crucial for the development of oral peptide products.

PHARMACEUTICALS (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

Wei Liu et al.

Summary: In this study, a novel double layer nanoparticles were designed to enhance the oral bioavailability of anticancer drugs. The nanoparticles can act in a temporally controlled manner via an endogenous pathway in the intestine, overcoming multiple limitations of oral delivery. The results showed that the nanoparticles had good stability and prolonged intestinal retention time, as well as enhanced active transportation. Compared to conventional oral drugs, the use of these nanoparticles significantly improved the drug bioavailability and demonstrated better antitumor efficacy and safety.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

Add to Collection

Article Immunology

Orally Administered Brain Protein Combined With Probiotics Increases Treg Differentiation to Reduce Secondary Inflammatory Damage Following Craniocerebral Trauma

Yang Cui et al.

Summary: Craniocerebral trauma can lead to secondary inflammatory responses, exacerbating brain damage and cognitive dysfunction. Administration of brain protein combined with probiotics reduces secondary inflammatory responses and promotes T-cell differentiation into regulatory T cells.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Pharmacology & Pharmacy

Glucose-Modified Zein Nanoparticles Enhance Oral Delivery of Docetaxel

Yabing Xing et al.

Summary: Structuring nanoparticles with glucose as a target is an effective strategy to enhance oral bioavailability and anti-tumor effects of drugs. In this study, a novel drug delivery system using glucose-modified zein nanoparticles loaded with docetaxel was prepared and characterized. The results showed that the glucose modification significantly enhanced cellular uptake and absorption of the nanoparticles, prolonged the drug's residence time in the body, and increased its oral bioavailability. The modified nanoparticles also reduced drug distribution in certain organs and increased tumor distribution and growth inhibition rate without causing systemic toxicity. These findings demonstrate the potential of glucose-modified zein nanoparticles as nanocarriers for enhancing the efficacy of oral drugs and their anti-tumor effects.

PHARMACEUTICS (2022)

Add to Collection

Article Nanoscience & Nanotechnology

Oral Administration of Therapeutic Enzyme Capsule for the Management of Inflammatory Bowel Disease

Xiao Liang et al.

Summary: In this study, antioxidant enzymes were encapsulated in polymeric shells using in situ polymerization. The enzyme capsules demonstrated effective scavenging of ROS and inhibition of pro-inflammatory cytokine secretion, showing great potential in the treatment of inflammatory bowel disease.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

Add to Collection

Review Pharmacology & Pharmacy

Commensal gut microbiota-based strategies for oral delivery of therapeutic proteins

Connie W. Woo et al.

Summary: This opinion article discusses how gut bacteria survive in the harsh environment and explores how their components penetrate the body from the perspective of the bacteria and the host's proactivity. It also discusses the potential development of orally administered therapeutic proteins that utilize similar mechanisms to enter the body.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Add to Collection

Article Mathematical & Computational Biology

The Intervention of Data Mining in the Allocation Efficiency of Multiple Intelligent Devices in Intelligent Pharmacy

Xiaohua Li et al.

Summary: This paper proposes the use of data mining technology to design and develop the dispensing process and equipment of intelligent pharmacy, improving the efficiency of medication dispensing and ensuring the safety and effectiveness of clinical drug use. This study provides support for the intelligent management of modern hospitals.

COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE (2022)

Add to Collection

Review Engineering, Biomedical

Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

Yan Li et al.

Summary: Peptide drugs are important in diabetes mellitus treatment, and oral administration is a convenient and highly compliant strategy. However, unfavorable conditions in the gastrointestinal tract limit the oral bioavailability of these drugs. Various nanoparticles have been developed to improve the oral absorption of peptide drugs. This review provides a comprehensive overview of the unfavorable conditions in the gastrointestinal tract and strategies to overcome these challenges, as well as discussing the application of oral peptide drug nanoparticles in diabetes mellitus treatment.

BIOACTIVE MATERIALS (2022)

Add to Collection

Review Chemistry, Medicinal

Recent Advances in Oral Peptide or Protein-Based Drug Liposomes

Jian Cui et al.

Summary: Liposomes, as a drug delivery system, play an important role in the oral administration of therapeutic peptides. Improvements in the composition and surface properties of liposomes can enhance their stability in the gastrointestinal tract, thereby improving their oral bioavailability.

PHARMACEUTICALS (2022)

Add to Collection

Article Chemistry, Medicinal

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors

Rongjun He et al.

Summary: Protein tyrosine phosphatases are important drug targets, but the lack of drug-like small-molecule inhibitors has limited their potential. Researchers have developed highly effective and selective inhibitors through structure-based design and optimization, with favorable drug-like properties for further study and therapeutic development targeting LMW-PTP.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics

Jacob William Coffey et al.

Summary: Oral vaccination allows for pain-free and self-administered vaccine delivery, inducing both systemic and mucosal immune responses to protect against infection and minimize disease spread. Various challenges in the gastrointestinal tract are being addressed to improve oral vaccine targeting and delivery, with focus on recent advances in oral biologic delivery for future vaccine administration platforms.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

Add to Collection

Review Instruments & Instrumentation

Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques

Marwa Hasanein Asfour

Summary: Proteins and peptides have great potential as therapeutic agents with higher efficiency and lower toxicity, but face challenges in oral bioavailability and transdermal delivery. Recent advancements in drug delivery systems include aquasomes and microneedles, which aim to enhance stability and efficacy of protein and peptide drugs.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Add to Collection

Review Pharmacology & Pharmacy

Oral drug delivery with nanoparticles into the gastrointestinal mucosa

Jiao Liu et al.

Summary: The research progress on the oral route of protein and peptide drugs indicates that nanoparticle drug carriers can overcome the gastrointestinal mucosal barrier, significantly improving bioavailability, but the characteristics of nanoparticles are related to permeability. Nanoparticles can protect drugs from degradation, achieving more effective and sustained drug delivery.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2021)

Add to Collection

Article Pharmacology & Pharmacy

Discovery of novel diarylamides as orally active diuretics targeting urea transporters

Shun Zhang et al.

Summary: A novel UT inhibitor was discovered in this study, showing excellent in vitro UT inhibitory activity and potential for treating hyponatremia accompanied with volume expansion without causing apparent toxicity or electrolyte imbalance.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection

Article Gastroenterology & Hepatology

Novel Orally Administered Recombinant Anti-TNF Alpha Fusion Protein for the Treatment of Ulcerative Colitis Results From a Phase 2a Clinical Trial

Einat Almon et al.

Summary: Oral administration of OPRX-106 was found to be safe and effective in patients with ulcerative colitis, inducing favorable anti-inflammatory immune modulation without immune suppression. Clinical response or remission was observed in the majority of patients, accompanied by improvements in histopathology and immune parameters.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome

Yonghyun Lee et al.

Summary: The gastrointestinal tract plays a crucial role in both local and systemic diseases, influenced by factors like the mucosal immune system, intestinal barrier, and gut microbiota. Selective drug delivery for oral vaccines, immune tolerance, and inflammatory diseases faces challenges due to the physiological and biological barriers of the GIT. Advances in oral nanomedicine offer potential solutions for overcoming these barriers and effectively targeting treatments to the GIT.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Review Pharmacology & Pharmacy

New perspectives in oral peptide delivery

Alessandra T. Zizzari et al.

Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.

DRUG DISCOVERY TODAY (2021)

Add to Collection

Article Oncology

Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers

David S. Weinberg et al.

Summary: Studies suggest that oral GUCY2C agonist could be an effective chemoprevention agent for colorectal cancer, but the investigational oral uroguanylin analog dolcanatide did not activate GUCY2C in epithelial cells of the distal rectum in healthy volunteers, indicating its enhanced stability and extended persistence may not be sufficient to regulate GUCY2C across the colorectum for tumor prevention.

CANCER BIOLOGY & THERAPY (2021)

Add to Collection

Article Chemistry, Applied

Cellulose nanocrystals as support nanomaterials for dual droplet-based freeform 3D printing

Hyung Sun Yoon et al.

Summary: The research developed a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials, offering enhanced printability with improved shape fidelity and structural stability.

CARBOHYDRATE POLYMERS (2021)

Add to Collection

Article Chemistry, Physical

Multidomain drug delivery systems of β-casein micelles for the local oral co-administration of antiretroviral combinations

Prakram Singh Chauhan et al.

Summary: The use of antiretroviral (ARV) cocktail therapy has revolutionized the treatment of HIV and shows promise for other infectious diseases. This study demonstrates a new encapsulation technology platform for oral delivery of fixed dose combinations, enhancing their physicochemical stability and release profiles.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

Add to Collection

Article Materials Science, Biomaterials

Dual pH-responsive-charge-reversal micelle platform for enhanced anticancer therapy

Jianhong Liao et al.

Summary: A novel nanodrug delivery system based on PDPP block copolymers was developed to enhance in vitro cellular uptake and anticancer efficacy. The charge-reversal of micelles from negative to positive at pH 6.5 significantly enhanced cellular uptake and anticancer efficacy.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection

Article Cell Biology

Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

Patrick M. McNutt et al.

Summary: Research has shown that using atoxic derivatives of botulinum neurotoxin can effectively deliver function-blocking antibodies to the neuronal cytosol, neutralizing the toxicity of botulinum toxin. This method has been successful in animal experiments and may enable the treatment of other previously inaccessible intracellular targets.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Controlled Drug Delivery Systems: Current Status and Future Directions

Shivakalyani Adepu et al.

Summary: The paper discusses the evolution of drug delivery systems, the limitations of conventional drug delivery, and the details of controlled drug delivery systems, including design considerations, classifications, and recent research findings on nano-drug delivery, targeted drug delivery, and smart drug delivery using intelligent biomaterials. The challenges and future directions in controlled drug delivery are also addressed in the conclusion.

MOLECULES (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms

Elisabetta Muntoni et al.

Summary: The study found limitations in oral administration of insulin, but promising potential for solid oral dosage forms as glucose-lowering agents, especially effective in healthy rats.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2021)

Add to Collection

Review Pharmacology & Pharmacy

Advances in Oral Drug Delivery

Mohammed S. Alqahtani et al.

Summary: Oral route is the most common and preferred way of drug administration, due to its non-invasiveness and convenience. Factors affecting oral drug absorption include solubility, mucosal permeability, and stability in the gastrointestinal tract. Various pharmaceutical technologies like nanocarriers and micelles have been explored to improve oral drug absorption.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Vishnu Raman et al.

Summary: Limited efficiency in crossing cell membranes hampers the targeting of critical cancer pathways. A Salmonella-based system for intracellular delivery of protein drugs was developed, showing successful reduction of tumors in mouse models of liver cancer and lung metastases.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Instruments & Instrumentation

Current approaches in lipid-based nanocarriers for oral drug delivery

Maria Plaza-Oliver et al.

Summary: Lipid-based nanocarriers have advantages like low toxicity and strong biocompatibility, making them ideal carriers for drugs with poor oral bioavailability. However, efficient oral drug delivery through these carriers is challenging due to multiple physicochemical barriers along the gastrointestinal tract. Rational design of nanocarriers can turn these limitations into opportunities, ultimately determining their future clinical success.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Add to Collection

Article Chemistry, Medicinal

Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

Byung Chull An et al.

Summary: This study evaluated the toxicological effects of a probiotics-based delivery system for p8 protein as an anti-colorectal cancer drug, confirming its efficacy and safety in CRC treatment through animal models and molecular mechanism studies. The non-clinical toxicology studies provided valuable data for the safety certification of PP-P8.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Add to Collection

Review Chemistry, Medicinal

Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability

Saurabh Verma et al.

Summary: Advancements in biotechnology have greatly expanded the application of peptide and protein therapeutics for treating diseases, but their limited bioavailability and stability restricts their usage to parenteral administration. Research is currently focused on overcoming the barriers of oral delivery to improve stability and bioavailability.

DRUG DEVELOPMENT RESEARCH (2021)

Add to Collection

Review Pharmacology & Pharmacy

A Pharmacological and Clinical Overview of Oral Semaglutide for the Treatment of Type 2 Diabetes

Andreas Andersen et al.

Summary: Oral semaglutide is the first GLP-1 receptor agonist available for oral administration, offering effective glycemic control, weight reduction, and a favorable safety profile for patients with type 2 diabetes.

DRUGS (2021)

Add to Collection

Review Immunology

Interaction Between Commensal Bacteria, Immune Response and the Intestinal Barrier in Inflammatory Bowel Disease

Yongyan Chen et al.

Summary: In inflammatory bowel disease (IBD), damage to intestinal cells leads to commensal bacteria becoming pathogenic, triggering immune responses and inflammation. However, the inflammation also contributes to the progression of IBD.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Bacteria-Based Microdevices for the Oral Delivery of Macromolecules

Zhenping Cao et al.

Summary: This review covers the progress and applications of using bacteria to deliver macromolecules through oral ingestion, discussing the engineering strategies and biomedical applications. It emphasizes the advantages and limitations of this approach.

PHARMACEUTICS (2021)

Add to Collection

Article Chemistry, Medicinal

Improving the Gastrointestinal Stability of Linaclotide

Nayara Braga Emidio et al.

Summary: The high susceptibility to proteolytic degradation in the gastrointestinal tract limits the therapeutic application of peptide drugs, such as linaclotide, for gastrointestinal disorders. Improvements in gastrointestinal stability through strategic modifications of linaclotide analogues can significantly enhance their therapeutic efficacy and create potential for the development of the next generation of orally administered peptide drugs for gastrointestinal disorders.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection

Review Medicine, Research & Experimental

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

Alessandra Spada et al.

Summary: Albumin is an attractive carrier in nanomedicine due to its high biocompatibility, ability to interact with various drugs, and active targeting potential. It has a long serum half-life of around 19 days, promoting half-life extension and targeted drug delivery. The article emphasizes the importance of albumin as a drug delivery system and highlights its potential future trends in drug delivery.

MOLECULAR PHARMACEUTICS (2021)

Add to Collection

Article Chemistry, Analytical

Development of a Laser Gas Analyzer for Fast CO2 and H2O Flux Measurements Utilizing Derivative Absorption Spectroscopy at a 100 Hz Data Rate

Mingxing Li et al.

Summary: A laser gas analyzer has been developed to measure gas concentrations at a data rate of 100 Hz, assisting in eddy covariance calculations for gas fluxes in turbulent high wind speed environments. Experimental tests show that the high detection frequency of the laser gas analyzer contributes about 11% more to flux calculations compared to a 20 Hz data rate in environments with wind speeds of around 10 m/s. This indicates that the laser gas analyzer is more suitable for measurements in high wind speed environments.

SENSORS (2021)

Add to Collection

Review Immunology

Role and Mechanism of Gut Microbiota in Human Disease

Yinwei Chen et al.

Summary: The human gut microbiome plays a crucial role in human health, and dysbiosis may lead to various chronic diseases. The mechanisms of its impact on neurodegenerative diseases, cardiovascular diseases, metabolic diseases, and gastrointestinal diseases are extremely complex.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Add to Collection

Review Pharmacology & Pharmacy

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Quangang Zhu et al.

Summary: Oral administration of proteins and peptides has been a big demand in clinical use, and research has focused on developing new technologies to overcome GI barriers, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, and intestinal microdevices. Some new technologies have been under clinical trials or even on the market.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection

Article Nanoscience & Nanotechnology

Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression

Sheng Xu et al.

Summary: The study provides a useful strategy by fabricating a silk sericin hydrogel system delivering recombinant human lactoferrin (SSH-rhLF) to alleviate chemotherapy-caused immune organ damage, successfully overcoming the challenges of lactoferrin resource scarcity and low delivery efficiency.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Review Engineering, Biomedical

The protein corona and its effects on nanoparticle-based drug delivery systems

Hanmei Li et al.

Summary: The formation of a protein corona (PC) on nanoparticles (NPs) in the blood can influence their behavior. Strategies to reduce PC formation or exploit it to enhance NP functions are discussed in this review. Studying protein-NP interactions can provide insights into their clinical activity in health and disease.

ACTA BIOMATERIALIA (2021)

Add to Collection

Review Pharmacology & Pharmacy

Physical methods for enhancing drug absorption from the gastrointestinal tract

Zhi Luo et al.

Summary: Overcoming GI barriers for oral delivery of peptide and protein-based drugs remains a challenge, with limited success from traditional formulation strategies. Recent exploration of physical interaction-based approaches show promise in improving drug absorption, but face challenges in clinical translation.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Add to Collection

Article Gastroenterology & Hepatology

PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis

William J. Sandborn et al.

Summary: The study highlighted that PTG-100 can effectively block the alpha 4 beta 7 integrin, and demonstrated dose-dependent efficacy in mice and healthy volunteers. Despite the phase 2a trial initially not meeting the primary endpoint, a blinded reread of endoscopy videos by a third party indicated clinical efficacy at certain dosage levels.

GASTROENTEROLOGY (2021)

Add to Collection

Article Chemistry, Medicinal

Gut Organoid as a New Platform to Study Alginate and Chitosan Mediated PLGA Nanoparticles for Drug Delivery

Zahra Davoudi et al.

Summary: This study investigated the effects of different surface charges on the delivery of nanoparticles into intestinal organoids, showing that positively charged nanoparticles were more readily transported across the epithelium into the lumen.

MARINE DRUGS (2021)

Add to Collection

Article Endocrinology & Metabolism

Oral octreotide capsules for the treatment of acromegaly: comparison of 2 phase 3 trial results

Artak Labadzhyan et al.

Summary: Results from trials investigating oral octreotide capsules as an alternative treatment for acromegaly showed consistent biochemical response, durability of response, and patient preference for oral treatment, despite differences in trial design.

PITUITARY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

pH-Sensitive Polymer-Based Carriers as a Useful Approach for Oral Delivery of Therapeutic Protein: A Review

Maryam Shamseddini Lori et al.

Summary: There are various proteins and enzymes in the human body, and their dysfunction can result in diseases. The oral administration of proteins faces challenges due to degradation in the gastrointestinal tract and limited permeability. Studies have shown that the use of pH-sensitive polymer-based carriers can enhance the bioavailability of orally administered proteins.

PROTEIN AND PEPTIDE LETTERS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A Fully Integrated Closed-Loop System Based on Mesoporous Microneedles-Iontophoresis for Diabetes Treatment

Xiangling Li et al.

Summary: This study developed a fully integrated wearable closed-loop system based on a mini-invasive microneedle platform for in situ diabetic sensing and treatment, with features such as painless skin penetration, electrical insulin delivery control, and glucose monitoring. It shows great potential in improving the treatment of diabetic patients.

ADVANCED SCIENCE (2021)

Add to Collection

Article Pharmacology & Pharmacy

Intestinal Transcytosis of a Protein Cargo and Nanoparticles Mediated by a Non-Toxic Form of Pseudomonas aeruginosa Exotoxin A

Ruiying Li et al.

Summary: The study demonstrates the capability of ntPE to facilitate the transcytosis of protein cargo as well as biodegradable nanoparticles across the intestinal epithelium for oral delivery of macromolecular therapeutics, under conditions of covalent or non-covalent association.

PHARMACEUTICS (2021)

Add to Collection

Article Pharmacology & Pharmacy

Pharmacokinetics and Pharmacodynamics of Insulin Tregopil in Relation to Premeal Dosing Time, Between Meal Interval, and Meal Composition in Patients With Type 2 Diabetes Mellitus

Anand Khedkar et al.

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2020)

Add to Collection

Article Oncology

An Orally Available Tubulin Inhibitor, VERU-111, Suppresses Triple-Negative Breast Cancer Tumor Growth and Metastasis and Bypasses Taxane Resistance

Shanshan Deng et al.

MOLECULAR CANCER THERAPEUTICS (2020)

Add to Collection

Review Chemistry, Medicinal

Albumin nanoscience: homing nanotechnology enabling targeted drug delivery and therapy

Shrawani Lamichhane et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

Add to Collection

Article Pharmacology & Pharmacy

Impact of gastrointestinal physiology on drug absorption in special populations – An UNGAP review

Cordula Stillhart et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Advances in oral peptide therapeutics

Daniel J. Drucker

NATURE REVIEWS DRUG DISCOVERY (2020)

Add to Collection

Article Nanoscience & Nanotechnology

A Nanocomposite Vehicle Based on Metal-Organic Framework Nanoparticle Incorporated Biodegradable Microspheres for Enhanced Oral Insulin Delivery

Yuhao Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Add to Collection

Review Pharmacology & Pharmacy

Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches

D. J. Brayden et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Add to Collection

Review Endocrinology & Metabolism

Recent Advances in Insulin Therapy

Leah M. Wilson et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2020)

Add to Collection

Article Gastroenterology & Hepatology

Proton Pump Inhibitor-Related Gastric Mucosal Changes

Gwang Ha Kim

Gut and Liver (2020)

Add to Collection

Article Multidisciplinary Sciences

Large-scale genome-wide analysis links lactic acid bacteria from food with the gut microbiome

Edoardo Pasolli et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Engineering, Biomedical

De novo development of proteolytically resistant therapeutic peptides for oral administration

Xu-Dong Kong et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Add to Collection

Article Pharmacology & Pharmacy

Gastro-protective protein-silica nanoparticles formulation for oral drug delivery: In vitro release, cytotoxicity and mitochondrial activity

Estelle Juere et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Sterculia striata gum as a potential oral delivery system for protein drugs

Alessandra A. R. Freitas et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection

Article Multidisciplinary Sciences

Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed therapy against melanoma

Li-Hua Peng et al.

SCIENCE ADVANCES (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems

Yining Xu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection

Article Oncology

Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer

Foyez Mahmud et al.

CANCER LETTERS (2020)

Add to Collection

Review Pediatrics

An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in Adults and Pediatrics

Nirnoy Dan et al.

CHILDREN-BASEL (2020)

Add to Collection

Article Endocrinology & Metabolism

ACTUALITIES IN ENDOCRINE PHARMACOLOGY: ADVANCES IN THE DEVELOPMENT OF ORAL FORMULATIONS FOR CALCITONIN AND SEMAGLUTIDE

A. Hamza et al.

ACTA ENDOCRINOLOGICA-BUCHAREST (2020)

Add to Collection

Review Medicine, Research & Experimental

3D printing promotes the development of drugs

Xiao Zhu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Transport of artificial virus-like nanocarriers through intestinal monolayers via microfold cells

Tianjian Tong et al.

NANOSCALE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Enzymatic and metabolic regulation of lysine succinylation

Annapoorna Sreedhar et al.

GENES & DISEASES (2020)

Add to Collection

Article Multidisciplinary Sciences

Microemulsion-based approach for oral delivery of insulin: formulation design and characterization

Mumuni A. Momoh et al.

HELIYON (2020)

Add to Collection

Review Pharmacology & Pharmacy

Adapting liposomes for oral drug delivery

Haisheng He et al.

ACTA PHARMACEUTICA SINICA B (2019)

Add to Collection

Article Chemistry, Multidisciplinary

DNA-Functionalized Metal-Organic Framework Nanoparticles for Intracellular Delivery of Proteins

Shunzhi Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Add to Collection

Review Pharmacology & Pharmacy

Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Shu-jun Cao et al.

AAPS PHARMSCITECH (2019)

Add to Collection

Editorial Material Pharmacology & Pharmacy

Oral delivery of nanoparticles - let's not forget about the protein corona

Alberto Berardi et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

Add to Collection

Review Pharmacology & Pharmacy

Oral Drug Delivery Technologies-A Decade of Developments

G. Kaur et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

Maria Jose Chiabai et al.

BMC BIOTECHNOLOGY (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

Gut Microbiome and Response to Cardiovascular Drugs

Sony Tuteja et al.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2019)

Add to Collection

Review Engineering, Biomedical

Polymers for cytosolic protein delivery

Jia Lv et al.

BIOMATERIALS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

A luminal unfolding microneedle injector for oral delivery of macromolecules

Alex Abramson et al.

NATURE MEDICINE (2019)

Add to Collection

Article Pharmacology & Pharmacy

Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice

Muye He et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Add to Collection

Review Biotechnology & Applied Microbiology

The art of vector engineering: towards the construction of next-generation genetic tools

Luisa Czamanski Nora et al.

MICROBIAL BIOTECHNOLOGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Not by (Good) Microbes Alone: Towards Immunocommensal Therapies

Chung-Yin Leung et al.

TRENDS IN MICROBIOLOGY (2019)

Add to Collection

Article Engineering, Biomedical

Protein Corona Liposomes Achieve Efficient Oral Insulin Delivery by Overcoming Mucus and Epithelial Barriers

Aohua Wang et al.

ADVANCED HEALTHCARE MATERIALS (2019)

Add to Collection

Article Chemistry, Applied

Self-assembly pH-sensitive chitosan/alginate coated polyelectrolyte complexes for oral delivery of insulin

Tingting Chen et al.

JOURNAL OF MICROENCAPSULATION (2019)

Add to Collection

Review Medicine, Research & Experimental

Bioengineering of Metal-organic Frameworks for Nanomedicine

Yuan Liu et al.

THERANOSTICS (2019)

Add to Collection

Article Pharmacology & Pharmacy

The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation

Chun Y. Wong et al.

JOURNAL OF DRUG TARGETING (2018)

Add to Collection

Article Medicine, General & Internal

Patient-centered assessment on disease burden, quality of life, and treatment satisfaction associated with acromegaly

Shuqian Liu et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2018)

Add to Collection

Article Pharmacology & Pharmacy

Development of poly(hydroxyethyl methacrylate) nanogel for effective oral insulin delivery

Xiaomei Wang et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2018)

Add to Collection

Article Nanoscience & Nanotechnology

Biomimetic Viruslike and Charge Reversible Nanoparticles to Sequentially Overcome Mucus and Epithelial Barriers for Oral Insulin Delivery

Jiawei Wu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Add to Collection

Review Pharmacology & Pharmacy

PEGylation for enhancing nanoparticle diffusion in mucus

Justin T. Huckaby et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

From nature to creation: Going around in circles, the art of peptide cyclization

Rui-Yang Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Add to Collection

Article Biophysics

Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability

Khaled AboulFotouh et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

Add to Collection

Article Pharmacology & Pharmacy

Dipeptide-modified nanoparticles to facilitate oral docetaxel delivery: new insights into PepT1-mediated targeting strategy

Yuqian Du et al.

DRUG DELIVERY (2018)

Add to Collection

Article Chemistry, Medicinal

Thiodipeptides targeting the intestinal oligopeptide transporter as a general approach to improving oral drug delivery

David W. Foley et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Add to Collection

Article Pharmacology & Pharmacy

Surfactants as stabilizers for biopharmaceuticals: An insight into the molecular mechanisms for inhibition of protein aggregation

Andrea Arsiccio et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Eudragit® L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery

Bohui Xu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Add to Collection

Review Nanoscience & Nanotechnology

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends

Muhammad Farhan Sohail et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

Add to Collection

Review Pharmacology & Pharmacy

Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulin

Chun Y. Wong et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Article Pharmacology & Pharmacy

Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion

Luis Antonio D. Silva et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Acid-Resistant Mesoporous Metal-Organic Framework toward Oral Insulin Delivery: Protein Encapsulation, Protection, and Release

Yijing Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes

Phennapha Saokham et al.

MOLECULES (2018)

Add to Collection

Review Pharmacology & Pharmacy

Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery

Angela M. Wagner et al.

ACTA PHARMACEUTICA SINICA B (2018)

Add to Collection

Article Pharmacology & Pharmacy

Succinylated whey protein isolate as a sustained-release excipient of puerarin derivative oral tablets: Preparation, optimization and pharmacokinetics

Rui Zhang et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular Mechanisms of H-pylori-Induced DNA Double-Strand Breaks

Dawit Kidane

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

Muna Ali Abdalla et al.

MOLECULES (2018)

Add to Collection

Review Immunology

Origin, Differentiation, and Function of Intestinal Macrophages

Calum C. Bain et al.

FRONTIERS IN IMMUNOLOGY (2018)

Add to Collection

Review Gastroenterology & Hepatology

The intestinal epithelial barrier: a therapeutic target?

Matthew A. Odenwald et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Add to Collection

Review Pharmacology & Pharmacy

Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics

Vassilis Bourganis et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumin

Line Hagner Nielsen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

Add to Collection

Article Gastroenterology & Hepatology

Helicobacter pylori, gastric cancer and other gastrointestinal malignancies

Marino Venerito et al.

HELICOBACTER (2017)

Add to Collection

Article Pharmacology & Pharmacy

Functionalized PLA-PEG nanoparticles targeting intestinal transporter PepT1 for oral delivery of acyclovir

Betty Gourdon et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Pharmacology & Pharmacy

Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione

Gergely Hetenyi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Rational design of polyarginine nanocapsules intended to help peptides overcoming intestinal barriers

Zhigao Niu et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Add to Collection

Article Chemistry, Medicinal

How Big Is Too Big for Cell Permeability?

Par Matsson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism

Simon Nicolas et al.

MOLECULAR SYSTEMS BIOLOGY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Evaluation of mesoporous silica nanoparticles for oral drug delivery - current status and perspective of MSNs drug carriers

Justyna Florek et al.

NANOSCALE (2017)

Add to Collection

Review Gastroenterology & Hepatology

The intestinal barrier: a fundamental role in health and disease

Maaike Vancamelbeke et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2017)

Add to Collection

Article Materials Science, Biomaterials

Penetration and drug delivery of albumin nanoparticles into pancreatic multicellular tumor spheroids

Hongxu Lu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

Add to Collection

Article Nanoscience & Nanotechnology

Influence of Particle Geometry on Gastrointestinal Transit and Absorption following Oral Administration

Dong Li et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Add to Collection

Article Robotics

Multifunctional biohybrid magnetite microrobots for imaging-guided therapy

Xiaohui Yan et al.

SCIENCE ROBOTICS (2017)

Add to Collection

Review Polymer Science

Polymeric Hydrogels as Technology Platform for Drug Delivery Applications

Alejandro Sosnik et al.

GELS (2017)

Add to Collection

Review Pharmacology & Pharmacy

Challenges in oral peptide delivery: lessons learnt from the clinic and future prospects

Joel Richard

THERAPEUTIC DELIVERY (2017)

Add to Collection

Article Oncology

Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention

David S. Weinberg et al.

CANCER PREVENTION RESEARCH (2017)

Add to Collection

Review Pharmacology & Pharmacy

Current state and challenges in developing oral vaccines

Julia E. Vela Ramirez et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Add to Collection

Review Pharmacology & Pharmacy

Pharmacokinetics of cyclodextrins and drugs after oral and parenteral administration of drug/cyclodextrin complexes

Thorsteinn Loftsson et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)

Add to Collection

Review Medicine, Research & Experimental

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

Jay Tibbitts et al.

MABS (2016)

Add to Collection

Review Toxicology

Oral uptake of nanoparticles: human relevance and the role of in vitro systems

Eleonore Froehlich et al.

ARCHIVES OF TOXICOLOGY (2016)

Add to Collection

Article Gastroenterology & Hepatology

Physiology of Intestinal Absorption and Secretion

Pawel R. Kiela et al.

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2016)

Add to Collection

Article Engineering, Biomedical

ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug

Jong Hyun Lee et al.

BIOMATERIALS (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Approaches to the Stabilization of Bioactive Epitopes by Grafting and Peptide Cyclization

Anne C. Conibear et al.

BIOPOLYMERS (2016)

Add to Collection

Article Pharmacology & Pharmacy

Development of oral self nano-emulsifying delivery system(s) of lanreotide with improved stability against presystemic thiol-disulfide exchange reactions

Muhammad Ijaz et al.

EXPERT OPINION ON DRUG DELIVERY (2016)

Add to Collection

Article Chemistry, Medicinal

Molecular descriptors for polarity: the need for going beyond polar surface area

Giulia Caron et al.

FUTURE MEDICINAL CHEMISTRY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Development of amphoteric alginate/aminated chitosan coated microbeads for oral protein delivery

A. M. Omer et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

Add to Collection

Article Pharmacology & Pharmacy

Zein-alginate based oral drug delivery systems: Protection and release of therapeutic proteins

Sungmun Lee et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

Abhijit A. Date et al.

JOURNAL OF CONTROLLED RELEASE (2016)

Add to Collection

Article Multidisciplinary Sciences

Synchronized cycles of bacterial lysis for in vivo delivery

M. Omar Din et al.

NATURE (2016)

Add to Collection

Review Pharmacology & Pharmacy

A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

Abdul Muheem et al.

SAUDI PHARMACEUTICAL JOURNAL (2016)

Add to Collection

Article Oncology

β-casein nanovehicles for oral delivery of chemotherapeutic Drug combinations overcoming P-glycoprotein-mediated multidrug resistance in human gastric cancer cells

Maya Bar-Zeev et al.

ONCOTARGET (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Ron Sender et al.

PLOS BIOLOGY (2016)

Add to Collection

Article Pharmacology & Pharmacy

Brush border membrane vesicle and Caco-2 cell line: Two experimental models for evaluation of absorption enhancing effects of saponins, bile salts, and some synthetic surfactants

Eskandar Moghimipour et al.

JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH (2016)

Add to Collection

Review Pharmacology & Pharmacy

Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches

Seth Amidon et al.

AAPS PHARMSCITECH (2015)

Add to Collection

Article Chemistry, Applied

Inclusion complex of erlotinib with sulfobutyl ether-β-cyclodextrin: Preparation, characterization, in silico, in vitro and in vivo evaluation

Naresh Devasari et al.

CARBOHYDRATE POLYMERS (2015)

Add to Collection

Article Pharmacology & Pharmacy

Multifunctional Delivery Systems for Advanced oral Uptake of Peptide/Protein Drugs

Jin Woo Park et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Add to Collection

Review Pharmacology & Pharmacy

Self-emulsifying drug delivery systems in oral (poly)peptide drug delivery

Gintare Leonaviciute et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

Add to Collection

Article Biochemistry & Molecular Biology

pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery

Piyasi Mukhopadhyay et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

Add to Collection

Article Pharmacology & Pharmacy

Casein/pectin nanocomplexes as potential oral delivery vehicles

Yangchao Luo et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Add to Collection

Article Medicine, Research & Experimental

Toward Oral Delivery of Biopharmaceuticals: An Assessment of the Gastrointestinal Stability of 17 Peptide Drugs

Jie Wang et al.

MOLECULAR PHARMACEUTICS (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Absorption-Enhancing Effects of Bile Salts

Eskandar Moghimipour et al.

MOLECULES (2015)

Add to Collection

Article Chemistry, Multidisciplinary

An intestinal Trojan horse for gene delivery

Haisheng Peng et al.

NANOSCALE (2015)

Add to Collection

Article Materials Science, Biomaterials

Temperature-sensitive polypeptide nanogels for intracellular delivery of a biomacromolecular drug

Du Young Ko et al.

JOURNAL OF MATERIALS CHEMISTRY B (2015)

Add to Collection

Review Pharmacology & Pharmacy

Physicochemical and Formulation Developability Assessment for Therapeutic Peptide Delivery-A Primer

Annette Bak et al.

AAPS JOURNAL (2015)

Add to Collection

Article Multidisciplinary Sciences

Properties of Protein Drug Target Classes

Simon C. Bull et al.

PLOS ONE (2015)

Add to Collection

Review Immunology

The gut microbiota and inflammatory bowel disease

Katsuyoshi Matsuoka et al.

SEMINARS IN IMMUNOPATHOLOGY (2015)

Add to Collection

Article Materials Science, Biomaterials

Ex Vivo Culture of Primary Intestinal Stem Cells in Collagen Gels and Foams

Haisheng Peng et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2015)

Add to Collection

Review Biotechnology & Applied Microbiology

A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules

Bibi F. Choonara et al.

BIOTECHNOLOGY ADVANCES (2014)

Add to Collection

Article Pharmacology & Pharmacy

Oral absorption enhancement of salmon calcitonin by using both N-trimethyl chitosan chloride and oligoarginines-modified liposomes as the carriers

Aiwen Huang et al.

DRUG DELIVERY (2014)

Add to Collection

Review Pharmacology & Pharmacy

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

Andreas Baumann et al.

DRUG DISCOVERY TODAY (2014)

Add to Collection

Article Pharmacology & Pharmacy

The role of citric acid in oral peptide and protein formulations: Relationship between calcium chelation and proteolysis inhibition

Soren H. Welling et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Add to Collection

Review Pharmacology & Pharmacy

Orally active-targeted drug delivery systems for proteins and peptides

Xiuying Li et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

Add to Collection

Review Immunology

Oral delivery of nanoparticle-based vaccines

Nirmal Marasini et al.

EXPERT REVIEW OF VACCINES (2014)

Add to Collection

Review Immunology

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

Thaher Pelaseyed et al.

IMMUNOLOGICAL REVIEWS (2014)

Add to Collection

Review Biochemistry & Molecular Biology

Prevention and treatment of postmenopausal osteoporosis

Sri Harsha Tella et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2014)

Add to Collection

Article Gastroenterology & Hepatology

Inflammatory bowel disease: Pathogenesis

Yi-Zhen Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Add to Collection

Review Pharmacology & Pharmacy

Mechanism of oral tolerance induction to therapeutic proteins

Xiaomei Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Add to Collection

Review Pharmacology & Pharmacy

Fatty acids as therapeutic auxiliaries for oral and parenteral formulations

Michael J. Hackett et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Regulation of intestinal epithelial permeability by tight junctions

Takuya Suzuki

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Add to Collection

Review Pharmacology & Pharmacy

Oral delivery of therapeutic proteins and peptides: a review on recent developments

Sonal Gupta et al.

DRUG DELIVERY (2013)

Add to Collection

Review Pharmacology & Pharmacy

Injectable implants for the sustained release of protein and peptide drugs

Priyanka Agarwal et al.

DRUG DISCOVERY TODAY (2013)

Add to Collection

Article Pharmacology & Pharmacy

Oral delivery of therapeutic protein/peptide for diabetes - Future perspectives

M. R. Rekha et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Add to Collection

Review Pharmacology & Pharmacy

Approaches for enhancing oral bioavailability of peptides and proteins

Jwala Renukuntla et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Add to Collection

Review Immunology

Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium

N. A. Mabbott et al.

MUCOSAL IMMUNOLOGY (2013)

Add to Collection

Review Pharmacology & Pharmacy

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

Arnaud E. Felber et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Add to Collection

Review Pharmacology & Pharmacy

Oral drug delivery utilizing intestinal OATP transporters

Ikumi Tamai

ADVANCED DRUG DELIVERY REVIEWS (2012)

Add to Collection

Article Engineering, Biomedical

The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems

Mirkka P. Sarparanta et al.

BIOMATERIALS (2012)

Add to Collection

Review Chemistry, Medicinal

The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review

Naseem Akhtar et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2011)

Add to Collection

Article Gastroenterology & Hepatology

Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan

Michio Hongo et al.

JOURNAL OF GASTROENTEROLOGY (2010)

Add to Collection

Review Immunology

Peyer's Patches: The Immune Sensors of the Intestine

Camille Jung et al.

INTERNATIONAL JOURNAL OF INFLAMMATION (2010)

Add to Collection

Review Chemistry, Multidisciplinary

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

Paul D. W. Eckford et al.

CHEMICAL REVIEWS (2009)

Add to Collection

Article Engineering, Biomedical

PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

Ryan G. Soderquist et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2009)

Add to Collection

Article Multidisciplinary Sciences

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

Benjamin C. Tang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Add to Collection

Biographical-Item Biochemistry & Molecular Biology

DDAVP (Desmopressin) and solid phase peptide synthesis

Milan Zaoral

BIOPOLYMERS (2008)

Add to Collection

Article Anesthesiology

Effect of microneedle design on pain in human volunteers

Harvinder S. Gill et al.

CLINICAL JOURNAL OF PAIN (2008)

Add to Collection

Review Pharmacology & Pharmacy

Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms

Bo Tang et al.

DRUG DISCOVERY TODAY (2008)

Add to Collection

Review Pharmacology & Pharmacy

Protein and Peptide Drug Delivery: Oral Approaches

Jessy Shaji et al.

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Add to Collection

Article Engineering, Biomedical

Chitosan/polyethylene glycol blend fibers and their properties for drug controlled release

Qun Wang et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2008)

Add to Collection

Article Multidisciplinary Sciences

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Malin E. V. Johansson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Matrix metalloproteinase expression and function during fin regeneration in zebrafish: Analysis of MT1-MMP, MMP2 and TIMP2

S Bai et al.

MATRIX BIOLOGY (2005)

Add to Collection

Article Chemistry, Multidisciplinary

Bloadhesive interaction and hypoglycemic effect of insulin-loaded lectin-microparticle conjugates in oral insulin delivery system

BY Kim et al.

JOURNAL OF CONTROLLED RELEASE (2005)

Add to Collection

Review Pharmacology & Pharmacy

Intestinal Peyer's patch M cells and oral vaccine targeting

DJ Brayden et al.

DRUG DISCOVERY TODAY (2005)

Add to Collection

Review Pharmacology & Pharmacy

Thiomers:: potential excipients for non-invasive peptide delivery systems

A Bernkop-Schnürch et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2004)

Add to Collection

Review Chemistry, Multidisciplinary

Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation

EY Chi et al.

PHARMACEUTICAL RESEARCH (2003)

Add to Collection

Article Engineering, Biomedical

Novel complexation hydrogels for oral peptide delivery: In vitro evaluation of their cytocompatibility and insulin-transport enhancing effects using Caco-2 cell monolayers

H Ichikawa et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2003)

Add to Collection

Article Pharmacology & Pharmacy

Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass

VM Leitner et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2003)

Add to Collection

Article Obstetrics & Gynecology

Absorption and distribution of dietary fatty acids from different sources

M Ramírez et al.

EARLY HUMAN DEVELOPMENT (2001)

Add to Collection

Reprint Pharmacology & Pharmacy

Delivery systems for penetration enhancement of peptide and protein drugs: design considerations (Reprinted from Advanced Drug Delivery Reviews, vol 8, pg 115-162, 1992)

UB Kompella et al.

ADVANCED DRUG DELIVERY REVIEWS (2001)

Add to Collection

Article Engineering, Biomedical

Enhancing effect of chitosan on peptide drug delivery across buccal mucosa

S Senel et al.

BIOMATERIALS (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.