4.5 Article

A negative feedback loop centered on SMAD3 expression in transforming growth factor 81-induced corneal myofibroblast differentiation

Related references

Note: Only part of the references are listed.
Article Cell Biology

Effect of porcine corneal stromal extract on keratocytes from SMILE-derived lenticules

Shenyang Li et al.

Summary: A novel medium was developed to propagate human corneal stromal cells (hCSCs) while maintaining their physiological quality, showing potential for clinical cell therapy. The study demonstrated that intrastromal injection of hCSCs in this medium has beneficial effects on cell proliferation and potential for future therapeutic applications.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Ophthalmology

Effect of isolation method on human corneal stromal cell behaviour

Thomas L. A. Volatier et al.

Summary: Research on healthy corneal stromal cells often utilizes primary cells isolated from donor peripheral corneal tissue, but the extraction method and location of stromal cells harvested can significantly impact cell behavior and gene expression in culture. Enzyme digestion of limbal tissue seems to produce stromal cells with desirable characteristics for primary cell culture.

EXPERIMENTAL EYE RESEARCH (2021)

Article Ophthalmology

Corneal stromal wound healing: Major regulators and therapeutic targets

Sabeeh Kamil et al.

Summary: Corneal stromal wound healing is a complex process involving apoptosis, proliferation, migration, and transdifferentiation of keratocytes. The central player guiding stromal responses is TGF-beta signaling, while other major regulators include myofibroblasts, basement membrane, collagen fibrils, and small leucine-rich proteoglycans. Understanding the roles of these regulators has helped develop novel therapies to prevent corneal opacity.

OCULAR SURFACE (2021)

Article Ophthalmology

Corneal myofibroblasts and fibrosis

Steven E. Wilson

EXPERIMENTAL EYE RESEARCH (2020)

Article Ophthalmology

Corneal fibroblasts: Function and markers

Ken Fukuda

EXPERIMENTAL EYE RESEARCH (2020)

Review Ophthalmology

Fibrocytes, Wound Healing, and Corneal Fibrosis

Rodrigo Carlos de Oliveira et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

Specificity, versatility, and control of TGF-β family signaling

Rik Derynck et al.

SCIENCE SIGNALING (2019)

Article Cell Biology

Modulation of TGFβ/Smad signaling by the small GTPase RhoB

Melina Livitsanou et al.

CELLULAR SIGNALLING (2018)

Article Ophthalmology

Inhibition of Human Corneal Myofibroblast Formation

Xiaoqing Guo et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Article Cell Biology

Signaling Cross Talk between TGF-beta/Smad and Other Signaling Pathways

Kunxin Luo

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Article Cell Biology

Non-Smad Signaling Pathways of the TGF-β Family

Ying E. Zhang

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Article Ophthalmology

Molecular insights on the effect of TGF-β1/-β3 in human corneal fibroblasts

Xiaoqing Guo et al.

EXPERIMENTAL EYE RESEARCH (2016)

Review Ophthalmology

The corneal fibrosis response to epithelial-stromal injury

Andre A. M. Torricelli et al.

EXPERIMENTAL EYE RESEARCH (2016)

Review Urology & Nephrology

TGF-β: the master regulator of fibrosis

Xiao-ming Meng et al.

NATURE REVIEWS NEPHROLOGY (2016)

Article Ophthalmology

Corneal structure and transparency

Keith M. Meek et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2015)

Article Obstetrics & Gynecology

Smad7 is a transforming growth factor-beta-inducible mediator of apoptosis in granulosa cells

Marisol Quezada et al.

FERTILITY AND STERILITY (2012)

Review Cell Biology

TGFβ signalling in context

Joan Massague

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Cell Biology

Non-Smad pathways in TGF-beta signaling

Ying E. Zhang

CELL RESEARCH (2009)

Article Biochemistry & Molecular Biology

TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β

Motozo Yamashita et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

Identification and characterization of a general nuclear translocation signal in signaling proteins

Dana Chuderland et al.

MOLECULAR CELL (2008)

Review Cell Biology

Corneal crystallins and the development of cellular transparency

James V. Jester

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcA

Matt K. Lee et al.

EMBO JOURNAL (2007)

Article Gastroenterology & Hepatology

Identification of apoptotic genes mediating TGF-β/Smad3-induced cell death in intestinal epithelial cells using a genomic approach

Yanna Cao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

The keratocyte: Corneal stromal cell with variable repair phenotypes

Judith A. West-Mays et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

Article Ophthalmology

Corneal keratocytes: Phenotypic and species differences in abundant protein expression and in vitro light-scattering

JV Jester et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)

Article Cell Biology

Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3

BM Stramer et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2005)

Article Ophthalmology

Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium

S Saika et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2004)

Review Multidisciplinary Sciences

Smad-dependent and Smad-independent pathways in TGF-β family signalling

R Derynck et al.

NATURE (2003)

Review Biochemistry & Molecular Biology

Mechanisms of TGF-β signaling from cell membrane to the nucleus

YG Shi et al.

Article Biochemistry & Molecular Biology

TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines

SP Fink et al.

ONCOGENE (2003)

Article Biochemistry & Molecular Biology

Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation

M Tobe et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

TGF-β receptor-activated p38 MAP kinase mediates smad-independent TGF-β responses

L Yu et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis:: a negative feedback loop of TGF-β signaling

Y Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Multidisciplinary Sciences

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

BL Bennett et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Pharmacology & Pharmacy

SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance

M Barancík et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2001)

Article Biochemistry & Molecular Biology

Importin β mediates nuclear translocation of Smad 3

Z Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)