Journal
METABOLIC BRAIN DISEASE
Volume 31, Issue 2, Pages 445-454Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-015-9785-7
Keywords
Neuroinflammation; Hippocampus; Stress; Glucocorticoid; Corticosterone
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Funding
- Russian Science Foundation [14-25-00136]
- Russian Science Foundation [14-25-00136] Funding Source: Russian Science Foundation
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Hippocampus is believed to be selectively vulnerable to stress. We hypothesized that this phenomenon may be mediated by relatively high vulnerability to neuroinflammation related to impairments of local glucocorticoid metabolism and signaling. We have evaluated inflammatory responses induced by acute or chronic combined stress in the cerebral cortex and hippocampus as well as circulating and brain corticosterone (CS) levels as well as expression of corticosterone target genes. The hippocampus showed higher stress-induced expression of the proinflammatory cytokine IL-1 beta as compared to the cerebral cortex. A month after the termination of the chronic stress, IL-1 beta mRNA in the cerebral cortex reached control level, while in the hippocampus it remained significantly increased. Under chronic stress, the maladaptive inflammatory response in hippocampus was accompanied by a significant increase in local CS levels, as compared to cerebral cortex. Under acute stress, the increased CS level induced changes in CS-regulated genes expression (CRF and IGF1), while this phenomenon was not observed after chronic stress. Thus, the hippocampus appears to be more vulnerable to stress-induced inflammation as compared to the neocortex and demonstrates persistent inflammatory response induced by chronic stress. Stress-induced maladaptive inflammatory response is associated with a selective increase in hippocampal CS accumulation and changes in CS signaling.
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