4.6 Article

Revisiting asthma pharmacotherapy: where do we stand and where do we want to go?

Journal

EUROPEAN RESPIRATORY JOURNAL
Volume 62, Issue 2, Pages -

Publisher

EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/13993003.00700-2023

Keywords

-

Ask authors/readers for more resources

Current guidelines and strategies for asthma treatment primarily focus on improving lung function and reducing symptoms. However, they fail to address the underlying mechanisms of this heterogeneous disease. It is necessary to re-evaluate the current one-size-fits-all approach and develop more personalized asthma management.
Several current guidelines/strategies outline a treatment approach to asthma, which primarily consider the goals of improving lung function and quality of life and reducing symptoms and exacerbations. They suggest a strategy of stepping up or down treatment, depending on the patient's overall current asthma symptom control and future risk of exacerbation. While this stepwise approach is undeniably practical for daily practice, it does not always address the underlying mechanisms of this heterogeneous disease. In the last decade, there have been attempts to improve the treatment of severe asthma, such as the addition of a long-acting antimuscarinic agent to the traditional inhaled corticosteroid/long-acting & beta;2-agonist treatment and the introduction of therapies targeting key cytokines. However, despite such strategies several unmet needs in this population remain, motivating research to identify novel targets and develop improved therapeutic and/or preventative asthma treatments. Pending the availability of such therapies, it is essential to re-evaluate the current conventional one-size-fits-all approach to a more precise asthma management. Although challenging, identifying treatable traits that contribute to respiratory symptoms in individual patients with asthma may allow a more pragmatic approach to establish more personalised therapeutic goals.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available