Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 62, Pages 12439-12442Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04545b
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Funding
- Cancer Prevention Research Institute of Texas [RP130604]
- National Institute of Biomedical Imaging and Bioengineering [1R01EB014354-01A1]
- National Cancer Institute [P30-CA016086-35-37]
- Biomedical Research Imaging Center, University of North Carolina at Chapel Hill
- Development and Promotion of Science and Technology (DPST) program
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The radiofluorination of N-heterocyclic carbene (NHC) boron trifluoride adducts affords novel [F-18]-positron emission tomography probes which resist hydrolytic fluoride release. The labelling protocol relies on an F-18-F-19 isotopic exchange reaction promoted by the Lewis acid SnCl4. Modification of the NHC backbone with a maleimide functionality provides access to a model peptide conjugate which shows no evidence of defluorination when imaged in vivo.
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