Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 8, Pages 1453-1456Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08746a
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Funding
- National Natural Science Foundation of China [31300786]
- National Science Foundation for Post-doctor [2013M541961]
- Applied Basic Research Plan of Qingdao [14-2-4-98-jch]
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A novel hyaluronic acid modified transfersome was prepared to deliver drugs to lymphatics through the transdermal route. Doxorubicin loaded HA-GMS-T was able to efficiently penetrate into the deep skin tissue, leading to enhanced absorption by lymphatics. Most importantly, hyaluronic acid effectively improved the uptake of drug loaded nanocarriers by tumor cells.
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