4.7 Article

Dynamic flow synthesis of porous organic cages

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 98, Pages 17390-17393

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc07447a

Keywords

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Funding

  1. Engineering and Physical Sciences Research Council (EPSRC) [EP/H000925/1, EP/K009494/1, EP/M004120/1]
  2. Pfizer Worldwide Research Development
  3. EPSRC Dial-a-Molecule Grand Challenge Network [EP/K004840/1]
  4. EPSRC [EP/K009494/1, EP/H000925/1, EP/K004840/1] Funding Source: UKRI
  5. Engineering and Physical Sciences Research Council [EP/H000925/1, EP/K004840/1, EP/K009494/1] Funding Source: researchfish

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The dynamic covalent synthesis of two imine-based porous organic cages was successfully transferred from batch to continuous flow. The same flow reactor was then used to scramble the constituents of these two cages in differing ratios to formcage mixtures. Preparative HPLC purification of one of these mixtures allowed rapid access to a desymmetrised cage molecule.

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