4.7 Article

221S-1a inhibits endothelial proliferation in pathological angiogenesis through ERK/c-Myc signaling

Related references

Note: Only part of the references are listed.
Article Neurosciences

Danshensu Enhances Cerebral Angiogenesis in Mice by Regulating the PI3K/Akt/Mtor/VEGF Signaling Axis

Hongning Jia et al.

Summary: Danshensu promotes angiogenesis in cerebral ischemic injury through the PI3K/Akt/mTOR/VEGF signaling pathway.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2023)

Article Plant Sciences

Exploring the synergic mechanism of Ligusticum striatum DC. and borneol in attenuating BMECs injury and maintaining tight junctions against cerebral ischaemia based on the HIF-1?/VEGF signalling pathway

Xiaoxiong Song et al.

Summary: This study aims to explore the synergistic effect of the combination of Ligusticum striatum DC. and borneol in maintaining the blood-brain barrier (BBB) after ischemic stroke (IS) and to investigate the potential underlying mechanism.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Article Medicine, Research & Experimental

Captopril alleviates oxidative damage in diabetic retinopathy

Xiang Gao et al.

Summary: This study demonstrates that captopril alleviates oxidative damage in diabetic retinopathy by reducing reactive oxygen species (ROS) and nitric oxide (NO) levels, thereby reducing peroxynitrite formation. These findings provide new directions for research in diabetic retinopathy.

LIFE SCIENCES (2022)

Article Pharmacology & Pharmacy

Peptides derived from sea cucumber accelerate cells proliferation and migration for wound healing by promoting energy metabolism and upregulating the ERK/AKT pathway

Zhihong Zheng et al.

Summary: This study demonstrates that sea cucumber-derived tetrapeptides VTPY and VLLY have the ability to promote the proliferation and migration of human skin fibroblasts and human umbilical vein endothelial cells. The mechanism behind this involves improving mitochondrial respiratory capacity, increasing ATP production, and blocking specific protein interactions to upregulate the ERK/AKT signaling pathway.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Article Medicine, Research & Experimental

Myeloid cell modulation by a GLP-1 receptor agonist regulates retinal angiogenesis in ischemic retinopathy

Lingli Zhou et al.

Summary: The study revealed the involvement of mononuclear phagocytes (MPs) in diabetic retinopathy and ischemia-induced retinopathy, and demonstrated that the GLP-1R agonist NLY01 can modulate MPs to promote reparative angiogenesis. These findings suggest that modulation of MPs could be a potential new treatment strategy for ischemic retinopathies.

JCI INSIGHT (2021)

Article Oncology

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Joanne M. Munck et al.

Summary: ASTX029 is a highly potent and selective dual-mechanism ERK inhibitor that targets MAPK-activated cancers by inhibiting both ERK catalytic activity and phosphorylation by MEK. It has shown significant antitumor activity in both in vitro and in vivo models, including acquired resistance to MAPK pathway inhibitors. ASTX029 is currently undergoing evaluation in a clinical trial for patients with advanced solid tumors.

MOLECULAR CANCER THERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

Emerging roles of PLCγ1 in endothelial biology

Dongying Chen et al.

Summary: PLC gamma 1, a member of the PLC family, plays a crucial role as a signal transducer by hydrolyzing membrane lipid to generate second messengers. Deficiency of PLC gamma 1 in animal models and gain-of-function mutations in human endothelial cancers highlight its significant physiological role in the endothelial system. Understanding the physiological and molecular functions of PLC gamma 1 can provide insights for future research in the context of endothelial cells.

SCIENCE SIGNALING (2021)

Article Medicine, Research & Experimental

Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis

Xue Dong et al.

Summary: The study utilized exosomes (EXOs) as carriers for delivering the anti-angiogenic peptide KV11 via retro-orbital injection, showing enhanced suppression of neovascularization and vascular leakage in the retina. This system has the potential to treat proliferative retinopathy in a less invasive manner compared to intravitreal injection.

THERANOSTICS (2021)

Review Cell Biology

ERK signalling: a master regulator of cell behaviour, life and fate

Hugo Lavoie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Review Medicine, Research & Experimental

Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases

Asghar Fallah et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Pharmacology & Pharmacy

Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis

Xiaozhong Huang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Oncology

Contribution of Angiogenesis to Inflammation and Cancer

Dolores Aguilar-Cazares et al.

FRONTIERS IN ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

Chloe J. Peach et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Integrative & Complementary Medicine

Esculetin Inhibits VEGF-Induced Angiogenesis Both In Vitro and In Vivo

Sung Lyea Park et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2016)

Review Cell Biology

Mechanisms and regulation of endothelial VEGF receptor signalling

Michael Simons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Myc and cell cycle control

Gabriel Bretones et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)

Article Pharmacology & Pharmacy

A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway

Qian Yin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

Review Surgery

Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis

Sang Hun Lee et al.

ANNALS OF SURGICAL TREATMENT AND RESEARCH (2015)

Article Biochemistry & Molecular Biology

A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics

Apirat Chaikuad et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs

Joerg Hackermueller et al.

GENOME BIOLOGY (2014)

Article Integrative & Complementary Medicine

Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo

Benjamin Krusche et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Hematology

NHERF-2 maintains endothelial homeostasis

Resham Bhattacharya et al.

BLOOD (2012)

Article Oncology

Effect of VEGF and VEGF Trap on vascular endothelial cell signaling in tumors

Wiem Lassoued et al.

CANCER BIOLOGY & THERAPY (2010)

Article Endocrinology & Metabolism

Blockade of angiotensin II attenuates VEGF-mediated blood-retinal barrier breakdown in diabetic retinopathy

Jeong Hun Kim et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2009)

Article Medicine, Research & Experimental

Influence of Borneol on In Vitro Corneal Permeability and on In Vivo and In Vitro Corneal Toxicity

H. Yang et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2009)

Review Biochemistry & Molecular Biology

What tangled webs they weave: Rho-GTPase control of angiogenesis

B. A. Bryan et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

Review Biotechnology & Applied Microbiology

Opinion - Angiogenesis: an organizing principle for drug discovery?

Judah Folkman

NATURE REVIEWS DRUG DISCOVERY (2007)

Article Biochemistry & Molecular Biology

Live cell imaging of ERK and MEK

WR Burack et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice

Y Sakurai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Oncology

Anti-tumor activity of a combination of plasminogen activator and captopril in a human melanoma xenograft model

RRJ De Groot-Besseling et al.

INTERNATIONAL JOURNAL OF CANCER (2004)

Article Oncology

In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril

JR Merchan et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)