Forkhead box proteins as the critical regulators of cisplatin response in tumor cells

Cisplatin (CDDP) is one of the most common chemotherapy drugs used in a wide range of cancer patients; however, there is a high rate of CDDP resistance among cancer patients. Considering the side effects of cisplatin in normal tissues, it is necessary to predict the CDDP response in cancer patients. Therefore, identifying the molecular mechanisms involved in CDDP resistance can help to introduce the prognostic markers. Several molecular mechanisms such as apoptosis inhibition, drug efflux, drug detoxification, and increased DNA repair are involved in CDDP resistance. Regarding the key role of transcription factors in regulation of many cellular processes related to drug resistance, in the present review, we discussed the role of Forkhead box (FOX) protein family in CDDP response. It has been reported that FOX proteins mainly promote CDDP resistance through the regulation of DNA repair, autophagy, epithelial-mesenchymal transition (EMT), and signaling pathways. Therefore, FOX proteins can be introduced as the prognostic markers to predict CDDP response in cancer patients. In addition, considering that oncogenic role of FOX proteins, the CDDP treatment along with FOX inhibition can be used as a therapeutic strategy in cancer patients.

Automated summary

Cisplatin (CDDP) is a commonly used chemotherapy drug, but there is a high rate of CDDP resistance among cancer patients. Identifying the molecular mechanisms involved in CDDP resistance, particularly the role of FOX protein family, can help predict CDDP response and introduce prognostic markers. FOX proteins mainly promote CDDP resistance through regulation of DNA repair, autophagy, epithelial-mesenchymal transition (EMT), and signaling pathways. Inhibition of FOX proteins can be considered as a therapeutic strategy in cancer patients undergoing CDDP treatment.