Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202300597
Keywords
homogeneous catalysis; manganese; pincer complex; quinolines; transfer hydrogenation
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Here, an efficient method for the homogeneous manganese-catalysed transfer hydrogenation of N-heterocycles using ammonia-borane as a hydrogen source under mild reaction conditions is reported. The use of a PNP manganese pincer complex allows for good to excellent isolated yields. The reaction proceeds through the detection of 1,2-dihydroquinoline as an intermediate by NMR spectra analysis and deuterium labelling experiment.
Herein, an efficient methodology for the homogeneous manganese-catalysed transfer hydrogenation of N-heterocycles by using ammonia-borane as a hydrogen source under mild reaction conditions is reported. Good to excellent isolated yields are achieved by applying a PNP manganese pincer complex. In the reaction, 1,2-dihydroquinoline is detected as intermediate by NMR spectra analysis and deuterium labelling experiment. The catalytic reaction likely proceeded by an outer-sphere pathway based on the bifunctional pincer complex. A PNP pincer manganese complex was applied as catalyst for transfer hydrogenation of quinolines with ammonia borane as hydrogen source. 1,2,3,4-Tetrahydroquinolines were obtained under mild conditions with good to excellent yields. 1,2-Dihydroquinolines were detected by 1H NMR in the progress and isotopic labelling experiments were performed to determine the destination of ammonia-borane hydrogen atoms.image
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