4.7 Article

Nanoscale UiO-MOF-based luminescent sensors for highly selective detection of cysteine and glutathione and their application in bioimaging

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 100, Pages 17672-17675

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc07783d

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Funding

  1. NSFC [21475078, 21271120, 21301109]
  2. 973 Program [2012CB821705, 2013CB933800]
  3. Taishan scholar's

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We report a practical approach, the first of its kind, to construct nanoscale UiO-type metal-organic framework (Mi-UiO-66 and Mi-UiO-67) fluorescent probes for the detection of Cys and GSH. They showed high sensitivity (10(-11) M) and selectivity for Cys and GSH, and their fluorescence imaging of Cys and GSH in living cells was well demonstrated.

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