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Hydrophobic tag-based protein degradation: Development, opportunity and challenge

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

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NATURE CHEMICAL BIOLOGY (2014)

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Targeted protein destabilization reveals an estrogen-mediated ER stress response

Kanak Raina et al.

NATURE CHEMICAL BIOLOGY (2014)

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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Jan Kroenke et al.

SCIENCE (2014)

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Aryl hydrocarbon receptor ligands in cancer: friend and foe

Iain A. Murray et al.

NATURE REVIEWS CANCER (2014)

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Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: Glycoprotein glucosyltransferase (UGGT)

Maria B. Prados et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

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The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

Lukas Wanka et al.

CHEMICAL REVIEWS (2013)

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High Lipophilicity and High Daily Dose of Oral Medications Are Associated With Significant Risk for Drug-Induced Liver Injury

Minjun Chen et al.

HEPATOLOGY (2013)

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The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

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NUCLEIC ACIDS RESEARCH (2013)

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Artemether-Lumefantrine: An Option for Malaria

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ANNALS OF PHARMACOTHERAPY (2012)

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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

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CANCER RESEARCH (2012)

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Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

Hyun Seop Tae et al.

CHEMBIOCHEM (2012)

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Inhibitor Mediated Protein Degradation

Marcus J. C. Long et al.

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CRABP-II- and FABP5-independent all-trans retinoic acid resistance in COLO 16 human cutaneous squamous cancer cells

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EXPERIMENTAL DERMATOLOGY (2012)

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The influence of lipophilicity in drug discovery and design

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EXPERT OPINION ON DRUG DISCOVERY (2012)

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Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

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LEUKEMIA (2012)

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CHEMICAL BIOLOGY Greasy tags for protein removal

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Complete subunit architecture of the proteasome regulatory particle

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Claudio Hetz

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Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells

Andrew J. Holland et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Delineation of the Core Aggregation Sequences of TDP-43 C-Terminal Fragment

Akash Saini et al.

CHEMBIOCHEM (2011)

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Carbaboranes as Pharmacophores: Properties, Synthesis, and Application Strategies

Matthias Scholz et al.

CHEMICAL REVIEWS (2011)

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Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds

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CHEMICAL REVIEWS (2011)

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Boron Cluster-based Development of Potent Nonsecosteroidal Vitamin D Receptor Ligands: Direct Observation of Hydrophobic Interaction between Protein Surface and Carborane

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Exposed hydrophobicity is a key determinant of nuclear quality control degradation

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MOLECULAR BIOLOGY OF THE CELL (2011)

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Pyrene: A Probe to Study Protein Conformation and Conformational Changes

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MOLECULES (2011)

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Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins

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NATURE CHEMICAL BIOLOGY (2011)

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TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

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TRENDS IN MOLECULAR MEDICINE (2011)

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β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: Improvement of solubility by disruption of molecular planarity

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BIOORGANIC & MEDICINAL CHEMISTRY (2010)

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Discovery of Carboranes as Inducers of 20S Proteasome Activity

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CHEMMEDCHEM (2010)

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NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets

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AUTOPHAGY (2009)

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SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples

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CANCER CHEMOTHERAPY AND PHARMACOLOGY (2009)

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Quality Control Against Misfolded Proteins in the Cytosol: A Network for Cell Survival

Hiroshi Kubota

JOURNAL OF BIOCHEMISTRY (2009)

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Fluorene-Based Materials and Their Supramolecular Properties

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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2009)

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Hydrophobic statins induce autophagy in cultured human rhabdomyosarcoma cells

Makoto Araki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

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Structural basis for the function and inhibition of an influenza virus proton channel (vol 451, pg 596, 2008)

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NATURE (2008)

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Autophagy: process and function

Noboru Mizushima

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The menthol receptor TRPM8 is the principal detector of environmental cold

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Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

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A quantitative assessment of hERG liability as a function of lipophilicity

Michael J. Waring et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

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Boron units as pharmacophores - New applications and opportunities of boron cluster chemistry

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COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS (2007)

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Protein-misfolding diseases and chaperone-based therapeutic approaches

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FEBS JOURNAL (2006)

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Rapid screening of blood-brain barrier penetration of drugs using the immobilized artificial membrane phosphatidylcholine column chromatography

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Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: Potential DNA intercalators

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Carcinogenicity of polycyclic aromatic hydrocarbons

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LANCET ONCOLOGY (2005)

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Polycyclic aromatic hydrocarbons and fatal ischemic heart disease

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EPIDEMIOLOGY (2005)

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A possible mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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A new class of androgen receptor antagonists bearing carborane in place of a steroidal skeleton

S Fujii et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

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Synthetic substrates for an endoplasmic reticulum protein-folding sensor, UDP-glucose: Glycoprotein glucosyltransferase

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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)

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Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

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NATURE IMMUNOLOGY (2003)

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Translocation of liposomes into cancer cells by cell-penetrating peptides penetratin and TAT: A kinetic and efficacy study

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MOLECULAR PHARMACOLOGY (2002)

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Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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