4.7 Review

Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery

Journal

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 260, Issue -, Pages -

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2023.115791

Keywords

Natural product; Flavonoids; Anti-inflammatory activities; Scaffolds; Drug discovery; Targets

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This review provides a comprehensive overview of the diverse anti-inflammatory activities of flavonoids and elucidates the underlying pathways in mediating inflammation. It includes a systematic classification and detailed statistical analysis of flavonoids, related anti-inflammatory targets, and in vitro and in vivo test models. The review aims to provide practical information and potential leads for researchers engaged in natural products and anti-inflammatory drug discovery.
Natural products have been utilized for medicinal purposes for millennia, endowing them with a rich source of chemical scaffolds and pharmacological leads for drug discovery. Among the vast array of natural products, flavonoids represent a prominent class, renowned for their diverse biological activities and promising therapeutic advantages. Notably, their anti-inflammatory properties have positioned them as promising lead compounds for developing novel drugs combating various inflammatory diseases. This review presents a comprehensive overview of flavonoids, highlighting their manifold anti-inflammatory activities and elucidating the underlying pathways in mediating inflammation. Furthermore, this review encompasses systematical classification of flavonoids, related anti-inflammatory targets, involved in vitro and in vivo test models, and detailed statistical analysis. We hope this review will provide researchers engaged in active natural products and anti-inflammatory drug discovery with practical information and potential leads.

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