Related references
Note: Only part of the references are listed.Boron-Containing heterocycles as promising pharmacological agents
Bhaskar C. Das et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2022)
Applications of the Reversible Boronic Acids/Boronate Switch to Nucleic Acids
Megane Debiais et al.
CHEMICAL RECORD (2022)
Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates
Angel M. Padilla et al.
NATURE MICROBIOLOGY (2022)
An updated patent review of autotaxin inhibitors (2017-present)
Zehui Tan et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2021)
Recent developments in the medicinal chemistry of single boron atom-containing compounds
Shu Song et al.
ACTA PHARMACEUTICA SINICA B (2021)
Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores
You-Cai Xiao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Charles E. Mowbray et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis
Zhaoxing Chu et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
Preparation of Sulfamates and Sulfamides Using a Selective Sulfamoylation Agent
Hai-Ming Wang et al.
ORGANIC LETTERS (2021)
The Expression Regulation and Biological Function of Autotaxin
Xiaotian Zhang et al.
CELLS (2021)
Recent developments in the synthesis of bioactive boron-containing compounds
Liyang Ji et al.
TETRAHEDRON LETTERS (2021)
Protein Tyrosine Phosphatase (PTP1B): A promising Drug Target Against Life-threatening Ailments
Ajay Kumar et al.
CURRENT MOLECULAR PHARMACOLOGY (2020)
Boron Chemistry for Medical Applications
Fayaz Ali et al.
MOLECULES (2020)
Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation
Kirthana M. Sindhe et al.
MBIO (2020)
Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease
Hui Wei et al.
CURRENT MEDICAL SCIENCE (2020)
Design and discovery of boronic acid drugs
Jessica Plescia et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Squaramides as Bioisosteres in Contemporary Drug Design
Kylie A. Agnew-Francis et al.
CHEMICAL REVIEWS (2020)
Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications
Mariana Pereira Silva et al.
MOLECULES (2020)
Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites
Valeria Bellini et al.
ISCIENCE (2020)
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
Federica Giordani et al.
PLOS PATHOGENS (2020)
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor
Pek Y. Chong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents
Jiong Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Christopher S. Lunde et al.
NATURE COMMUNICATIONS (2019)
Benzoxaboroles as dynamic covalent receptors for bioconjugation and transport of nucleosides and related drugs: Proof of action in HeLa cells
Cecilia Samaniego Lopez et al.
BIOORGANIC CHEMISTRY (2019)
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Alen Krajnc et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Benzoxaboroles-Novel Autotaxin Inhibitors
Kristina Kraljic et al.
MOLECULES (2019)
The Chemistry of Boronic Acids in Nanomaterials for Drug Delivery
Alexandra Stubelius et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Multiresponsive and Self-Healing Hydrogel via Formation of Polymer-Nanogel Interfacial Dynamic Benzoxaborole Esters at Physiological pH
Yangjun Chen et al.
ACS APPLIED MATERIALS & INTERFACES (2019)
Boron in drug design: Recent advances in the development of new therapeutic agents
Guilherme Felipe Santos Fernandes et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection
Christopher Swale et al.
SCIENCE TRANSLATIONAL MEDICINE (2019)
Injectable, Self-Healing, and Multi-Responsive Hydrogels via Dynamic Covalent Bond Formation between Benzoxaborole and Hydroxyl Groups
Yangjun Chen et al.
BIOMACROMOLECULES (2019)
The Role of the Phosphorus Atom in Drug Design
Juan B. Rodriguez et al.
CHEMMEDCHEM (2019)
Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Tsutomu Akama et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Structure-based design of targeted covalent inhibitors
Richard Lonsdale et al.
CHEMICAL SOCIETY REVIEWS (2018)
Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors
Shilong Zheng et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Clinical and veterinary trypanocidal benzoxaboroles target CPSF3
Richard J. Wall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
Daniela Begolo et al.
PLOS PATHOGENS (2018)
Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid
Ian W. Windsor et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases
Heng Li et al.
FRONTIERS IN PHARMACOLOGY (2018)
Boron's journey: advances in the study and application of pharmacokinetics
Ana L. Ocampo-Nestor et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2017)
Autotaxin inhibitors: a patent review (2012-2016)
Aikaterini Nikolaou et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2017)
Structural Isosteres of Phosphate Groups in the Protein Data Bank
Yuezhou Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate
Yong-Kang Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation
Thomas P. Smith et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
The versatility of boron in biological target engagement
Diego B. Diaz et al.
NATURE CHEMISTRY (2017)
Rational design of first generation inhibitors for trehalose 6-phosphate phosphatases
Chunliang Liu et al.
TETRAHEDRON (2017)
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Ebere Sonoiki et al.
NATURE COMMUNICATIONS (2017)
Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis
Andres Palencia et al.
EMBO MOLECULAR MEDICINE (2017)
A new therapeutic for the treatment of moderate-to-severe plaque psoriasis: apremilast
Andrea Chiricozzi et al.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2016)
Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)
Jiawang Liu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults
Amy S. Paller et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2016)
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
Juergen Brem et al.
NATURE COMMUNICATIONS (2016)
The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
Verena Katharina Raker et al.
FRONTIERS IN IMMUNOLOGY (2016)
Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes
Chen Dong et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status
Qiu Zhong et al.
BMC CANCER (2015)
Boronic prodrug of endoxifen as an effective hormone therapy for breast cancer
Changde Zhang et al.
BREAST CANCER RESEARCH AND TREATMENT (2015)
Boron-Based Drug Design
Hyun Seung Ban et al.
CHEMICAL RECORD (2015)
Recent Developments in the Chemistry and Biological Applications of Benzoxaboroles
Agnieszka Adamczyk-Wozniak et al.
CHEMICAL REVIEWS (2015)
Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Yong-Kang Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
The unique chemistry of benzoxaboroles: Current and emerging applications in biotechnology and therapeutic treatments
C. Tony Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Phosphorothioate Oligonucleotides: Effectiveness and Toxicity
Tommaso Iannitti et al.
CURRENT DRUG TARGETS (2014)
Delineating the Structural Blueprint of the Pre-mRNA 3′-End Processing Machinery
Kehui Xiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Kinase Drug Discovery - What's Next in the Field?
Philip Cohen et al.
ACS CHEMICAL BIOLOGY (2013)
Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
Mitsuyasu Kawaguchi et al.
ACS CHEMICAL BIOLOGY (2013)
Autotaxin inhibitors: a patent review
Efrosini Barbayianni et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2013)
Boron chemicals in diagnosis and therapeutics
Bhaskar C. Das et al.
FUTURE MEDICINAL CHEMISTRY (2013)
Why nature really chose phosphate
Shina C. L. Kamerlin et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2013)
Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Yong-Kang Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Borononucleotides as Substrates/Binders for Human NMP Kinases: Enzymatic and Spectroscopic Evaluation
Chahrazade El Amri et al.
CHEMBIOCHEM (2012)
Antiparasitic agents: new drugs on the horizon
Pascal Maeser et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
Yvonne R. Freund et al.
FEBS LETTERS (2012)
Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Yong-Kang Zhang et al.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2012)
Chalcone-Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents
Zhitao Qiao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery
Wei Bu et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2012)
Dynamic boronic acid-mediated autoligation of DNA strands
Michael Smietana et al.
PURE AND APPLIED CHEMISTRY (2012)
The use of phosphate bioisosteres in medicinal chemistry and chemical biology
Thomas S. Elliott et al.
MEDCHEMCOMM (2012)
Ring Structure and Aromatic Substituent Effects on the pKa of the Benzoxaborole Pharmacophore
John W. Tomsho et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Dynamic and Programmable DNA-Templated Boronic Ester Formation
Anthony R. Martin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents
Yong-Kang Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis
Robert T. Jacobs et al.
FUTURE MEDICINAL CHEMISTRY (2011)
Structure-Based Design of Novel Boronic Acid-Based Inhibitors of Autotaxin
Harald M. H. G. Abers et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Structural basis of substrate discrimination and integrin binding by autotaxin
Jens Hausmann et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Hiroshi Nishimasu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis
Robert T. Jacobs et al.
PLOS NEGLECTED TROPICAL DISEASES (2011)
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library
Rohan A. Davis et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application
Yong-Kang Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Discovery and Optimization of Boronic Acid Based Inhibitors of Autotaxin
Harald M. H. G. Albers et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation
Harald M. H. G. Albers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications
Paul C. Trippier et al.
MEDCHEMCOMM (2010)
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis
Tsutomu Akama et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Autotaxin
Jean A. Boutin et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Therapeutic potential of boron-containing compounds
Stephen J. Baker et al.
FUTURE MEDICINAL CHEMISTRY (2009)
Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression
Tobias Bopp et al.
JOURNAL OF IMMUNOLOGY (2009)
Benzoxaboroles - Old compounds with new applications
Agnieszka Adamczyk-Wozniak et al.
JOURNAL OF ORGANOMETALLIC CHEMISTRY (2009)
Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP
Anthony R. Martin et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2009)
Borononucleotides: synthesis, and formation of a new reversible boronate internucleosidic linkage
Delphine Luvino et al.
CHEMICAL COMMUNICATIONS (2008)
Boronic acids in molecular self-assembly
Norifumi Fujita et al.
CHEMISTRY-AN ASIAN JOURNAL (2008)
Prodrugs of phosphates and phosphonates
Scott J. Hecker et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Ternary borate-nucleoside complex stabilization by ribonuclease A demonstrates phosphate mimicry
Scott A. Gabel et al.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2008)
An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site
Fernando L. Rock et al.
SCIENCE (2007)
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
M Groll et al.
STRUCTURE (2006)
Phosphodiesterase-4 as a therapeutic target
MD Houslay et al.
DRUG DISCOVERY TODAY (2005)
The C-elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase
JD Kormish et al.
DEVELOPMENTAL BIOLOGY (2005)
Evidence that polyadenylation factor CPSF-73 is the rnRNA 3′ processing endonuclease
K Ryan et al.
RNA (2004)
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram
RX Xu et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Selecting protein tyrosine phosphatases as drug targets
RH van Huijsduijnen et al.
DRUG DISCOVERY TODAY (2002)
Share Paper
