Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume 26, Issue 26, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.202300340
Keywords
Gold; cancer; phototherapy; protein labeling; intracellular catalysis
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The medicinal chemistry of gold has seen rapid progress since the 2000s, with new modes of action emerging for gold-based drug candidates. Previously, the mechanisms of gold complexes were limited to direct coordination or supramolecular interactions, but recent research has revealed additional modalities such as photo-induced cytotoxicity, selective protein modification, and in cellulo catalysis.
The medicinal chemistry of gold has experienced an exponential development since the 2000s. For long, the mechanisms of action of gold complexes have been limited to direct coordination of the gold ion or supramolecular interactions of the whole gold complex with biomolecules. In the recent years, other modes of action of gold-based drug candidates have emerged. Herein, we review these new modalities, including photo-induced cytotoxicity, selective protein modification and in cellulo catalysis.
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