Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/eji.202250274
Keywords
Spinal cord injury; Inflammation; Lungs; Bone marrow; Liver; Bladder; Gut; Adipose tissue
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Spinal cord injury not only affects motor function, but also has systemic consequences on immune and metabolic functions. Therefore, studying the detrimental aspects of spinal cord injury is crucial for improving patients' lifespan and quality of life.
Spinal cord injury (SCI) affects hundreds of thousands of people in the United States, and while some effects of the injury are broadly recognized (deficits to locomotion, fine motor control, and quality of life), the systemic consequences of SCI are less well-known. The spinal cord regulates systemic immunological and visceral functions; this control is often disrupted by the injury, resulting in viscera including the gut, spleen, liver, bone marrow, and kidneys experiencing local tissue inflammation and physiological dysfunction. The extent of pathology depends on the injury level, severity, and time post-injury. In this review, we describe immunological and metabolic consequences of SCI across several organs. Since infection and metabolic disorders are primary reasons for reduced lifespan after SCI, it is imperative that research continues to focus on these deleterious aspects of SCI to improve life span and quality of life for individuals with SCI.
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