4.5 Review

State-of-the-art document on optimal contemporary management of cardiomyopathies

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Clinical characteristics and long-term outcomes in patients with peripartum cardiomyopathy (PPCM) receiving left ventricular assist devices (LVAD)

Dominik Berliner et al.

Summary: This study retrospectively analyzed the long-term outcomes of PPCM patients undergoing LVAD implantation in two tertiary centers. The results show that LVAD treatment of decompensated end-stage PPCM is feasible, and early LVAD provision can lead to safe LV recovery in young female patients.

ARTIFICIAL ORGANS (2023)

Review Cardiac & Cardiovascular Systems

Does a standard myectomy exist for obstructive hypertrophic cardiomyopathy? From the Morrow variations to precision surgery

Pierluigi Stefano et al.

Summary: This article reviews the history of surgical treatment for obstructive hypertrophic cardiomyopathy (oHCM) over the past 60 years, taking into account the advancing knowledge of the pathophysiology of obstruction. The contribution of different surgical approaches to the field is assessed based on personal experience in Florence. Septal myectomy is the preferred treatment for patients with obstructive hypertrophic cardiomyopathy who remain symptomatic despite optimal medical treatment.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2023)

Review Medicine, General & Internal

Diagnosis and Treatment of Acute Myocarditis A Review

Enrico Ammirati et al.

Summary: Acutemyocarditis is a sudden inflammatory injury to the myocardium, affecting around 4 to 14 people per 100 000 annually with a mortality rate of about 1% to 7%. The most common causes include viruses, autoimmune disorders, drugs, and vaccines. Symptoms include chest pain, dyspnea, and syncope. Diagnosis can be made through symptoms, biomarkers, electrocardiographic changes, and imaging/biopsy. Treatment depends on the severity, clinical presentation, and etiology.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)

Article Medicine, General & Internal

Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid

Pablo Garcia-Pavia et al.

Summary: NI006, a recombinant human anti-ATTR antibody, was found to be safe and effective in reducing the cardiac amyloid load in patients with ATTR cardiomyopathy and heart failure, according to a phase 1 trial.

NEW ENGLAND JOURNAL OF MEDICINE (2023)

Review Medicine, General & Internal

Immune Checkpoint Inhibitors-Related Myocarditis: A Review of Reported Clinical Cases

Liudmila Zotova

Summary: Myocarditis associated with the use of immune checkpoint inhibitors is a rare but potentially fatal side effect. Early detection of cardiotoxicity is crucial, as cardiac symptoms were present in nearly half of the reported cases. Further research and attention to the condition of the myocardium before and during treatment are needed.

DIAGNOSTICS (2023)

Article Cardiac & Cardiovascular Systems

Long-Term Survival With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy

Perry Elliott et al.

Summary: This study demonstrates the long-term efficacy of Tafamidis in the treatment of transthyretin amyloid cardiomyopathy, showing that patients who were initially treated with Tafamidis had significantly better survival rates than those who received placebo initially.

CIRCULATION-HEART FAILURE (2022)

Article Cardiac & Cardiovascular Systems

Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)

Rudolf A. de Boer et al.

Summary: This article discusses the pathogenesis, clinical presentation, and new medications and therapeutic approaches for genetic cardiomyopathies. With the use of contemporary research methods and tools, our understanding of cardiomyopathies has deepened, opening up new avenues for precision medicine.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC

Theresa A. McDonagh et al.

Summary: All experts involved in the development of the guidelines have declared their interests, and the declarations have been compiled and published in a supplementary report. The report can be accessed on the ESC website. The supplementary data provide background information and detailed discussion of the data that form the basis for the guidelines.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

Article Nutrition & Dietetics

An Emerging Role of Defective Copper Metabolism in Heart Disease

Yun Liu et al.

Summary: This paper summarizes the effects of defective copper homeostasis on heart disease and discusses potential underlying molecular mechanisms.

NUTRIENTS (2022)

Article Cardiac & Cardiovascular Systems

External validation of the HCM Risk-Kids model for predicting sudden cardiac death in childhood hypertrophic cardiomyopathy

Gabrielle Norrish et al.

Summary: This study conducted the first external validation of the HCM Risk-Kids model in a large and geographically diverse patient population. A 5-year predicted risk of >= 6% identified over 70% of events, confirming the model's ability to provide individualized risk predictions and shared decision-making in children with HCM.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Impella Mechanical Circulatory Support for Takotsubo SyndromeWith Shock: A Retrospective Multicenter Analysis

L. Christian Napp et al.

Summary: This study analyzed the characteristics and outcome of using Impella mechanical circulatory support for Takotsubo syndrome patients with cardiogenic shock. The study found that Impella pVAD was effective in supporting patients, reducing mortality, and promoting recovery of left ventricular systolic function. These results provide valuable guidance for the use of Impella treatment in this specific condition.

CARDIOVASCULAR REVASCULARIZATION MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Incidence and predictors of sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy: a pooled analysis

Thomas A. Agbaedeng et al.

Summary: This meta-analysis reveals a high burden of sudden cardiac death (SCD) in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Factors such as age, gender, right ventricular dysfunction, and electrocardiographic abnormalities are associated with an increased risk of SCD.

EUROPACE (2022)

Review Cardiac & Cardiovascular Systems

Electrical management of heart failure: from pathophysiology to treatment

Frits W. Prinzen et al.

Summary: Electrical disturbances are common in patients with heart failure and may contribute to its development and progression. Electrical treatment, such as rhythm control and cardiac resynchronization therapy, can reverse or alleviate heart failure. However, these therapies are currently underutilized and should be incorporated into the management of heart failure, considering individual patient characteristics.

EUROPEAN HEART JOURNAL (2022)

Review Medicine, General & Internal

Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond

Cristina Morelli et al.

Summary: The progress in science and technologies has allowed for the development of innovative drug molecules targeting the underlying pathophysiology of diseases. This has led to potential applications in heart muscle disease, heart failure, and skeletal muscle conditions. Several drugs, such as omecamtiv mecarbil, mavacamten, and aficamten, have shown promise in clinical trials, demonstrating efficacy in improving cardiac function and reducing heart failure-related events.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

Article Surgery

Clinical Outcomes and Survival of HIV Positive and Negative Patients on LVAD Support

S.E. Birk et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

Letter Cardiac & Cardiovascular Systems

Dynamic Ejection Fraction Trajectory in Patients With Dilated Cardiomyopathy With a Truncating Titin Variant

Michiel T. H. . M. Henkens et al.

CIRCULATION-HEART FAILURE (2022)

Review Cardiac & Cardiovascular Systems

Alcohol Intake in Patients With Cardiomyopathy and Heart Failure: Consensus and Controversy

Charlotte Andersson et al.

Summary: Alcohol is commonly considered a cause of cardiomyopathy and heart failure. However, recent studies have shown that moderate alcohol consumption may have beneficial effects on the cardiovascular system, lowering the risk of heart failure. Genetic epidemiological data do not support a causal link between alcohol consumption and heart failure risk, suggesting that alcohol may not be a common cause of heart failure in the community. The concept of alcoholic cardiomyopathy is mainly based on case series of patients with dilated cardiomyopathy who have a history of excessive alcohol intake. This state-of-the-art paper reviews the epidemiology of alcoholic cardiomyopathy and the role of alcohol intake in non-alcohol-related heart failure, while highlighting the need for further research.

CIRCULATION-HEART FAILURE (2022)

Article Cardiac & Cardiovascular Systems

Arrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator

Paloma Jorda et al.

Summary: This study validated a 5-year risk prediction model for ARVC patients, demonstrating its superior performance in guiding ICD implantation decisions compared to other published guidelines and consensus statements. The findings support the use of this model for shared decision making in the primary prevention of SCD in ARVC patients.

EUROPEAN HEART JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

Immunosuppressive therapy in virus-negative inflammatory cardiomyopathy: 20-year follow-up of the TIMIC trial

Cristina Chimenti et al.

Summary: Virus-negative inflammatory cardiomyopathy benefits from long-term immunosuppressive therapy, and recurrence can be controlled with a new TIMIC protocol treatment.

EUROPEAN HEART JOURNAL (2022)

Review Cardiac & Cardiovascular Systems

Implantable defibrillators in primary prevention of genetic arrhythmias. A shocking choice?

Domenico Corrado et al.

Summary: Many previously unexplained life-threatening ventricular arrhythmias and sudden cardiac deaths (SCDs) in young individuals are now recognized to be genetic in nature and are ascribed to a growing number of distinct inherited arrhythmogenic diseases. Risk assessment for SCD in patients with inherited arrhythmogenic diseases is challenging due to their lower frequency compared to coronary disease. Semi-automated systems are increasingly being used to dictate therapeutic choices, but their tendency to favour implantable cardioverter defibrillator (ICD) implantation may not always be justified.

EUROPEAN HEART JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator

Alexandros Protonotarios et al.

Summary: This study aims to investigate the influence of genotype on the performance of the 2019 risk model for ARVC. The results show that the ARVC risk model performs reasonably well in gene-positive ARVC patients, particularly for PKP2, but is more limited in gene-elusive patients. Genotype should be considered in future risk models for ARVC.

EUROPEAN HEART JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy

Milind Y. Desai et al.

Summary: This study found that mavacamten, an oral myosin inhibitor, significantly reduced the proportion of patients meeting guideline criteria for septal reduction therapy in patients with obstructive hypertrophic cardiomyopathy after 16 weeks.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Incidence of Sudden Cardiac Death and Life-Threatening Arrhythmias in Clinically Manifest Cardiac Sarcoidosis With and Without Current Indications for an Implantable Cardioverter Defibrillator

Hanna-Kaisa Nordenswan et al.

Summary: Current guidelines for ICD implantation in patients with clinically manifest CS do not effectively distinguish a truly low-risk group, as the 5-year risk of SCD approaches 5% even in the absence of ICD indications. Further research is needed to investigate prognostic factors, including the role of diagnostic histology. In the meantime, all patients with CS presenting with clinical cardiac manifestations should be considered for ICD implantation.

CIRCULATION (2022)

Article Cardiac & Cardiovascular Systems

Genetic Architecture of Acute Myocarditis and the Overlap With Inherited Cardiomyopathy

Amrit S. Lota et al.

Summary: The study investigated the frequency and clinical consequences of genetic variants associated with dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) in patients with acute myocarditis. The findings suggest that these genetic variants have clinical implications for treatment, risk stratification, and family screening in patients with acute myocarditis.

CIRCULATION (2022)

Review Cardiac & Cardiovascular Systems

Restrictive cardiomyopathy: definition and diagnosis

Claudio Rapezzi et al.

Summary: Restrictive cardiomyopathy is a heart disease characterized by restricted left ventricular pathophysiology, where there is a rapid rise in ventricular pressure but only small increases in filling volume due to increased myocardial stiffness. The phenotypic spectrum of restrictive cardiomyopathy is wide, with different disease mechanisms and presentations. Diagnosis is based on clinical data and various imaging techniques, and treatment options vary depending on the underlying cause of the disease.

EUROPEAN HEART JOURNAL (2022)

Article Cardiac & Cardiovascular Systems

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy

Luis Escobar-Lopez et al.

Summary: The Madrid Genotype Score is a useful tool for predicting the probability of a positive genetic test result in patients with DCM/LVSD, and it has been externally validated.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2022)

Review Cardiac & Cardiovascular Systems

Management of complications of cardiac amyloidosis: 10 questions and answers

Alberto Aimo et al.

Summary: Amyloidosis is a systemic disorder characterized by extracellular fibril deposition, with cardiac involvement being a common and significant manifestation leading to heart failure, atrial fibrillation, and conduction disturbances. Treatment for cardiac amyloidosis involves a combination of drug therapies, device implantation, and management of advanced heart failure.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

Article Biochemistry & Molecular Biology

Arterial thrombo-embolic events in cardiac amyloidosis: a look beyond atrial fibrillation

Francesco Cappelli et al.

Summary: In a large multicentric cohort of CA patients, the prevalence and incidence rate of AEs was high, with a significant proportion of events occurring despite anticoagulation therapy or in patients in sinus rhythm. A higher CHA2DS2-VASc score may identify patients at risk of AEs, even among those in sinus rhythm.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2021)

Review Cardiac & Cardiovascular Systems

2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease

Antonio Pelliccia et al.

EUROPEAN HEART JOURNAL (2021)

Article Multidisciplinary Sciences

Thiamine deficiency disorders: a clinical perspective

Taryn J. Smith et al.

Summary: Thiamine deficiency, a crucial issue affecting multiple systems, requires early diagnosis and treatment to prevent misdiagnosis and missed opportunities. Future research efforts should focus on determining effective treatment strategies for thiamine deficiency disorders.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2021)

Article Cardiac & Cardiovascular Systems

Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy A Multinational Collaboration

Julia Cadrin-Tourigny et al.

Summary: A simple prediction model using only 4 clinical predictors can predict LTVA events in patients with ARVC. Prior sustained VA and the extent of functional heart disease are not associated with subsequent LTVA events.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2021)

Review Biochemistry & Molecular Biology

Genetic Testing in Patients with Hypertrophic Cardiomyopathy

Jiri Bonaventura et al.

Summary: Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with complex genetic basis involving mutations in multiple genes. Patients without pathogenic variants are now believed to have non-Mendelian HCM and may have a better prognosis. Identifying the genetic basis of HCM provides opportunities for understanding disease development and potential interventions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Genetics & Heredity

Genetics of Peripartum Cardiomyopathy: Current Knowledge, Future Directions and Clinical Implications

Timothy F. Spracklen et al.

Summary: Peripartum cardiomyopathy (PPCM) is a condition characterized by heart failure and systolic dysfunction occurring late in pregnancy or within months following delivery. Approximately 20% of PPCM patients screened for cardiomyopathy genes have an identified pathogenic mutation, with TTN truncations being most commonly implicated. Molecular chaperones such as heat shock proteins may play a role in modulating PPCM pathogenesis.

GENES (2021)

Article Cardiac & Cardiovascular Systems

Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy

Sheila M. Hegde et al.

Summary: The BACKGROUND EXPLORER-HCM study showed that mavacamten can significantly improve left ventricular diastolic function and systolic anterior motion in patients with obstructive hypertrophic cardiomyopathy. Improvement in LVOT obstruction, LAVI, and E/e' was associated with reduction in a biomarker of myocardial wall stress.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy

Paaladinesh Thavendiranathan et al.

Summary: This study showed that GLS-guided cardioprotective therapy is effective in preventing reduction in LVEF and development of CTRCD in high-risk patients undergoing potentially cardiotoxic chemotherapy. Although the change in LVEF was not significantly different between the two arms as a whole, patients in the GLS-guided arm had significantly less reduction in LVEF at the 1-year follow-up.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Review Immunology

Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy

Emanuelle de Souza Santos et al.

Summary: Chagas disease caused by Trypanosoma cruzi can lead to Chronic Chagas cardiomyopathy (CCC) with severe complications like arrhythmias, heart failure, and death. Despite over a hundred years of discovery, there is still no effective treatment, especially for CCC. Immunomodulatory agents are considered a rational alternative due to the systemic inflammation causing cardiac tissue damage, showing potential in modulating inflammation and improving myocarditis in CCC models.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

From Systemic Inflammation to Myocardial Fibrosis The Heart Failure With Preserved Ejection Fraction Paradigm Revisited

Walter J. Paulus et al.

Summary: According to the comorbidity-inflammation paradigm, comorbidities, especially metabolic ones, are believed to drive the development and severity of heart failure with preserved ejection fraction. Recent evidence includes myocardial infiltration, inducible nitric oxide synthase expression, patient phenogroups, and direct connections between comorbidities, inflammatory biomarkers, and abnormal myocardial structure/function.

CIRCULATION RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Molecular Genetic Basis of Hypertrophic Cardiomyopathy

A. J. Marian

Summary: Hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by left ventricular hypertrophy and may lead to heart failure or sudden cardiac death. Pathogenic variants in genes encoding myocardial protein constituents, especially MYH7 and MYBPC3 genes, are the main causes of HCM. Advances in genetic testing and drug development have improved the therapeutic prospects for HCM.

CIRCULATION RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy: a European observational multicentre study

Antonio Creta et al.

Summary: Late AF relapses post-ablation are common in HCM patients, especially in those with persistent AF. Left atrium size, LV apical aneurysm, and the APPLE score might help identify subjects at higher risk of arrhythmia recurrence. The outcome of first-time cryoballoon ablation is comparable to radiofrequency ablation.

EUROPACE (2021)

Article Cardiac & Cardiovascular Systems

Diagnosis and treatment of cardiac amyloidosis. A position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Pablo Garcia-Pavia et al.

Summary: Cardiac amyloidosis is a serious and progressive infiltrative disease caused by the deposition of amyloid fibrils in the heart. With advances in imaging techniques and non-invasive diagnosis, it is now recognized as more common than traditionally believed. The Working Group on Myocardial and Pericardial Disease has proposed definitions, diagnostic algorithms, and treatment strategies to help bridge the gap between the latest research and clinical practice in managing cardiac amyloidosis.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy

Petar M. Seferovic et al.

Summary: Endomyocardial biopsy (EMB) is an invasive procedure commonly used for monitoring heart transplant rejection and diagnosing various cardiac disorders. Advances in EMB equipment and techniques have improved diagnostic precision. An expert consensus document provides a comprehensive overview on EMB, covering practical approaches, updated indications, revised surveillance plans, the impact of multimodality imaging, and current global clinical practices.

EUROPEAN JOURNAL OF HEART FAILURE (2021)

Article Cardiac & Cardiovascular Systems

International Evidence Based Reappraisal of Genes Associated With Arrhythmogenic Right Ventricular Cardiomyopathy Using the Clinical Genome Resource Framework

Cynthia A. James et al.

Summary: After a thorough review, only 8 genes have been definitively or moderately linked to ARVC, including PKP2, DSP, DSG2, DSC2, JUP, TMEM43, PLN, and DES. Pathogenic/likely pathogenic variants in these genes should be the main criteria for ARVC diagnosis, while variants in other genes require further investigation.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Prediction of ventricular arrhythmia in phospholamban p.Arg14del mutation carriers-reaching the frontiers of individual risk prediction

Tom E. Verstraelen et al.

Summary: This study aimed to develop a new mutation-specific prediction model for malignant VA in PLN p.Arg14del mutation carriers to improve risk stratification for primary prevention ICD implantation. The model outperformed the existing PLN risk model, indicating that using mutation-specific phenotypic features for risk prediction can enhance accuracy.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Peripartum cardiomyopathy: from genetics to management

Karen Sliwa et al.

Summary: Peripartum cardiomyopathy is a global disease that should be suspected in peripartum women with symptoms of heart failure. Urgent cardiac investigations and referral to a cardiology team for expert management are crucial. Advances in genetics, pathophysiology, diagnostic approach, management, and outcome have been achieved in understanding PPCM.

EUROPEAN HEART JOURNAL (2021)

Editorial Material Cardiac & Cardiovascular Systems

Arrhythmic risk stratification in arrhythmogenic cardiomyopathy: new predictors for left-sided variants?

Domenico Corrado et al.

EUROPEAN HEART JOURNAL (2021)

Article Medicine, General & Internal

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

Julian D. Gillmore et al.

Summary: The gene-editing therapeutic agent NTLA-2001 effectively reduced serum TTR protein concentrations in patients with ATTR amyloidosis, showing potential safety and pharmacodynamic effects in clinical studies.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Letter Cardiac & Cardiovascular Systems

Levosimendan improves the acute course of takotsubo syndrome: a pooled analysis

Milosz J. Jaguszewski et al.

ESC HEART FAILURE (2021)

Review Cardiac & Cardiovascular Systems

Effect of Acute Immunosuppression on Left Ventricular Recovery and Mortality in Fulminant Viral Myocarditis: A Case Series and Review of Literature

Pierre Yves Turgeon et al.

Summary: Fulminant viral myocarditis is a rare cause of cardiogenic shock with high morbidity and mortality rates. Acute immunosuppressive therapy has gained popularity as a treatment method. Studies have evaluated its effectiveness through literature review and retrospective analysis of cases.

CJC OPEN (2021)

Article Cardiac & Cardiovascular Systems

Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy

Milind Y. Desai et al.

Summary: In patients with intractable symptoms of oHCM, mavacamten significantly reduced the proportion of patients meeting guideline criteria for SRT after 16 weeks.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Prediction of ventricular arrhythmia in phospholamban p.Arg14del mutation carriers-reaching the frontiers of individual risk prediction

Tom E. Verstraelen et al.

Summary: This study aimed to develop a new mutation-specific prediction model for malignant ventricular arrhythmia (VA) in phospholamban (PLN) p.Arg14del mutation carriers, and compared it to an existing PLN risk model. The new model demonstrated superior accuracy in predicting individual VA risk compared to the existing model.

EUROPEAN HEART JOURNAL (2021)

Review Cardiac & Cardiovascular Systems

Peripartum cardiomyopathy: from genetics to management

Karen Sliwa et al.

Summary: Peripartum cardiomyopathy is a globally occurring disease that should be suspected in women during the peripartum period. The disease has significant maternal and neonatal morbidity and mortality rates, with nearly half of patients experiencing myocardial recovery. Team efforts and expert management are crucial in the diagnosis and treatment of this condition.

EUROPEAN HEART JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Cardiac Sarcoidosis multi-center randomized controlled trial (CHASM CS- RCT)

David Birnie et al.

AMERICAN HEART JOURNAL (2020)

Review Cardiac & Cardiovascular Systems

Peripartum cardiomyopathy: basic mechanisms and hope for new therapies

Melanie Ricke-Hoch et al.

CARDIOVASCULAR RESEARCH (2020)

Article Cardiac & Cardiovascular Systems

Classification, prevalence, and outcomes of anticancer therapy-induced cardiotoxicity: the CARDIOTOX registry

Jose Lopez-Sendon et al.

EUROPEAN HEART JOURNAL (2020)

Review Cardiac & Cardiovascular Systems

Heart failure can affect everyone: the ESC Geoffrey Rose lecture

Karen Sliwa

EUROPEAN HEART JOURNAL (2020)

Review Hematology

Diagnosis and management of hereditary haemochromatosis

Catherine R. Murphree et al.

VOX SANGUINIS (2020)

Article Cardiac & Cardiovascular Systems

Effectiveness of sacubitril-valsartan in cancer patients with heart failure

Ana Martin-Garcia et al.

ESC HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Hypertrophic Cardiomyopathy With Left Ventricular Systolic Dysfunction Insights From the SHaRe Registry

Peter Marstrand et al.

CIRCULATION (2020)

Article Cardiac & Cardiovascular Systems

Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy

Marco Merlo et al.

EUROPEAN JOURNAL OF HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association

Michelle M. Kittleson et al.

CIRCULATION (2020)

Article Cardiac & Cardiovascular Systems

Diagnosis of arrhythmogenic cardiomyopathy: The Padua criteria

Domenico Corrado et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Clinical presentation, management, and 6-month outcomes in women with peripartum cardiomyopathy: an ESC EORP registry

Karen Sliwa et al.

EUROPEAN HEART JOURNAL (2020)

Review Cardiac & Cardiovascular Systems

Challenges in Cardiac and Pulmonary Sarcoidosis JACC State-of-the-Art Review

Maria Giovanna Trivieri et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy

Steve R. Ommen et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy An Expert Consensus Document

Enrico Ammirati et al.

CIRCULATION-HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

Cardiogenic shock complicating peripartum cardiomyopathy: Importance of early left ventricular unloading and bromocriptine therapy

Jan-Thorben Sieweke et al.

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE (2020)

Article Cardiac & Cardiovascular Systems

Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis

Domenico Corrado et al.

EUROPEAN HEART JOURNAL (2020)

Article Cardiac & Cardiovascular Systems

A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Julia Cadrin-Tourigny et al.

EUROPEAN HEART JOURNAL (2019)

Review Endocrinology & Metabolism

The effectiveness of enzyme replacement therapy for juvenile-onset Pompe disease: A systematic review

Milverton Joanne et al.

JOURNAL OF INHERITED METABOLIC DISEASE (2019)

Article Cardiac & Cardiovascular Systems

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology

Petar M. Seferovic et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Review Cardiac & Cardiovascular Systems

Arrhythmia-Induced Cardiomyopathy JACC State-of-the-Art Review

Jose F. Huizar et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Letter Medicine, General & Internal

Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy

Khashayar Esfahani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Letter Medicine, General & Internal

Abatacept for Severe Immune Checkpoint Inhibitor-Associated Myocarditis

Joe-Elie Salem et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Cardiac & Cardiovascular Systems

Role of Targeted Therapy in Dilated Cardiomyopathy: The Challenging Road Toward a Personalized Approach

Job A. J. Verdonschot et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

Letter Cardiac & Cardiovascular Systems

Immunosuppression in inflammatory cardiomyopathy and parvovirus B19 persistence

Carsten Tschoepe et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

Letter Cardiac & Cardiovascular Systems

No Association Between CHADS-VASc Score and Left Atrial Appendage Thrombus in Patients With Transthyretin Amyloidosis

Eoin Donnellan et al.

JACC-CLINICAL ELECTROPHYSIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-termlife-threatening arrhythmias

Job A. J. Verdonschot et al.

EUROPEAN HEART JOURNAL (2018)

Article Cardiac & Cardiovascular Systems

International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management

Jelena-Rima Ghadri et al.

EUROPEAN HEART JOURNAL (2018)

Review Cardiac & Cardiovascular Systems

Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis

Rajiv Mahajan et al.

EUROPEAN HEART JOURNAL (2018)

Editorial Material Cardiac & Cardiovascular Systems

Anthracycline-induced cardiomyopathy: secrets and lies

Dimitrios Farmakis et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

Article Cardiac & Cardiovascular Systems

Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology

Maria G. Crespo-Leiro et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

Review Immunology

Imatinib for the treatment of hypereosinophilic syndromes

Grzegorz Helbig

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Spectrum of Restrictive and Infiltrative Cardiomyopathies Part 2 of a 2-Part Series

Naveen L. Pereira et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Spectrum of Restrictive and Infiltrative Cardiomyopathies Part 1 of a 2-Part Series

Naveen L. Pereira et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Review Endocrinology & Metabolism

Fabry disease revisited: Management and treatment recommendations for adult patients

Alberto Ortiz et al.

MOLECULAR GENETICS AND METABOLISM (2018)

Article Medicine, General & Internal

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

D. Adams et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

M. D. Benson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Catheter Ablation for Atrial Fibrillation with Heart Failure

Nassir F. Marrouche et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition

Lorena Saelices et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Cardiac & Cardiovascular Systems

Genetic Infiltrative Cardiomyopathies

Mary E. Sweet et al.

HEART FAILURE CLINICS (2018)

Article Cardiac & Cardiovascular Systems

2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy

Vera Regitz-Zagrosek et al.

EUROPEAN HEART JOURNAL (2018)

Article Medicine, General & Internal

Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy

Mathew S. Maurer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Immunology

Reactivation of Chagas disease among heart transplant recipients in the United States, 2012-2016

Elizabeth B. Gray et al.

TRANSPLANT INFECTIOUS DISEASE (2018)

Review Physiology

Role of Lamin A/C Gene Mutations in the Signaling Defects Leading to Cardiomyopathies

Andrea Gerbino et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Clinical Phenotype and Genotype Associations With Improvement in Left Ventricular Function in Dilated Cardiomyopathy

Job A. J. Verdonschot et al.

CIRCULATION-HEART FAILURE (2018)

Article Genetics & Heredity

Utility of genetics for risk stratification in pediatric hypertrophic cardiomyopathy

J. Mathew et al.

CLINICAL GENETICS (2018)

Article Medicine, General & Internal

Severe Course of Peripartum Cardiomyopathy and Subsequent Recovery in a Patient with a Novel TTN Gene-Truncating Mutation

Karolina E. Kryczka et al.

AMERICAN JOURNAL OF CASE REPORTS (2018)

Article Cardiac & Cardiovascular Systems

Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy

Britta Stapel et al.

EUROPEAN HEART JOURNAL (2017)

Article Cardiac & Cardiovascular Systems

Bromocriptine for the treatment of peripartum cardiomyopathy: a multicentre randomized study

Denise Hilfiker-Kleiner et al.

EUROPEAN HEART JOURNAL (2017)

Article Cardiac & Cardiovascular Systems

Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies

Shahrzad Sepehrkhouy et al.

HEART RHYTHM (2017)

Article Cardiac & Cardiovascular Systems

Impact of early initiation of corticosteroid therapy on cardiac function and rhythm in patients with cardiac sarcoidosis

Santosh K. Padala et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Outcomes of Restrictive and Hypertrophic Cardiomyopathies After LVAD: An INTERMACS Analysis

Snehal R. Patel et al.

JOURNAL OF CARDIAC FAILURE (2017)

Article Cardiac & Cardiovascular Systems

Eosinophilic Myocarditis Characteristics, Treatment, and Outcomes

Michela Brambatti et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Review Cardiac & Cardiovascular Systems

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

Gavin A. Lewis et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

Review Medicine, General & Internal

Arrhythmogenic Right Ventricular Cardiomyopathy

Domenico Corrado et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy

Hugh Calkins et al.

CIRCULATION (2017)

Article Cardiac & Cardiovascular Systems

Arrhythmogenic Cardiomyopathy

Domenico Corrado et al.

CIRCULATION RESEARCH (2017)

Article Cardiac & Cardiovascular Systems

Surgical treatment for hypertrophic cardiomyopathy: a historical perspective

Dustin Hang et al.

ANNALS OF CARDIOTHORACIC SURGERY (2017)

Article Cardiac & Cardiovascular Systems

Value of Genetic Testing for the Prediction of Long-Term Outcome in Patients With Hypertrophic Cardiomyopathy

Hannah G. van Velzen et al.

AMERICAN JOURNAL OF CARDIOLOGY (2016)

Article Pharmacology & Pharmacy

Left Ventricular Dysfunction After Treatment With Ipilimumab for Metastatic Melanoma

Mary E. Roth et al.

AMERICAN JOURNAL OF THERAPEUTICS (2016)

Article Cardiac & Cardiovascular Systems

Arrhythmogenic Right Ventricular Cardiomyopathy Clinical Course and Predictors of Arrhythmic Risk

Andrea Mazzanti et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

AL (Light-Chain) Cardiac Amyloidosis A Review of Diagnosis and Therapy

Rodney H. Falk et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

Article Medicine, General & Internal

Treatment of Fabry's Disease with the Pharmacologic Chaperone Migalastat

D. P. Germain et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Cardiac & Cardiovascular Systems

Arrhythmogenic Cardiomyopathy: Electrical and Structural Phenotypes

Deniz Akdis et al.

ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW (2016)

Article Cardiac & Cardiovascular Systems

Cardiogenic Shock in Takotsubo Cardiomyopathy: A Focus on Management

Katie M. Doucet et al.

CANADIAN JOURNAL OF CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy

Daniela Cardinale et al.

CIRCULATION (2015)

Article Cardiac & Cardiovascular Systems

Treatment of arrhythmogenic right ventricular cardiomyopathy/dysplasia: an international task force consensus statement

Domenico Corrado et al.

EUROPEAN HEART JOURNAL (2015)

Article Cardiac & Cardiovascular Systems

Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction

Esther Gonzalez-Lopez et al.

EUROPEAN HEART JOURNAL (2015)

Article Cardiac & Cardiovascular Systems

Prediction of thrombo-embolic risk in patients with hypertrophic cardiomyopathy (HCM Risk-CVA)

Oliver P. Guttmann et al.

EUROPEAN JOURNAL OF HEART FAILURE (2015)

Article Cardiac & Cardiovascular Systems

Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomyopathy Applying the MOGE(S) Classification

Mark R. Hazebroek et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Article Medicine, General & Internal

Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy

C. A. Morillo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

C. Templin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component

Duncan B. Richards et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Cardiac & Cardiovascular Systems

Natural History and Prognostic Factors in Alcoholic Cardiomyopathy

Gonzalo Guzzo-Merello et al.

JACC-HEART FAILURE (2015)

Article Cardiac & Cardiovascular Systems

Cardiac Sarcoidosis Epidemiology, Characteristics, and Outcome Over 25 Years in a Nationwide Study

Riina Kandolin et al.

CIRCULATION (2015)

Article Cardiac & Cardiovascular Systems

Different Prognostic Value of Functional Right Ventricular Parameters in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Ardan M. Saguner et al.

CIRCULATION-CARDIOVASCULAR IMAGING (2014)

Review Cardiac & Cardiovascular Systems

Risk of Subsequent Pregnancy in Women With a History of Peripartum Cardiomyopathy

Uri Elkayam

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Review Cardiac & Cardiovascular Systems

Chagas Disease An Overview of Clinical and Epidemiological Aspects

Maria Carmo Pereira Nunes et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

Roberto Spoladore et al.

EUROPEAN HEART JOURNAL (2012)

Article Cardiac & Cardiovascular Systems

Risk Factors for Malignant Ventricular Arrhythmias in Lamin A/C Mutation Carriers A European Cohort Study

Ingrid A. W. van Rijsingen et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2012)

Article Hematology

Treatment of Hypereosinophilic Syndromes-The First 100 Years

J. H. Butterfield et al.

SEMINARS IN HEMATOLOGY (2012)

Letter Cardiac & Cardiovascular Systems

Heart transplantation in HIV-infected patients: More cases in Europe

Maria Angeles Castel et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2011)

Article Cardiac & Cardiovascular Systems

Relationship between burden of premature ventricular complexes and left ventricular function

Timir S. Baman et al.

HEART RHYTHM (2010)

Article Psychology, Clinical

Diagnostic Characteristics of Clozapine-Induced Myocarditis Identified by an Analysis of 38 Cases and 47 Controls

Kathlyn J. Ronaldson et al.

JOURNAL OF CLINICAL PSYCHIATRY (2010)

Article Cardiac & Cardiovascular Systems

Anthracycline-Induced Cardiomyopathy Clinical Relevance and Response to Pharmacologic Therapy

Daniela Cardinale et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Detection of Myocardial Damage in Patients With Sarcoidosis

Manesh R. Patel et al.

CIRCULATION (2009)

Article Cardiac & Cardiovascular Systems

Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy

Katharine M. Brauch et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Usefulness of Immunosuppression for Giant Cell Myocarditis

Leslie T. Cooper et al.

AMERICAN JOURNAL OF CARDIOLOGY (2008)

Article Cardiac & Cardiovascular Systems

Clinical characteristics, treatment; and outcome of tachycardia induced cardiomyopathy

Hiroshi Watanabe et al.

INTERNATIONAL HEART JOURNAL (2008)

Review Cardiac & Cardiovascular Systems

Pathogenesis of chronic Chagas heart disease

Jose Antonio Marin-Neto et al.

CIRCULATION (2007)

Article Cardiac & Cardiovascular Systems

Cardiomyopathy related to antimalarial therapy with illustrative case report

Nathalie Costedoat-Chalumeau et al.

CARDIOLOGY (2007)

Article Clinical Neurology

Cardiomyopathy after long-term treatment with lithium - more than a coincidence?

W. Aichhorn et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2006)

Article Critical Care Medicine

Clinical characteristics of patients in a case control study of sarcoidosis

RP Baughman et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

Review Cardiac & Cardiovascular Systems

Cardiomyopathy in AIDS: A pathophysiological perspective

W Lewis

PROGRESS IN CARDIOVASCULAR DISEASES (2000)