Pathogenic pathways and therapeutic targets of inflammation in heart diseases: A focus on Interleukin-1

Letter Cardiac & Cardiovascular Systems

Interleukin-1 Blockade in Cardiac Sarcoidosis: A Pilot Study

Jordana Kron et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2023)

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Letter Medicine, General & Internal

Incidence of myocarditis and pericarditis considered as separate clinical events over the years and post-SARS-CoV2 vaccination in adults and children

Edoardo Conte et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2023)

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Review Medicine, General & Internal

Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy

Daniel Harding et al.

Summary: Dilated cardiomyopathy is a heart disease with unknown causes and limited treatment options. Immune dysfunction is believed to play a significant role in its development and progression. Current treatment focuses on symptom management and reducing the risk of sudden cardiac death.

JOURNAL OF INTERNAL MEDICINE (2023)

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Article Cardiac & Cardiovascular Systems

SARS-COV-2 AND MRNA VACCINE-ASSOCIATED RECURRENT PERICARDITIS TREATED WITH RILONACEPT

John Clark Shell et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

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Editorial Material Cardiac & Cardiovascular Systems

Colchicine for cardiovascular prevention: the dawn of a new era has finally come

Aldo Bonaventura et al.

EUROPEAN HEART JOURNAL (2023)

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Review Cardiac & Cardiovascular Systems

Immune checkpoint inhibitor-associated myocarditis: from pathophysiology to rechallenge of therapy - a narrative review

Andrea Tedeschi et al.

Summary: Although immune checkpoint inhibitors have greatly improved cancer therapy, they can lead to immune-related adverse events, with myocarditis being the most severe complication. Clinical suspicion arises from symptoms and increases in cardiac biomarkers or electrocardiographic manifestations. While echocardiography and cardiac magnetic resonance imaging are recommended, endomyocardial biopsy remains the gold standard for diagnosis. Treatment currently relies on glucocorticoids, but interest in other immunosuppressive agents is growing. Some case reports suggest the safety of rechallenging low-grade myocarditis, highlighting the need for further studies in this area.

FUTURE CARDIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Treatment of Idiopathic Recurrent Pericarditis With Goflikicept Phase II/III Study Results

Valentina Yu. Myachikova et al.

Summary: This study evaluated the efficacy and safety of goflikicept, a new IL-1 inhibitor, in patients with idiopathic recurrent pericarditis. The results demonstrated that goflikicept treatment significantly reduced the risk of pericarditis recurrence compared to placebo, with no new safety concerns identified.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2023)

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Article Cardiac & Cardiovascular Systems

Rationale and design of the ARAMIS trial: Anakinra versus placebo, a double blind randomized controlled trial for the treatment of acute myocarditis

Mathieu Kerneis et al.

Summary: The ARAMIS trial aims to test the impact of inhibiting the interleukin-1 beta immune innate pathway on the clinical events risk in acute myocarditis. This trial will be the largest randomized trial in acute myocarditis, shedding light on this serious yet poorly studied cardiac condition.

ARCHIVES OF CARDIOVASCULAR DISEASES (2023)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 blockade with anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical trials

Antonio Abbate et al.

Summary: This study suggests that treatment with Anakinra for 14 days can lower the incidence of new-onset HF or hospitalization for HF in patients with STEMI.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2022)

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Article Cardiac & Cardiovascular Systems

Prevalence, Characteristics, and Outcomes of COVID-19-Associated Acute Myocarditis

Enrico Ammirati et al.

Summary: The prevalence of acute myocarditis (AM) in COVID-19 patients is estimated to be between 2.4 and 4.1 per 1000 hospitalized patients. Most cases of AM occur in the absence of pneumonia and are often complicated by hemodynamic instability.

CIRCULATION (2022)

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Review Critical Care Medicine

Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination: a systematic review and meta-analysis

Ryan Ruiyang Ling et al.

Summary: The overall risk of myopericarditis after receiving a COVID-19 vaccine is low, but younger males have an increased incidence of myopericarditis, especially after receiving mRNA vaccines. However, the risks of such rare adverse events should be balanced against the risks of COVID-19 infection (including myopericarditis).

LANCET RESPIRATORY MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

COVID-19 Vaccine-Related Myocardial and Pericardial Inflammation

Muhammad Furqan et al.

Summary: This review examines myocarditis and pericarditis cases following COVID-19 vaccinations and provides management strategies. The study concludes that COVID-19 mRNA vaccines are safe and effective with mild and transient side effects. The incidence of myocarditis/pericarditis after vaccination is extremely low compared to COVID-19 infection. Vaccine-related inflammatory heart conditions are usually temporary. Treatment includes non-steroidal anti-inflammatory drugs and colchicine, with corticosteroids reserved for refractory cases. Athletes diagnosed with vaccine-related myocarditis are advised to abstain from exercise for at least 3-6 months.

CURRENT CARDIOLOGY REPORTS (2022)

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Editorial Material Medicine, General & Internal

Myocarditis

Cristina Basso

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Letter Medicine, General & Internal

IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

[Anonymous]

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

Systematic Review/Meta-analysis Colchicine for Secondary Prevention of Cardiovascular Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Michelle Samuel et al.

Summary: Low-dose colchicine has shown significant efficacy in reducing cardiovascular events among patients with coronary artery disease in randomized controlled trials, particularly in reducing the incidence of myocardial infarction, ischemic stroke, and urgent coronary revascularizations. Safety outcomes did not differ significantly between groups.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Clinical and Imaging Response to Tumor Necrosis Factor Alpha Inhibitors in Treatment of Cardiac Sarcoidosis: A Multicenter Experience

Nisha A. Gilotra et al.

Summary: TNF alpha inhibitor treatment guided by FDG-PET imaging may reduce corticosteroid use and effectively decrease cardiac inflammation without significant adverse effect on cardiac function. However, infections were common, some of which were serious, and therefore patients require close monitoring for both infection and cardiac symptoms.

JOURNAL OF CARDIAC FAILURE (2021)

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Review Cardiac & Cardiovascular Systems

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

Carsten Tschoepe et al.

Summary: Inflammatory cardiomyopathy is a disease characterized by inflammatory cell infiltration into the myocardium and is predominantly mediated by viral infection. Despite extensive research, inflammatory cardiomyopathy complicated by left ventricular dysfunction, heart failure or arrhythmia is associated with a poor prognosis. The relative roles of the pathogen, host genomics and environmental factors in disease progression and healing are still under discussion.

NATURE REVIEWS CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Pericarditis Recurrence After Initial Uncomplicated Clinical Course

Marco Giuseppe Del Buono et al.

Summary: This study evaluated the incidence and clinical predictors of recurrence after a first episode of acute uncomplicated pericarditis in a large urban hospital in the United States. The findings showed that 9% of patients experienced recurrence over a 6-month median follow-up, with younger age and subacute presentation being significantly associated with an increased risk of recurrence.

AMERICAN JOURNAL OF CARDIOLOGY (2021)

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Review Medicine, General & Internal

Effect of low-dose colchicine in acute and chronic coronary syndromes: A systematic review and meta-analysis

Alberto Aimo et al.

Summary: Colchicine therapy significantly reduced the risk of cardiovascular events in CCS patients compared to placebo, and showed a trend towards reducing the risk in ACS patients as well. Additionally, colchicine tended to reduce the increase of hs-CRP levels compared to placebo.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Cardiac & Cardiovascular Systems

Efficacy and safety of rilonacept for recurrent pericarditis: results from a phase II clinical trial

Allan L. Klein et al.

Summary: Rilonacept demonstrated rapid and sustained improvement in pain and inflammation in recurrent pericarditis, successfully tapering or discontinuing corticosteroids with a safety profile consistent with known data.

HEART (2021)

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Article Cardiac & Cardiovascular Systems

Anti-interleukin 1 agents for the treatment of recurrent pericarditis

M Imazio et al.

EUROPEAN HEART JOURNAL (2021)

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Article Medicine, General & Internal

Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

Allan L. Klein et al.

Summary: Rilonacept leads to rapid resolution of recurrent pericarditis episodes and significantly lower risk of pericarditis recurrence compared to placebo among patients with recurrent pericarditis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Clinical outcomes of patients with isolated cardiac sarcoidosis confirmed by clinical diagnostic criteria

Yoichi Takaya et al.

Summary: Patients with isolated CS exhibit clinical features similar to those with systemic CS, but have a higher rate of cardiac events.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients

Antonio Abbate et al.

Summary: Immune-mediated myocardial injury can occur in both adults and children following infection with SARS-CoV2. Recent cases have shown myocarditis following immunization for SARS-CoV2, with most cases being mild and showing spontaneous recovery.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Medicine, Research & Experimental

Interleukin-1 blockade in cardiac sarcoidosis: study design of the multimodality assessment of granulomas in cardiac sarcoidosis: Anakinra Randomized Trial (MAGiC-ART)

Jordana Kron et al.

Summary: Cardiac sarcoidosis is a rare disease that can lead to life-threatening complications, and this trial aims to investigate the effectiveness of IL-1 blockade with anakinra in combating systemic and cardiac inflammation in patients with this condition.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Arrhythmias in Cardiac Sarcoidosis Bench to Bedside A Case-Based Review

Lynda E. Rosenfeld et al.

Summary: Cardiac sarcoidosis, a component of a multiorgan granulomatous disease, is being increasingly recognized due to heightened awareness and new diagnostic tests like cardiac magnetic resonance imaging and F-18-fluorodeoxyglucose positron emission tomography scans. Early diagnosis using these tools is crucial for potentially life-saving measures, and treatment options including those related to heart failure and disease mechanisms play an important role in patient care.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2021)

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Review Medicine, Research & Experimental

Immune checkpoint inhibitor-associated myocarditis: manifestations arms mechanisms

Javid Moslehi et al.

Summary: Immune checkpoint inhibitors have revolutionized the treatment of cancer, but associated toxicities like myocarditis pose challenges that require further research, predictive biomarker identification, and improved diagnostic and treatment strategies.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Medicine, General & Internal

An update on the pathophysiology of acute and recurrent pericarditis

Aldo Bonaventura et al.

Summary: Recent progress has been made in understanding the pathophysiology of pericarditis. Studies have shown the role of interleukin (IL)-1 and NLRP3 inflammasome in the inflammatory reaction to various stimuli, with viral infections being a common cause. This knowledge could potentially lead to targeted therapies in the future.

PANMINERVA MEDICA (2021)

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Article Cardiac & Cardiovascular Systems

Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure

Dongze Zhang et al.

Summary: Macrophage depletion in the stellate ganglion can reduce cardiac sympathetic overactivation and ventricular arrhythmias in patients with chronic heart failure. The study found that reducing macrophage expansion and neuroinflammation can effectively inhibit cardiac sympathetic overexcitation and ventricular arrhythmias.

BASIC RESEARCH IN CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Emerging Therapies for Recurrent Pericarditis: Interleukin-1 inhibitors

Saberio Lo Presti et al.

Summary: Recurrent pericarditis (RP) is a complex inflammatory disorder with unknown etiology, but IL-1 inhibitors have emerged as a treatment option with beneficial clinical outcomes.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Review Cardiac & Cardiovascular Systems

Interleukin-1 and the NLRP3 Inflammasome in Pericardial Disease

Alessandra Vecchie et al.

Summary: Pericarditis is generally a benign disease, but complications and/or recurrences may occur in up to 30% of cases. Recent evidence suggests that the activation of the NLRP3 inflammasome is central in the pathophysiology of pericarditis. Colchicine and IL-1-targeted therapies have been found to effectively reduce acute inflammation and decrease the risk of recurrences.

CURRENT CARDIOLOGY REPORTS (2021)

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Review Cardiac & Cardiovascular Systems

Colchicine and the heart

Massimo Imazio et al.

Summary: Colchicine, a unique anti-inflammatory agent, has shown potential in a range of cardiovascular conditions in recent clinical trials, in addition to its traditional use in gout and familial Mediterranean fever.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction

Kaspar Broch et al.

Summary: The study showed that tocilizumab, an interleukin-6 receptor inhibitor, increased myocardial salvage in patients with acute STEMI, reduced microvascular obstruction, but did not significantly decrease final infarct size.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Targeting inflammation in atherosclerosis - from experimental insights to the clinic

Oliver Soehnlein et al.

Summary: Inflammation plays a substantial role in atherosclerosis and targeting inflammatory pathways could provide a promising new avenue to prevent and treat the disease. Clinical studies have shown that modulation of inflammation can help prevent the clinical complications of atherosclerosis. Refining strategies for combatting inflammation in the disease is crucial for further progress in managing atherosclerotic risk.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Cell Biology

Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond

Peter Libby

Summary: Inflammation plays a causal role in human atherosclerosis, and recent clinical trials point towards potential novel treatments. This review evaluates the current state of anti-inflammatory interventions, focusing on innate immunity and utilizing biomarkers to guide therapy allocation. The validation of decades of research in recent clinical investigations provides a strong motivation for further efforts to target inflammation in atherosclerosis.

CELLS (2021)

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Article Cardiac & Cardiovascular Systems

Perimyocarditis following first dose of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine in a healthy young male: a case report

Ammar A. Hasnie et al.

Summary: The case report describes a 22-year-old Caucasian male who developed perimyocarditis after receiving the Moderna vaccine, emphasizing the importance for clinicians to be aware of this rare but significant adverse event.

BMC CARDIOVASCULAR DISORDERS (2021)

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Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With the special contribution of the European Association of Preventive Cardiology (EAPC)

Frank L. J. Visseren et al.

EUROPEAN HEART JOURNAL (2021)

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Article Medicine, General & Internal

Prevalence and clinical outcomes of myocarditis and pericarditis in 718,365 COVID-19 patients

Benjamin J. R. Buckley et al.

Summary: This study found that patients with COVID-19 who develop myocarditis/pericarditis have an increased risk of major adverse events and new-onset cardiovascular sequelae.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Letter Medicine, General & Internal

Myocarditis and Pericarditis After Vaccination for COVID-19

George A. Diaz et al.

Summary: This study compares the incidence of myocarditis and pericarditis in emergency department or inpatient hospital encounters before and during the period of COVID-19 vaccination availability in a large US health care system.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Letter Cardiac & Cardiovascular Systems

Clarification Regarding the Lack of Heart Failure Events in the ASSAIL-MI Trial

Marco Giuseppe Del Buono et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Corticosteroid and Immunosuppressant Therapy for Cardiac Sarcoidosis: A Systematic Review

Siavosh Fazelpour et al.

Summary: The best quality data relate to atrioventricular nodal conduction and left ventricular function recovery. In both situations, therapy with corticosteroids and/or immunosuppressant therapy were sometimes associated with positive outcomes. The data quality is too limited to draw conclusions for ventricular arrhythmias and mortality.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Review Biochemistry & Molecular Biology

The signal pathways and treatment of cytokine storm in COVID-19

Lan Yang et al.

Summary: The COVID-19 pandemic is a global crisis with devastating effects, where immunopathology plays a crucial role in disease progression, particularly the cytokine storm which has a significant impact on prognosis. Understanding and targeting the pathways involved in cytokine storm could lead to more effective treatment strategies for COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Cardiac & Cardiovascular Systems

The Role of NLRP3 Inflammasome in Pericarditis

Adolfo G. Mauro et al.

Summary: In patients with chronic pericarditis and a mouse model of pericarditis, an intensification of inflammasome activation was observed, along with the demonstration of pathological features of pericarditis. NLRP3 inflammasome inhibitor, anakinra, and interleukin-1 trap showed significant improvement in pericardial alterations, while colchicine partially improved pericardial inflammation, highlighting the role of inflammasome in both human and mouse models of pericarditis.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)

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Article Cardiac & Cardiovascular Systems

Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II-III Systolic Heart Failure

George F. Wohlford et al.

Summary: This study investigated the safety of an oral inhibitor of the NLRP3 inflammasome, dapansutrile, in patients with heart failure and reduced ejection fraction. The results showed that treatment with dapansutrile for 14 days was safe and well tolerated in stable patients with heart failure and reduced ejection fraction, with some improvements in left ventricular ejection fraction and exercise time observed in the high-dose cohort.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Cardiac Sarcoidosis multi-center randomized controlled trial (CHASM CS- RCT)

David Birnie et al.

AMERICAN HEART JOURNAL (2020)

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Article Immunology

IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis

M. Abe et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

Antonio Abbate et al.

CIRCULATION RESEARCH (2020)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 Blockade Inhibits the Acute Inflammatory Response in Patients With ST-Segment-Elevation Myocardial Infarction

Antonio Abbate et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Cardiac & Cardiovascular Systems

Cardiovascular Considerations in Treating Patients With Coronavirus Disease 2019 (COVID-19)

Dave L. Dixon et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Acute Effects of Interleukin-1 Blockade Using Anakinra in Patients With Acute Pericarditis

George F. Wohlford et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

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Article Critical Care Medicine

Clinical Presentation and Outcomes of Acute Pericarditis in a Large Urban Hospital in the United States of America

Alessandra Vecchie et al.

CHEST (2020)

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Article Cardiac & Cardiovascular Systems

Long-Term Adverse Cardiac Outcomes in Patients With Sarcoidosis

Adelina Yafasova et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Weathering the Cytokine Storm in COVID-19: Therapeutic Implications

Giulia Iannaccone et al.

CARDIORENAL MEDICINE (2020)

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Article Medicine, General & Internal

Colchicine in Patients with Chronic Coronary Disease

Stefan M. Nidorf et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Medicine, General & Internal

Cardiovascular implications of COVID-19 versus influenza infection: a review

Muhammad Shahzeb Khan et al.

BMC MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

Management of Acute Myocarditis and Chronic Inflammatory Cardiomyopathy An Expert Consensus Document

Enrico Ammirati et al.

CIRCULATION-HEART FAILURE (2020)

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Article Cardiac & Cardiovascular Systems

Blocking the IL-1 signalling pathway prevents chronic viral myocarditis and cardiac remodeling

Lisa Kraft et al.

BASIC RESEARCH IN CARDIOLOGY (2019)

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Letter Cardiac & Cardiovascular Systems

Inflammasome Formation in Granulomas in Cardiac Sarcoidosis

Jordana Kron et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis

David G. Rosenthal et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Article Medicine, General & Internal

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

Jean-Claude Tardif et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Cardiac & Cardiovascular Systems

Cardiac Sarcoidosis

Pranav Mankad et al.

CURRENT CARDIOLOGY REPORTS (2019)

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Article Cardiac & Cardiovascular Systems

Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure

Brendan M. Everett et al.

CIRCULATION (2019)

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Review Cardiac & Cardiovascular Systems

Reassessing the Mechanisms of Acute Coronary Syndromes The Vulnerable Plaque and Superficial Erosion

Peter Libby et al.

CIRCULATION RESEARCH (2019)

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Article Medicine, General & Internal

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

Paul M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Usefulness of Canakinumab to Improve Exercise Capacity in Patients With Long-Term Systolic Heart Failure and Elevated C-Reactive Protein

Cory R. Trankle et al.

AMERICAN JOURNAL OF CARDIOLOGY (2018)

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Review Cardiac & Cardiovascular Systems

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Alena Grebe et al.

CIRCULATION RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Interleukin-1 beta has atheroprotective effects in advanced atherosclerotic lesions of mice

Delphine Gomez et al.

NATURE MEDICINE (2018)

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Article Immunology

Myocarditis: An Interleukin-1-Mediated Disease?

Giacomo De Luca et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

IL-1 Blockade in Patients With Heart Failure With Preserved Ejection Fraction: Results From DHART2

Benjamin W. Van Tassell et al.

CIRCULATION-HEART FAILURE (2018)

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Article Cardiac & Cardiovascular Systems

Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction

Nicole M. De Jesus et al.

HEART RHYTHM (2017)

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Article Cardiac & Cardiovascular Systems

Eosinophilic Myocarditis Characteristics, Treatment, and Outcomes

Michela Brambatti et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Medicine, General & Internal

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

P. M. Ridker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Oncology

Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy

Aneta Aleksova et al.

ONCOTARGET (2017)

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Article Immunology

Interleukin-1 Receptor Blockade Rescues Myocarditis-Associated End-Stage Heart Failure

Giulio Cavalli et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial)

Benjamin W. Van Tassell et al.

CIRCULATION-HEART FAILURE (2017)

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Article Cardiac & Cardiovascular Systems

NOD2 (Nucleotide-Binding Oligomerization Domain 2) Is a Major Pathogenic Mediator of Coxsackievirus B3-Induced Myocarditis

Carsten Tschoepe et al.

CIRCULATION-HEART FAILURE (2017)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2)

Benjamin W. Van Tassell et al.

CLINICAL CARDIOLOGY (2017)

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Article Critical Care Medicine

Treating Life-Threatening Myocarditis by Blocking Interleukin-1

Giulio Cavalli et al.

CRITICAL CARE MEDICINE (2016)

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Article Cardiac & Cardiovascular Systems

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-STelevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial+

Ola Kleveland et al.

EUROPEAN HEART JOURNAL (2016)

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Article Medicine, General & Internal

Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance and Corticosteroid Dependence The AIRTRIP Randomized Clinical Trial

Antonio Brucato et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Cardiac & Cardiovascular Systems

Interleukin-1 Blockade in Acute Decompensated Heart Failure: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Benjamin W. Van Tassell et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Comparative Safety of Interleukin-1 Blockade With Anakinra in Patients With ST-Segment Elevation Acute Myocardial Infarction (from the VCU-ART and VCU-ART2 Pilot Studies)

Antonio Abbate et al.

AMERICAN JOURNAL OF CARDIOLOGY (2015)

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Review Biochemistry & Molecular Biology

The Inflammasome in Myocardial Injury and Cardiac Remodeling

Stefano Toldo et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

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Article Cardiac & Cardiovascular Systems

2015 ESC Guidelines for the diagnosis and management of pericardial diseases The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC) Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS)

Yehuda Adler et al.

EUROPEAN HEART JOURNAL (2015)

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Article Cardiac & Cardiovascular Systems

Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation

Nicole M. De Jesus et al.

HEART RHYTHM (2015)

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Letter Cardiac & Cardiovascular Systems

Formation of the inflammasome during cardiac allograft rejection

Keyur B. Shah et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2015)

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Review Cardiac & Cardiovascular Systems

The Importance of NLRP3 Inflammasome in Heart Failure

Brittany Butts et al.

JOURNAL OF CARDIAC FAILURE (2015)

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Review Cardiac & Cardiovascular Systems

Pathophysiology and clinical management of cardiac sarcoidosis

Nabeel Hamzeh et al.

NATURE REVIEWS CARDIOLOGY (2015)

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Editorial Material Cardiac & Cardiovascular Systems

Anti-inflammatory therapies in acute coronary syndromes: is IL-1 blockade a solution?

Antonio Abbate et al.

EUROPEAN HEART JOURNAL (2015)

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Article Cardiac & Cardiovascular Systems

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

Allison C. Morton et al.

EUROPEAN HEART JOURNAL (2015)

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Article Cardiac & Cardiovascular Systems

Effects of Interleukin-1 Blockade With Anakinra on Aerobic Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction (from the D-HART Pilot Study)

Benjamin Wallace Van Tassell et al.

AMERICAN JOURNAL OF CARDIOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

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