4.7 Article

Original Research Response to programmed cell death protein 1 antibody in patients with Epstein-Barr virus-associated intrahepatic cholangiocarcinoma

Journal

EUROPEAN JOURNAL OF CANCER
Volume 194, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2023.113337

Keywords

Epstein-Barr virus; Intrahepatic cholangiocarcinoma; Programmed cell death protein 1; Immunotherapy

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This study evaluated the efficacy of PD-1 antibody therapy in EBVaICC and found that patients with EBVaICC had significantly longer overall survival when treated with PD-1 antibody.
Aim: Epstein-Barr virus-associated intrahepatic cholangiocarcinoma (EBVaICC) has a distinct genomic profile and increased CD3+ and CD8+ T cells infiltration. However, the efficacy of immunotherapy in EBVaICC remains largely unknown. This study aimed to assess the efficacy of programmed cell death protein 1 (PD-1) antibody therapy in EBVaICC. Methods: Patients with metastatic biliary tract cancer (BTC) diagnosed at Sun Yat-sen University Cancer Center from January 2016 to December 2021 were identified. In situ hybridisation was performed to detect EBV. Overall survival (OS) and progression-free survival (PFS) were measured. Results: A total of 698 patients with metastatic BTC were identified, of whom 39 (5.6%) had EBVaICC. Among the 136 patients who were not administered PD-1 antibody, the OS was similar between patients with EBVaICC and EBV-negative ICC (median OS 12.5 versus 9.5 months, respectively; P = 0.692). For the 205 patients who were administered PD-1 antibody, patients with EBVaICC had significantly longer OS than patients with EBV-negative ICC (median OS 24.9 versus 11.9 months, respectively; P = 0.004). Seventeen patients with EBVaICC were administered PD-1 antibody. Eight patients (47%) achieved a partial response, and 17 patients achieved disease control. The median PFS was 17.5 months. Conclusions: This study identified a clinically actionable subset of patients with EBVaICC with a promising response to the PD-1 antibody. (c) 2023 Elsevier Ltd. All rights reserved.

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