Brain endothelium: a nexus for cerebral small vessel disease

Article Multidisciplinary Sciences

A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

Andrew C. Yang et al.

Summary: This study provides a molecular map of vascular and perivascular cell types in the human brain using a method called VINE-seq, revealing their contributions to Alzheimer's disease risk.

NATURE (2022)

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Article Multidisciplinary Sciences

Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra et al.

Summary: This study identified 89 independent loci associated with stroke and its subtypes through cross-ancestry GWAS analyses, with high replication rates for both primary and secondary stroke risk loci. It also revealed potential causal genes, variants, and drug targets, and demonstrated the predictive power of genetic risk scores for ischemic stroke across different ancestries.

NATURE (2022)

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Review Neurosciences

Revisiting the neurovascular unit

Samantha Schaeffer et al.

Summary: Schaeffer and Iadecola reviewed the heterogeneity of the neurovasculature and discussed the limitations of the neurovascular unit concept and the molecular diversity of cerebrovascular cells. They proposed the concept of a 'neurovascular complex' composed of segmentally diverse functional modules that implement coordinated vascular responses to central and peripheral signals.

NATURE NEUROSCIENCE (2021)

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Article Medicine, Research & Experimental

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease

Masayo Koide et al.

Summary: Chronic hypertension disrupts brain microcirculation by reducing the activity of the capillary endothelial cell inward-rectifier potassium channel Kir2.1. Amlodipine, a calcium channel blocker, but not losartan, an angiotensin II type 1 receptor blocker, can prevent hypertension-related damage to functional hyperemia. The losartan-induced aldosterone breakthrough may lead to elevated plasma aldosterone levels and contribute to the decline in functional hyperemia.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Clinical Neurology