4.7 Article

Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 25, Pages 5326-5329

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08613a

Keywords

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Funding

  1. UCSD
  2. NIH Pathway to Independence Award [NIBIB: 5 R00 EB013446-04]
  3. G. Harold & Leila Y. Mathers Foundation
  4. UCSD Molecular Biophysics Training Program through the National Institute of Health [NIGMS: T32 GM08326]
  5. NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R00EB013446] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008326] Funding Source: NIH RePORTER

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Influenza viruses bind to mucosal glycans to gain entry into a host organism and initiate infection. The target glycans are often displayed in multivalent arrangements on proteins; however, how glycan presentation influences viral specificity is poorly understood. Here, we report a microarray platform approximating native glycan display to facilitate such studies.

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