Journal
ENVIRONMENTAL TOXICOLOGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/tox.24005
Keywords
MNPs; early vascular pathologies; PM; lipid metabolism; JAK-STAT pathway
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This study demonstrates the proatherogenic effect of magnetite nanoparticles (MNPs) under high-fat dietary patterns, resulting in pathological changes including aortic wall thickening, fiber disorganization, and inflammation. MNPs are identified as a key component of atherogenic toxicity and disturb lipid metabolism, leading to lipid accumulation and metabolic disorder.
Magnetite nanoparticles (MNPs) have been extensively detected in the atmospheric environment and implicated as a prominent threat to atherosclerosis, a chronic vascular inflammatory disease. Due to globalization and economic development, the dramatic shift in diet from traditional to high-fat dietary patterns aggravated atherosclerosis progression induced by environmental factors. However, limited knowledge is available regarding vascular risks and underlying mechanisms of airborne MNPs in high-risk populations with high-fat dietary habits. Herein, we demonstrated that MNPs exerted a proatherogenic effect under high-fat dietary patterns, leading to aortic wall thickening, elastic fiber disorganization, macrophage infiltration, and local inflammation. Based on the correlation analysis between MNPs and PM group, we identified that MNPs might be a key PM component in atherogenic toxicity. MNPs exposure disturbed the dynamic process of lipid metabolism, manifested as aortic lipid accumulation, dyslipidemia, and hepatic lipid metabolism disorder, which was modulated by the JAK-STAT pathway. Overall, these findings provide new insight into understanding the cardiovascular risks and mechanisms of MNPs among high-risk populations.
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