4.8 Article

Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Emerging and Legacy Perfluoroalkyl Substances in Breastfed Chinese Infants: Renal Clearance, Body Burden, and Implications

Jingzhi Yao et al.

Summary: The study investigates the levels of PFAS in Chinese breast milk and urine samples from infants. The results show the widespread occurrence of emerging PFAS in human milk, indicating potential health risks for newborns.

ENVIRONMENTAL HEALTH PERSPECTIVES (2023)

Article Agriculture, Multidisciplinary

Uptake of Ultrashort Chain, Emerging, and Legacy Per- and Polyfluoroalkyl Substances (PFAS) in Edible Mushrooms (Agaricus spp.) Grown in a Polluted Substrate

Astrid Solvag Nesse et al.

Summary: The uptake of PFAS in mushrooms was investigated, and it was found that the accumulation was low and chain-length dependent. This is the first study of the uptake of emerging and ultra-short chain PFAS in mushrooms, and the results indicate very low accumulation.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Article Engineering, Environmental

Trophic behaviors of PFOA and its alternatives perfluoroalkyl ether carboxylic acids (PFECAs) in a coastal food web

Yanan Li et al.

Summary: The production and usage of perfluoroalkyl ether carboxylic acids (PFECAs) as alternatives to legacy poly- and perfluoroalkyl substances (PFAS) have increased recently. However, little is known about the bioaccumulation and trophic behaviors of emerging PFECAs in coastal ecosystems. This study investigated the bioaccumulation and trophodynamics of perfluorooctanoic acid (PFOA) and its substitutes (PFECAs) in Laizhou Bay, China. The dominant compounds in the ecosystem of Laizhou Bay were hexafluoropropylene oxide trimer acid (HFPO-TrA), perfluoro-2-methoxyacetic acid (PFMOAA) and PFOA.

JOURNAL OF HAZARDOUS MATERIALS (2023)

Review Multidisciplinary Sciences

Per- and polyfluoroalkyl substances in the environment

Marina G. Evich et al.

Summary: PFAS has become a symbol of environmental contamination, attracting public, scientific, and regulatory concern. These compounds are globally distributed through atmospheric and aqueous releases, and they accumulate in biota through multiple pathways. Efforts to remediate PFAS-contaminated matrices are still in their early stages, with a focus on research targeting drinking water.

SCIENCE (2022)

Article Engineering, Environmental

First Report on the Bioaccumulation and Trophic Transfer of Perfluoroalkyl Ether Carboxylic Acids in Estuarine Food Web

Yanan Li et al.

Summary: This research provides the first published data on the bioaccumulation and trophic transfer characteristics of PFECAs in a source-impacted estuary. It found that certain PFECAs biomagnify along the food chain, while others undergo biomagnification. This poses exposure risks and potential health hazards to consumers.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Engineering, Environmental

Quantifying Indirect Contribution from Precursors to Human Body Burden of Legacy PFASs Based on Paired Blood and One-Week Duplicate Diet

Xin Chen et al.

Summary: The restriction on legacy PFASs has led to increased use and contamination of their precursors and novel alternatives. This study measured 24 PFASs in human blood, urine, and exposure matrices, and found that 6:2 Cl-PFESA was a significant contributor. It was estimated that about 19% of PFOS in humans was from its precursors, suggesting indirect exposure may play a role in PFAS contamination.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Engineering, Environmental

Nontargeted Identification and Temporal Trends of Per- and Polyfluoroalkyl Substances in a Fluorochemical Industrial Zone and Adjacent Taihu Lake

Jingzhi Yao et al.

Summary: This study discovered new species of PFASs in effluent and surface waters from a fluorochemical industrial zone. A novel compound called C7 HFPO-TA was found to have extremely high concentrations in the effluent and its concentration continued to grow in Taihu Lake. Further research on C7 HFPO-TA is urgently needed.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Environmental Sciences

Per- and polyfluoroalkyl substances in the atmosphere of waste management infrastructures: Uncovering secondary fluorotelomer alcohols, particle size distribution, and human inhalation exposure

Huiju Lin et al.

Summary: This study investigates the atmospheric releases of per- and polyfluoroalkyl substances (PFAS) from waste management infrastructures (WMIs) in urban and rural areas of Hong Kong, China. The study reveals that fluorotelomer alcohols (FTOHs) and perfluoroalkane sulfonamides are the predominant PFAS types found. It also demonstrates the release of less frequently observed intermediate products during waste treatment. Additionally, the study estimates the lung deposition fluxes of PFAS and finds that inhaled particulate PFAS are mainly deposited in the head airway. The cumulative daily inhalation dose of gaseous and particulate PFAS ranges from 81.9 to 265 pg/kg/d.

ENVIRONMENT INTERNATIONAL (2022)

Article Environmental Sciences

Drinking Water-Associated PFAS and Fluoroethers and Lipid Outcomes in the GenX Exposure Study

Emma M. Rosen et al.

Summary: This study investigated the association between drinking water contamination with fluoroethers and legacy PFAS and lipid levels in residents of Wilmington. The results showed that PFOS and PFNA were associated with higher total and non-HDL cholesterol levels, especially in older adults. In the presence of legacy PFAS, fluoroethers appeared to be associated with higher HDL cholesterol levels but not non-HDL cholesterol levels.

ENVIRONMENTAL HEALTH PERSPECTIVES (2022)

Article Public, Environmental & Occupational Health

Occurrence and Risks of Per- and Polyfluoroalkyl Substances in Shellfish

Nathan G. Giffard et al.

Summary: This review summarizes the occurrence of PFAS in shellfish and highlights the scientific gaps in terms of bioaccumulation and protection of shellfish consumers. It calls for researchers to standardize sampling techniques and analytical methodologies, as well as to increase the range of geographic locations where samples are collected to better understand worldwide PFAS contamination. Additionally, the review emphasizes the potential risks of PFAS to frequent shellfish consumers and the need for further research to protect them and inform health protective policies and advisories.

CURRENT ENVIRONMENTAL HEALTH REPORTS (2022)

Article Public, Environmental & Occupational Health

Exposure to Emerging and Legacy Polyfluoroalkyl Substances in the Sixth Total Diet Study - China, 2016-2019

Yuxin Wang et al.

Summary: This report adds new information about perfluoroalkyl substances (PFASs) and emphasizes the need for continuous monitoring of PFAS levels in certain food categories, especially 6:2 Cl-PFESA.

CHINA CDC WEEKLY (2022)

Article Environmental Sciences

Atmospheric diffusion of perfluoroalkyl acids emitted from fluorochemical industry and its associated health risks

Pei Wang et al.

Summary: The fluorochemical industry is a significant source of atmospheric PFAAs, with PFOA being dominant in the air. Inhalation of PFOA from indoor air poses a potential health risk to individuals.

ENVIRONMENT INTERNATIONAL (2021)

Article Environmental Sciences

Chlorinated polyfluoroalkyl ether sulfonic acids in fish, dust, drinking water and human serum: From external exposure to internal doses

Yuan Wang et al.

Summary: Exposure to Cl-PFESAs and legacy PFASs is widespread in Shijiazhuang, China, with 6:2 Cl-PFESA being a major compound in serum. While fish consumption is a main contributor to PFASs exposure, the increasing contribution from dust ingestion, especially for 6:2 Cl-PFESA, should not be ignored. Further studies on detailed external sources and risk assessments of Cl-PFESAs are recommended, considering their widespread exposure and increasing levels in the general population.

ENVIRONMENT INTERNATIONAL (2021)

Article Environmental Sciences

External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications

Xuemin Feng et al.

Summary: The study found that HFPO-DA was detected in indoor dust and drinking water with low bioaccumulation potential, while HFPO-TA had a comparable estimated daily intake to PFOA but higher concentration in urine, suggesting faster elimination. Predicted concentrations of PFOA in serum based on urine measurements were close to measured values, indicating distinct internal exposure, while measured concentrations of HFPO in serum were lower than expected, implying faster elimination in humans.

ENVIRONMENT INTERNATIONAL (2021)

Article Engineering, Environmental

Per- and Polyfluoroalkyl Substance (PFAS) Transport from Groundwater to Streams near a PFAS Manufacturing Facility in North Carolina, USA

Marie-Amelie Petre et al.

Summary: This study quantifies the transport of PFAS from groundwater to tributaries of the Cape Fear River near a PFAS manufacturing facility in North Carolina, USA. The results indicate that PFAS from groundwater enter the Cape Fear River through tributaries, potentially causing long-term surface water contamination and impacting downstream drinking water supplies.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Engineering, Environmental

Tissue-Specific Distribution of Legacy and Novel Per- and Polyfluoroalkyl Substances in Juvenile Seabirds

Anna R. Robuck et al.

Summary: The study analyzed 36 legacy and emerging PFAS in seabird tissues, with PFOS being the dominant compound and PFCAs dominating in brain. Emerging PFEAs were found to preferentially partition into blood. Future monitoring and toxicological studies should focus on novel PFAS and long-chain PFCAs in multiple tissues while exploring the unique binding mechanisms of multi-ether PFEAs.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2021)

Article Engineering, Environmental

Chronic exposure to PFO4DA and PFO5DoDA, two perfluoroalkyl ether carboxylic acids (PFECAs), suppresses hepatic stress signals and disturbs glucose and lipid metabolism in male mice

Jiamiao Chen et al.

Summary: Perfluoroalkyl ether carboxylic acids (PFECAs), including substances like PFO4DA and PFO5DoDA, have been found in polluted regions in both surface water and volunteer blood samples. The study showed that PFO5DoDA had a longer serum half-life and stronger hepatic bioaccumulation compared to PFO4DA, contributing to its stronger hepatotoxicity. Chronic exposure to these compounds led to weight gain, disrupted stress signals, and disturbed glucose and lipid metabolism in the liver.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Engineering, Environmental

Occurrence of Novel Perfluoroalkyl Ether Carboxylic Acids in River Water and Human Urine Quantified by a Simple Liquid-Liquid Microextraction Approach Coupled with LC-MS/MS

Jingzhi Yao et al.

Summary: A simple and sensitive liquid-liquid microextraction method coupled with liquid chromatography-tandem mass spectrometry was developed to quantify 11 emerging PFECAs in river water and human urine, with excellent detection limits and accuracy. Application of the method for the Xiaoqing River detected 10 of the 11 emerging PFECAs present, and PFMOAA was found in a high percentage of human urine samples, indicating the need for further research on its fate, transport, and exposure pathways.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2021)

Review Environmental Sciences

Review on perfluoroalkyl and polyfluoroalkyl substances (PFASs) in the Chinese atmospheric environment

Qi Wang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Food Science & Technology

Risk to human health related to the presence of perfluoroalkyl substances in food

Dieter Schrenk et al.

EFSA JOURNAL (2020)

Article Engineering, Environmental

Assessing Human Health Risks from Per- and Polyfluoroalkyl Substance (PFAS)-Impacted Vegetable Consumption: A Tiered Modeling Approach

Juliane B. Brown et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

Article Environmental Sciences

Sources, Fate, and Plant Uptake in Agricultural Systems of Per- and Polyfluoroalkyl Substances

M. Christina Schilling Costello et al.

CURRENT POLLUTION REPORTS (2020)

Article Environmental Sciences

Emerging per- and polyfluoroalkyl substances (PFASs) in surface water and sediment of the North and Baltic Seas

Hanna Joerss et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Environmental Sciences

Are perfluoroalkyl substances in water and fish from drinking water source the major pathways towards human health risk?

Jing Meng et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019)

Article Engineering, Environmental

Worldwide Distribution of Novel Perfluoroether Carboxylic and Sulfonic Acids in Surface Water

Yitao Pan et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

Article Engineering, Environmental

Geographical Differences in Dietary Exposure to Perfluoroalkyl Acids between Manufacturing and Application Regions in China

Haiyan Zhang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Engineering, Environmental

First Report on the Occurrence and Bioaccumulation of Hexafluoropropylene Oxide Trimer Acid: An Emerging Concern

Yitao Pan et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Environmental Sciences

A broad cocktail of environmental pollutants found in eggs of three seabird species from remote colonies in Norway

Sandra Huber et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2015)

Article Engineering, Environmental

Perfluoroalkyl Acid Uptake in Lettuce (Lactuca sativa) and Strawberry (Fragaria ananassa) Irrigated with Reclaimed Water

Andrea C. Blaine et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Article Environmental Sciences

Perfluoroalkyl and polyfluoroalkyl substances in sediments from South Bohai coastal watersheds, China

Zhaoyun Zhu et al.

MARINE POLLUTION BULLETIN (2014)

Article Engineering, Environmental

Uptake of Perfluorinated Alkyl Acids by Hydroponically Grown Lettuce (Lactuca sativa)

Sebastian Felizeter et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)