4.8 Article

Unravelling High-Molecular-Weight DBP Toxicity Drivers in Chlorinated and Chloraminated Drinking Water: Effect-Directed Analysis of Molecular Weight Fractions

Related references

Note: Only part of the references are listed.
Article Green & Sustainable Science & Technology

Toxicological assessment of potable reuse and conventional drinking waters

Stephanie S. Lau et al.

Summary: Potable reuse offers a reliable and sustainable solution to water shortage, but implementation is hindered by concerns over water quality and health risks. A comparative analysis shows that potable reuse waters have lower cytotoxicity than traditional drinking waters, indicating that it can provide a safe alternative water supply.

NATURE SUSTAINABILITY (2023)

Article Engineering, Environmental

Drivers of Disinfection Byproduct Cytotoxicity in US Drinking Water: Should Other DBPs Be Considered for Regulation?

Joshua M. Allen et al.

Summary: This study identifies key drivers of toxicity in drinking water in the United States, focusing on disinfection byproducts (DBPs). The research highlights the importance of unregulated haloacetonitriles and iodoacetic acids as significant toxicity drivers, especially in waters impacted by seawater. The findings suggest that future research should prioritize these DBPs for potential regulation.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Engineering, Environmental

Effect-Directed Analysis Based on the Reduced Human Transcriptome (RHT) to Identify Organic Contaminants in Source and Tap Waters along the Yangtze River

Jing Guo et al.

Summary: A RHT-based effect-directed analysis method was developed to comprehensively evaluate the effects and identify key contributors of contaminants in source waters. The method revealed more differentially expressed genes and pathways in the water sources along the Yangtze River, indicating heavier pollution. Hormone and immune pathways, especially the estrogen receptor pathway, were found to be the most noteworthy. Several pollutants were systematically identified and their contributions to water quality were determined.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Environmental Sciences

How well does XAD resin extraction recover halogenated disinfection byproducts for comprehensive identification and toxicity testing?

Xiaobin Liao et al.

Summary: In this study, the adsorption and elution efficiency of DAX-8/XAD-2 layered resins for extracting 66 DBPs from water were evaluated. The results revealed that the adsorption capacity varied among different classes of DBPs, with trihalomethanes (THMs) being the most efficiently adsorbed. The recovery efficiency of most DBPs was comparable to their adsorption, and the polarity and molecular weight of DBPs were the key factors determining their recovery. Underestimation of toxicity could occur for certain DBPs with low recovery rates.

JOURNAL OF ENVIRONMENTAL SCIENCES (2022)

Article Engineering, Environmental

Changes in molecular dissolved organic matter and disinfection by-product formation during granular activated carbon filtration by unknown screening analysis with Orbitrap mass spectrometry

Thanadul Chantarasrisuriyawong et al.

Summary: This research investigates the removal of dissolved organic matter (DOM) and the minimization of disinfection by-product (DBP) formation by using pilot-scale coal-and coconut-based granular activated carbon filtrations. The results show that the coal-based activated carbon is more effective in the removal of dissolved organic carbon and prolongs adsorption longer than the coconut-based activated carbon. Different types of compounds are selectively removed by the two activated carbon filters. A biofilm is developed on the activated carbon filters after 60 days of filtration, leading to the formation of microbial products. Chlorination results in a decrease in many organic compounds and the formation of chlorinated DBPs.

WATER RESEARCH (2022)

Article Engineering, Environmental

Halocyclopentadienes: An Emerging Class of Toxic DBPs in Chlor(am)inated Drinking Water

Jiafu Li et al.

Summary: Although more than 700 disinfection by-products (DBPs) have been identified, most DBPs in drinking water are still unknown. This study identified six new alicyclic DBPs in chlorinated and chloraminated drinking water and proposed their formation pathways. These new DBPs have significantly higher toxicity compared to regulated DBPs, highlighting their importance in drinking water quality and human health exposure.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Environmental Sciences

Characterization of lower Phong river dissolved organic matters and formations of unknown chlorine dioxide and chlorine disinfection by-products by Orbitrap mass spectrometry

Thirawit Prasert et al.

Summary: The characteristics of dissolved organic matter in the lower Phong River in Thailand were found to be influenced by domestic wastewater discharges, anthropogenic activities, and surface runoff, with differences in molecular composition observed between dry season and rainy season. Disinfection by chlorine or chlorine dioxide resulted in the formation of both chlorinated and non-chlorinated disinfection byproducts, with differences in the types and characteristics of DBPs produced by each disinfectant.

CHEMOSPHERE (2021)

Review Environmental Sciences

New methods for identification of disinfection byproducts of toxicological relevance: Progress and future directions

Nicholas J. P. Wawryk et al.

Summary: This article summarizes advances in new workflows for DBP analysis, discusses necessary considerations for each step, and highlights the potential of new MS-based approaches in identifying novel DBPs.

JOURNAL OF ENVIRONMENTAL SCIENCES (2021)

Article Engineering, Environmental

Making Swimming Pools Safer: Does Copper-Silver Ionization with Chlorine Lower the Toxicity and Disinfection Byproduct Formation?

Joshua M. Allen et al.

Summary: This study investigated a complementary disinfectant to chlorine, copper-silver ionization (CSI), and found that using a lower chlorine residual and CSI in swimming pools could decrease emerging disinfection byproducts (DBPs) concentrations by up to 80% and cytotoxicity by up to 70%. Some DBPs were quantified for the first time in pools, and the NAC thiol reactivity was significantly correlated to cytotoxicity, which could be useful for predicting the cytotoxicity of swimming pool waters in future studies.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Engineering, Environmental

A Novel Method for Unraveling the Black Box of Dissolved Organic Matter in Soils by FT-ICR-MS Coupled with Induction-Based Nanospray Ionization

Shuchai Gan et al.

Summary: This study proposed a novel method for characterizing dissolved organic matter (DOM) in soils, reducing ion suppression effect and avoiding the need for solid-phase extraction (SPE). The new method detected a more diverse range of compound types, providing a more complete understanding of DOM in soils.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2021)

Article Engineering, Environmental

How Much of the Total Organic Halogen and Developmental Toxicity of Chlorinated Drinking Water Might Be Attributed to Aromatic Halogenated DBPs?

Jiarui Han et al.

Summary: The study developed an effective method with ultraperformance liquid chromatography to analyze the DBP mixture from chlorination of bromide-rich raw water, separating them into aliphatic and aromatic fractions. The results showed that aromatic fractions accounted for a significant portion of the TOX and developmental toxicity in the original chlorinated water samples, indicating that the overall developmental toxicity of chlorinated water is mainly attributed to aromatic halo-DBPs with high bioconcentration potential.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Review Chemistry, Analytical

Water Analysis: Emerging Contaminants and Current Issues

Susan D. Richardson et al.

ANALYTICAL CHEMISTRY (2020)

Article Engineering, Environmental

To regulate or not to regulate? What to do with more toxic disinfection by-products?

Susan D. Richardson et al.

JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING (2020)

Article Engineering, Environmental

Waterworks-specific composition of drinking water disinfection by-products

Anna Andersson et al.

ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY (2019)

Article Chemistry, Analytical

21 Tesla FT-ICR Mass Spectrometer for Ultrahigh-Resolution Analysis of Complex Organic Mixtures

Donald F. Smith et al.

ANALYTICAL CHEMISTRY (2018)

Article Engineering, Environmental

Drinking Water Disinfection Byproducts (DBPs) and Human Health Effects: Multidisciplinary Challenges and Opportunities

Xing-Fang Li et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

Article Engineering, Environmental

Thiol Reactivity Analyses To Predict Mammalian Cell Cytotoxicity of Water Samples

Shengkun Dong et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2018)

Article Environmental Sciences

TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water

Michael J. Plewa et al.

JOURNAL OF ENVIRONMENTAL SCIENCES (2017)

Review Environmental Sciences

CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products: An updated review

Elizabeth D. Wagner et al.

JOURNAL OF ENVIRONMENTAL SCIENCES (2017)

Article Engineering, Environmental

Identification and Comparative Mammalian Cell Cytotoxicity of New lodo-Phenolic Disinfection Byproducts in Chloraminated Oil and Gas Wastewaters

Hannah K. Liberatore et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2017)

Article Engineering, Environmental

Characterization of Disinfection By-Products from Chromatographically Isolated NOM through High-Resolution Mass Spectrometry

Bradley D. Harris et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2015)

Article Biochemical Research Methods

21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

Christopher L. Hendrickson et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2015)

Article Engineering, Environmental

Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays

Beate I. Escher et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Article Engineering, Environmental

Toxic Impact of Bromide and Iodide on Drinking Water Disinfected with Chlorine or Chloramines

Yang Yang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Article Engineering, Environmental

Selective Chlorination of Natural Organic Matter: Identification of Previously Unknown Disinfection Byproducts

Elin E. Lavonen et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Engineering, Environmental

Occurrence and Toxicity of Disinfection Byproducts in European Drinking Waters in Relation with the HIWATE Epidemiology Study

Clara H. Jeong et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)

Article Engineering, Environmental

Formation of Toxic Iodinated Disinfection By-Products from Compounds Used in Medical Imaging

Stephen E. Duirk et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)

Article Engineering, Environmental

Formation and Decomposition of New and Unknown Polar Brominated Disinfection Byproducts during Chlorination

Hongyan Zhai et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)

Article Chemistry, Multidisciplinary

Carbon oxidation state as a metric for describing the chemistry of atmospheric organic aerosol

Jesse H. Kroll et al.

NATURE CHEMISTRY (2011)

Article Engineering, Environmental

Comparative Human Cell Toxicogenomic Analysis of Monohaloacetic Acid Drinking Water Disinfection Byproducts

Matias S. Attene-Ramos et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2010)

Article Engineering, Environmental

Comparison of Byproduct Formation in Waters Treated with Chlorine and Iodine: Relevance to Point-of-Use Treatment

Emma Marie Smith et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2010)

Article Engineering, Environmental

Mammalian Cell DNA Damage and Repair Kinetics of Monohaloacetic Acid Drinking Water Disinfection By-Products

Yukako Komaki et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2009)

Article Engineering, Environmental

A Picture of Polar Iodinated Disinfection Byproducts in Drinking Water by (UPLC/)ESI-tqMS

Guoyu Ding et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2009)

Review Biochemical Research Methods

How to confirm identified toxicants in effect-directed analysis

Werner Brack et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)

Article Engineering, Environmental

Occurrence and Mammalian Cell Toxicity of Iodinated Disinfection Byproducts in Drinking Water

Susan D. Richardson et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2008)

Review Biotechnology & Applied Microbiology

Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: A review and roadmap for research

Susan D. Richardson et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2007)

Article Biotechnology & Applied Microbiology

Repair kinetics of specific types of nitroso-induced DNA damage using the comet assay in human cells

Sandrine Lacoste et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)

Article Engineering, Environmental

Comparison of disinfection byproduct formation from chlorine and alternative disinfectants

Guanghui Hua et al.

WATER RESEARCH (2007)

Article Geochemistry & Geophysics

Characterization of a major refractory component of marine dissolved organic matter

N Hertkorn et al.

GEOCHIMICA ET COSMOCHIMICA ACTA (2006)

Article Biochemical Research Methods

From mass to structure: an aromaticity index for high-resolution mass data of natural organic matter

BP Koch et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2006)

Article Engineering, Environmental

Chemical and biological characterization of newly discovered lodoacid drinking water disinfection byproducts

MJ Plewa et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2004)

Article Engineering, Environmental

What contributes to the combined effect of a complex mixture?

R Altenburger et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2004)

Article Engineering, Environmental

Chlorination of phenols: Kinetics and formation of chloroform

H Gallard et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2002)

Article Engineering, Environmental

Formation of iodo-trihalomethanes during disinfection and oxidation of iodide containing waters

Y Bichsel et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2000)

Article Food Science & Technology

The epidemiology of chemical contaminants of drinking water

RL Calderon

FOOD AND CHEMICAL TOXICOLOGY (2000)