Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 40, Pages 8492-8495Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01869b
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Funding
- TUBITAK 1001 grant [213M315]
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In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
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