4.7 Article

Prenatal exposure to replacement flame retardants and organophosphate esters and childhood adverse respiratory outcomes

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Exposure to dust organophosphate and replacement brominated flame retardants during infancy and risk of subsequent adverse respiratory outcomes

Angelico Mendy et al.

Summary: Children's exposure to flame retardants in indoor environments, particularly through inhalation, may have an impact on respiratory health outcomes during childhood. The associations between early life exposure to novel organophosphate (OPFRs) and replacement brominated flame retardants (RBFRs) and adverse respiratory outcomes were investigated in a prospective birth cohort.

ENVIRONMENTAL RESEARCH (2023)

Article Environmental Sciences

Comparison of the mechanisms of estrogen disrupting effects between triphenyl phosphate (TPhP) and tris(1,3-dichloro-2-propyl) phosphate (TDCIPP)

Xiaoya Ji et al.

Summary: TPhP acts as ERα agonist and recruits SRC1 and SRC3, while TDCIPP acts as ERα antagonist. However, both activate estrogen pathway through GPER. Furthermore, they have different effects on E2 synthesis and hormone levels as shown by molecular docking and cell assays.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Allergy

Comorbidities in childhood-onset and adult-onset asthma

Angelico Mendy et al.

Summary: Adult-onset asthma is associated with higher odds of comorbidities such as obesity, dyslipidemia, arthritis, and diabetes compared to childhood-onset asthma. Older age of asthma diagnosis is associated with higher odds of diabetes and hypertension, while younger age of asthma diagnosis is associated with higher odds of chronic obstructive pulmonary disease.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

Long term exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in reproductive hormones, vitellogenin, antioxidant enzymes, and histology of gonads in zebrafish (Danio rerio): In vivo and computational analysis

Jesudass Sutha et al.

Summary: In this study, in vivo experiments and in-silico docking were used to explore the toxic mechanisms of tris (2-chloroethyl) phosphate (TCEP) in zebrafish. The results showed that TCEP exposure led to significant changes in steroid hormones, antioxidant enzymes, and histopathological features in the fish. Additionally, docking studies indicated that TCEP had binding affinity with estrogen and androgen receptors.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2022)

Article Environmental Sciences

Prenatal exposure to triphenyl phosphate activated PPARγ in placental trophoblasts and impaired pregnancy outcomes

Jiabin Hong et al.

Summary: The study demonstrates that prenatal exposure to TPhP can negatively impact pregnancy outcomes, potentially through the regulation of trophoblast cell function by PPARγ.

ENVIRONMENTAL POLLUTION (2022)

Article Cardiac & Cardiovascular Systems

Urinary volatile organic compound metabolites and reduced lung function in US adults

Angelico Mendy et al.

Summary: This study is the first representative sample of the US adult population to reveal associations between urinary metabolites of acrylonitrile, propylene oxide, and styrene and reduced lung function at non-occupational exposures. The results also support previous evidence of the association between acrylamide and acrolein and adverse respiratory outcomes.

RESPIRATORY MEDICINE (2022)

Review Cell Biology

The Potential Role of PPARs in the Fetal Origins of Adult Disease

Jun Guo et al.

Summary: The fetal origins of adult disease hypothesis suggests that events during early development can significantly affect an individual's risk for developing adult diseases. Peroxisome proliferator-activated receptors (PPARs), a type of nuclear hormone receptor, play a crucial role in the transition from embryo to fetus and are influenced by adverse events in early life. The methylation pattern of PPARs in offspring organs can affect development and health throughout life, and potentially impact future generations.

CELLS (2022)

Article Respiratory System

Serum antioxidant vitamins and respiratory morbidity and mortality: a pooled analysis

Paivi M. Salo et al.

Summary: In this study, lower serum levels of vitamins A, C, D, and E were found to be associated with increased respiratory morbidity and/or mortality in the U.S. adult population. These results underscore the importance of antioxidant vitamins in respiratory health.

RESPIRATORY RESEARCH (2022)

Review Environmental Sciences

New understanding of novel brominated flame retardants (NBFRs): Neuro (endocrine) toxicity

Liying Dong et al.

Summary: The neurotoxic effects of novel brominated flame retardants (NBFRs) are mainly manifested in direct neurotoxicity and disruption of the neuroendocrine system, affecting neurobehavior and reproductive development. The mechanism is related to the complex interaction of neural and endocrine signals.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Exposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption

Minmin Hou et al.

Summary: Human exposure to organophosphate esters (OPEs) poses potential health risks, especially for elderly individuals with reduced metabolic and excretory capacities. Inhalation, food ingestion, and dermal absorption are the main exposure pathways. Further studies are needed to explore the potential health effects of OPE exposure in the elderly populations.

ENVIRONMENT INTERNATIONAL (2021)

Article Engineering, Environmental

Trimester-specific effects of maternal exposure to organophosphate flame retardants on offspring size at birth: A prospective cohort study in China

Dan Luo et al.

Summary: The study found that prenatal exposure to certain organophosphate flame retardants (OPFRs) during the third trimester may negatively impact fetal growth, with BDCIPP and BBOEP having the most significant developmental toxicity effects on fetuses in the third trimester.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Review Allergy

Prenatal Exposure to Endocrine-Disrupting Chemicals and Asthma and Allergic Diseases

M. Casas et al.

JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY (2020)

Review Engineering, Environmental

Organophosphate Ester Flame Retardants: Are They a Regrettable Substitution for Polybrominated Diphenyl Ethers?

Arlene Blum et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2019)

Article Environmental Sciences

Prenatal and postnatal polybrominated diphenyl ether exposure and visual spatial abilities in children

Ann M. Vuong et al.

ENVIRONMENTAL RESEARCH (2017)

Article Engineering, Environmental

Organophosphorus Flame Retardants in Pregnant Women and Their Transfer to Chorionic Villi

Fanrong Zhao et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Pediatrics

Prenatal exposure to bisphenol A and risk of allergic diseases in early life

Aifen Zhou et al.

PEDIATRIC RESEARCH (2017)

Review Allergy

Prenatal exposures and the development of childhood wheezing illnesses

Christian Rosas-Salazar et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Engineering, Environmental

Consumer Product Chemicals in Indoor Dust: A Quantitative Meta-analysis of US Studies

Susanna D. Mitro et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2016)

Article Public, Environmental & Occupational Health

Bisphenol A exposure may increase the risk of development of atopic disorders in children

I-Jen Wang et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2016)

Article Toxicology

Transplacental and Lactational Transfer of Firemaster (R) 550 Components in Dosed Wistar Rats

Allison L. Phillips et al.

TOXICOLOGICAL SCIENCES (2016)

Article Critical Care Medicine

Prenatal Particulate Air Pollution and Asthma Onset in Urban Children Identifying Sensitive Windows and Sex Differences

Hsiao-Hsien Leon Hsu et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Review Toxicology

Human exposure to PBDE and critical evaluation of health hazards

Victoria Linares et al.

ARCHIVES OF TOXICOLOGY (2015)

Article Engineering, Environmental

Potential Estrogenic Effects of Phosphorus-Containing Flame Retardants

Quan Zhang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Review Allergy

Estrogen effects in allergy and asthma

Rana S. Bonds et al.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Environmental Sciences

Early-Life Exposure to Outdoor Air Pollution and Respiratory Health, Ear Infections, and Eczema in Infants from the INMA Study

Inmaculada Aguilera et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2013)

Article Allergy

Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children

Kathleen M. Donohue et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Biochemistry & Molecular Biology

Mechanisms of respiratory innervation during embryonic development

Linh Aven et al.

ORGANOGENESIS (2013)

Article Respiratory System

Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations

Philip H. Quanjer et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

Article Public, Environmental & Occupational Health

Carpet-dust chemicals as measures of exposure: Implications of variability

Todd P. Whitehead et al.

EMERGING THEMES IN EPIDEMIOLOGY (2012)

Article Engineering, Environmental

Susceptibility of Children to Environmental Pollutants

Peter D. Sly et al.

ENVIRONMENTAL CHALLENGES IN THE PACIFIC BASIN (2008)

Article Respiratory System

Standardisation of spirometry

MR Miller et al.

EUROPEAN RESPIRATORY JOURNAL (2005)

Article Critical Care Medicine

Association between TNFA polymorphism and the development of asthma in the Japanese population

E Noguchi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)