Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 14, Pages 2999-3002Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09274k
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Funding
- National Natural Science Foundation of China [NSFC-21174126, NSFC-51333005, NSFC-51303154, NSFC-51273177]
- National Science Fund for Distinguished Young Scholars [51025312]
- National Basic Research Program of China [2011CB606203]
- Research Fund for the Doctoral Program of Higher Education of China [20110101110037, 20120101130013]
- State Key Laboratory of Supramolecular Structure and Materials [sklssm201316]
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A novel type of dual pH-responsive supramolecular prodrug micelles based on host-guest interactions of water-soluble pillar[5] arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.
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