4.7 Article

Activation of Atg5-dependent placental lipophagy ameliorates cadmium-induced fetal growth restriction

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Assessment of soil heavy metal pollution in provinces of China based on different soil types: From normalization to soil quality criteria and ecological risk assessment

Jiawen Zhang et al.

Summary: This study developed a framework for an integrated risk assessment system to derive soil quality criteria for heavy metals applicable to different soil types and to assess ecological risks at a multi-regional scale. By considering soil types and background values of elements, the study effectively reduced uncertainties caused by spatial heterogeneity and reached a more quantitative conclusion compared to traditional methods.

JOURNAL OF HAZARDOUS MATERIALS (2023)

Article Engineering, Environmental

Gestational exposure to environmental cadmium induces placental apoptosis and fetal growth restriction via Parkin-modulated MCL-1 degradation

Hua-Long Zhu et al.

Summary: Cadmium induces placental apoptosis and FGR via mtROS-mediated Parkin-modulated degradation of MCL-1.

JOURNAL OF HAZARDOUS MATERIALS (2022)

Article Multidisciplinary Sciences

The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy

Gaojian Zhang et al.

Summary: This study reveals that STX11, a member of the SNARE family primarily expressed in immune cells, regulates lipid metabolism in hepatocytes by binding to ATGL and inhibiting lipid droplet degradation and lipid autophagy. This finding provides new insight into the regulation of hepatic lipid accumulation and related metabolic diseases.

ISCIENCE (2022)

Article Multidisciplinary Sciences

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

Rucha Patel et al.

Summary: In this study, the researchers identified adipose triglyceride lipase (ATGL) as the first biosynthetic enzyme for the formation of the FAHFA ester bond in mammals. They found that ATGL uses transacylase activity to esterify hydroxy fatty acids (HFAs) with fatty acids (FAs) from triglycerides (TGs) or diglycerides (DGs) to produce FAHFAs. The expression of ATGL and the activity of DGAT were found to be closely associated with FAHFA biosynthesis.

NATURE (2022)

Article Engineering, Environmental

Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress

Yong-Wei Xiong et al.

Summary: Cadmium exposure can negatively affect placental angiogenesis and progesterone levels, potentially impairing fetal growth through a mechanism involving GCN-2-mediated mitochondrial stress.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Gestational cadmium exposure impairs placental angiogenesis via activating GC/GR signaling

Xue-Ting Shi et al.

Summary: This study found that melatonin treatment significantly alleviated environmental cadmium-induced placental angiogenesis disorder and reduction of VEGF-A level. Mechanistically, melatonin reversed the downregulation of VEGF-A protein expression induced by environmental cadmium by inhibiting glucocorticoid receptor (GR) activation.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts

Hua-Long Zhu et al.

Summary: The study found that environmental cadmium exposure can lead to fetal growth restriction by activating PERK-regulated placental mitophagy and inhibiting P4 synthesis. Additionally, placental mitophagy is associated with reduced progesterone levels and all-cause fetal growth restriction.

ENVIRONMENT INTERNATIONAL (2021)

Article Environmental Sciences

Autophagy in Sertoli cell protects against environmental cadmium-induced germ cell apoptosis in mouse testes

Guo-Xiang Zhou et al.

Summary: This study revealed that cadmium triggers germ cell apoptosis in the testes, while autophagy in Sertoli cells can alleviate cadmium-induced germ cell apoptosis.

ENVIRONMENTAL POLLUTION (2021)

Article Cell Biology

FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells

Qiang Liu et al.

Summary: This study revealed that FSH stimulates progesterone production in mammalian follicular granulosa cells through a non-canonical pathway, while also promoting the process of autophagy. Moreover, FSH was found to facilitate the degradation of lipid droplets, and inhibiting autophagy led to decreased progesterone production.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Environmental Sciences

Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism

Huihui Hong et al.

Summary: Exposure to cadmium leads to pancreatic beta-cell dysfunction and death, promoting lipid accumulation and altering lipid profiles. The study highlights the role of cadmium in elevating pro-inflammatory lipids and exacerbating diabetes development through insulin secretion dysfunction.

ENVIRONMENT INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts

Hua-Long Zhu et al.

Summary: Gestational exposure to environmental stress can lead to fetal growth restriction (FGR) with reduced levels of melatonin (MT) in the placenta. MT offers protective effects against FGR by inhibiting BNIP3-dependent mitophagy, potentially serving as a therapeutic agent against environmental stress-induced developmental toxicity.

REDOX BIOLOGY (2021)

Article Obstetrics & Gynecology

Placental Compartmentalization of Lipid Metabolism: Implications for Singleton and Twin Pregnancies

Alejandra Abascal-Saiz et al.

Summary: The study found that the maternal side of the placenta is more active in esterification of fatty acids, while storage of neutral lipids primarily occurs on the fetal side. In multiple gestations, there is increased esterification activity without changes in placental triglyceride levels, likely due to greater transfer to the fetal circulation in response to higher energy demand from twin fetuses.

REPRODUCTIVE SCIENCES (2021)

Review Medicine, Research & Experimental

Selective autophagy of intracellular organelles: recent research advances

Wen Li et al.

Summary: Autophagy is a physiological process that degrades over-abundant or damaged organelles via the lysosomal system, induced by stress and occurring in both non-selective and selective manners. Selective autophagy plays a crucial role in maintaining cellular homeostasis and its dysfunction is implicated in various diseases.

THERANOSTICS (2021)

Article Environmental Sciences

Maternal cadmium exposure during late pregnancy causes fetal growth restriction via inhibiting placental progesterone synthesis

Yong-Wei Xiong et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Review Biochemistry & Molecular Biology

Materno-fetal cholesterol transport during pregnancy

Sampada Kallol et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

Review Obstetrics & Gynecology

Physiological and pathological regulation of autophagy in pregnancy

Xiaoxuan Zhao et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2020)

Review Environmental Sciences

Cadmium exposure and risk of breast cancer: A dose-response meta-analysis of cohort studies

Tommaso Filippini et al.

ENVIRONMENT INTERNATIONAL (2020)

Review Immunology

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

Jeffery A. Goldstein et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Cell Biology

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

Micah B. Schott et al.

JOURNAL OF CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

The Flavonoid Quercetin Induces AP-1 Activation in FRTL-5 Thyroid Cells

Cesidio Giuliani

ANTIOXIDANTS (2019)

Article Pathology

Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension

Aiko Aoki et al.

AMERICAN JOURNAL OF PATHOLOGY (2018)

Article Endocrinology & Metabolism

Lipophagy Contributes to Testosterone Biosynthesis in Male Rat Leydig Cells

Yi Ma et al.

ENDOCRINOLOGY (2018)

Review Cell Biology

Autophagy-monitoring and autophagy-deficient mice

Akiko Kuma et al.

AUTOPHAGY (2017)

Article Medicine, Research & Experimental

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

Maria Emilia Solana et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Public, Environmental & Occupational Health

Maternal and cord blood hormones in relation to birth size

Pagona Lagiou et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2014)

Article Multidisciplinary Sciences

Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor

Thomas R. Gawriluk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

Annika Mehlem et al.

NATURE PROTOCOLS (2013)

Article Cell Biology

Oxidative Stress and Mitogen-Activated Protein Kinase Pathways Involved in Cadmium-Induced BRL 3A Cell Apoptosis

Zhang Yiran et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Developmental Biology

The emerging role of mTORC1 signaling in placental nutrient-sensing

T. Jansson et al.

PLACENTA (2012)

Article Chemistry, Analytical

Kidney, liver and bone cadmium content in the western sandpiper in relation to migration

CN McFarland et al.

JOURNAL OF ENVIRONMENTAL MONITORING (2002)