Related references
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Article
Environmental Sciences
Xin Hua et al.
Summary: In this study, we investigated the toxic effect of prolonged exposure to 2-((4-Methylpentan-2-yl)amino)-5-(phenylamino)cyclohexa-2,5-diene-1,4-dione (6-PPDQ) on Caenorhabditis elegans. Results showed that exposure to 100 mu g/L of 6-PPDQ caused lethality, while concentrations of 1-10 mu g/L affected intestinal barrier function, oxidative stress, and antioxidant response. Therefore, long-term exposure to environmentally relevant concentrations of 6-PPDQ may result in intestinal toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Loelia Fohet et al.
Summary: This study investigated the effect of aging on the composition of tire and road wear particles (TRWP). It found that the concentrations of certain chemicals in TRWP changed with different aging conditions, and the longer the aging time, the faster the concentration decreased.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yingyue Zhao et al.
Summary: Multi-walled carbon nanotube (MWCNT), a type of carbon-based nanomaterials, has been widely used in various fields. Exposure to MWCNT in Caenorhabditis elegans can cause toxicity not only in parental generation (P0-G), but also in offspring. However, the underlying mechanisms are still largely unknown.
Article
Engineering, Environmental
Xin Hua et al.
Summary: The potential neurotoxicity of 6-PPDQ after long-term exposure and the underlying mechanism are unclear. In this study, abnormal locomotion behaviors and neurodegeneration of motor neurons were observed in nematodes exposed to 6-PPDQ. The activation of the DEG-3-mediated signaling cascade and the involvement of genes like jnk-1, dbl-1, daf-7, and glb-10 were also identified.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Environmental
Xiaoli Chen et al.
Summary: Tire wear compounds 6PPD and its derivative 6PPD-quinone, considered as emerging pollutants, have been found to be ubiquitous in the environment. Current studies mainly focus on their occurrence in dust and water, while limited information is available about their presence in atmosphere, soil, sediments and organisms. Although they have potential adverse effects on aquatic organisms, the toxicological mechanisms of these compounds are still unclear.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Xin Hua et al.
Summary: Nanoplastics in the environment can pose ecological and health risks. This study focused on the transgenerational toxicity of polystyrene nanoparticles (PS-NP) and the role of germline fibroblast growth factor (FGF) signal in mediating this toxicity. The exposure to PS-NP induced an increase in expression of germline FGF ligand/EGL-17 and LRP-1, and RNAi interference of these genes resulted in resistance to transgenerational PS-NP toxicity. In addition, overexpression of EGL-17 increased the expression of FGF receptor/EGL-15 in the offspring, and RNAi interference of egl-15 inhibited transgenerational toxicity in animals overexpressing germline EGL-17. The results highlight the important role of germline FGF signal activation in mediating transgenerational toxicity induced by nanoplastics.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Xin Hua et al.
Summary: The reproductive toxicity of 20 nm polystyrene nanoparticles (PS-NP) in Caenorhabditis elegans was investigated, and it was found that PS-NP exposure reduced reproductive capacity and induced DNA damage-induced germline apoptosis. Treatment with paeoniflorin had a protective effect on reproductive capacity and reduced germline apoptosis and DNA damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Wenmiao He et al.
Summary: Recently, the transgenerational toxicity of nanoplastics, particularly sulfonate-modified polystyrene nanoparticles (PS-S NP), has gained attention. Using Caenorhabditis elegans as a model, researchers investigated the transgenerational effects of PS-S NP on locomotion behavior and reproductive capacity. They found that exposure to PS-S NP caused transgenerational inhibition in these traits and that the underlying mechanisms involved the activation of germline Notch signal mediated by LAG-2 and GLP-1 in the nematodes.
Article
Environmental Sciences
Bonnie P. Lo et al.
Summary: The breakdown product of a rubber tire antioxidant has been found to cause toxic injury and death in coho salmon. Coho salmon are more sensitive to this product compared to Chinook salmon. This research highlights the importance of protecting Chinook salmon and their habitat.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Environmental Sciences
Mingfeng Tang et al.
Summary: This study investigated the possible effect of polystyrene nanoparticles on the toxicity of Acinetobacter johnsonii infection in Caenorhabditis elegans. The results showed that exposure to polystyrene nanoparticles enhanced the toxicity of bacterial infection on lifespan and locomotion behaviors in the nematodes. It also increased the accumulation of bacteria in the body of the nematodes and suppressed the innate immune response. Therefore, the study suggests a potential risk of nanoplastic in enhancing the toxic effects of bacterial pathogens on environmental organisms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Yuxing Wang et al.
Summary: Exposure to 6-PPDQ leads to lipid accumulation and inhibition of fatty acid β-oxidation in Caenorhabditis elegans. This lipid accumulation is associated with increased fatty acid synthesis and increased synthesis of monounsaturated fatty acylCoAs. Additionally, metabolic sensors sbp-1 and mdt-15 are upregulated in response to 6-PPDQ exposure.
ENVIRONMENTAL POLLUTION
(2023)
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Engineering, Environmental
Xin Hua et al.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Xin Hua et al.
Summary: Recently, the possible reproductive toxicity of 6-PPDQ, a derivative of tire antioxidant 6-PPD, was investigated in Caenorhabditis elegans. Exposure to 1 and 10 µg/L 6-PPDQ reduced reproductive capacity and enhanced germline apoptosis. These effects were associated with DNA damage, altered gene expressions, and changes in the cell corpse engulfment process.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
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Chemistry, Medicinal
Le Zhang et al.
Summary: Paeoniflorin, the major active compound of total glycoside of paeony, can effectively inhibit the immunosuppression induced by bacterial pathogen infection in Caenorhabditis elegans.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Environmental Sciences
Wenmiao He et al.
Summary: This study aimed to systematically assess the toxicity of 6-PPDQ on multiple organs in mice. The results showed that repeated injection of 6-PPDQ induced toxic effects on multiple organs in mice, while single injection did not show significant toxicity effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yuxing Wang et al.
Summary: Using Caenorhabditis elegans as a model organism, this study investigated the combinational effect of 2-hydroxyatrazine and polystyrene nanoparticle on the function and development of D-type motor neurons. The results showed that exposure to 2-hydroxyatrazine alone led to decreased motor function and neurodegeneration. Combinational exposure with polystyrene nanoparticle enhanced the toxic effects on motor function and increased the expression of genes related to neurodegeneration. Therefore, this study demonstrated that 2-hydroxyatrazine and nanoplastics can have toxic effects on the nervous system at environmentally relevant concentrations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yuting Shao et al.
Review
Environmental Sciences
Stephan Wagner et al.
Summary: The study reviews the aging impact on tire and road wear particles (TRWPs) and environmental aging processes, discusses experimental and analytical techniques for simulating and determining aging changes, and elaborates on next steps for research on TRWP aging in the environment.
Article
Engineering, Environmental
Cassandra Rauert et al.
Summary: Tire road wear particles are a significant source of microplastics in urban environments, and they also facilitate the release of additive chemicals into the environment. Stormwater plays a major role in transporting both tire wear particles and additives to urban surface water. During severe storm events, the concentration of additives increased more than 40 times, and there was a strong correlation between the concentrations of tire wear particles and all additives.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
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Biochemistry & Molecular Biology
Haelim Jeong et al.
Summary: The discovery of rcat-1 as a novel negative transcriptional regulator for dopamine metabolism genes has provided insights into the regulation of food search-associated locomotion. The mutants of rcat-1 exhibit abnormal movement behaviors and potential deficiencies in food sensing or locomotion toward food. This finding not only identifies a new subtype of dopamine-related behaviors but also suggests a potential therapeutic target in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
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Shubham Varshney et al.
Summary: The study found that 6PPD quinone is toxic to zebrafish larvae, but no significant mortality was observed at the tested concentrations, resulting in a dose-dependent reduction in swimming performance. Exposure to environmentally relevant concentrations (1 µg/L) of 6PPD and 6PPD quinone did not affect the behavior of zebrafish embryos, while exposure to higher but sublethal concentrations (10 and 25 µg/L) can impact behavioral endpoints.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Engineering, Environmental
Zhenyu Tian et al.
Summary: Stormwater exposure can lead to acute mortality of coho salmon, with 6PPD-quinone identified as the primary toxicant. Analysis of commercial standards of 6PPDQ revealed a high bias in prior reporting. This study re-confirmed toxicity estimates using a commercial standard and developed a quantification method. The results showed higher responses with the commercial standard and a significantly lower LC50 value compared to previous reports, highlighting the substantial lethality of 6PPD-Q.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Kaiming Yang et al.
Summary: Tire wear particles (TWPs) have been identified as microplastics and may have adverse effects on marine organisms. This study analyzed the chemical composition of TWPs and their leachate, identifying various organic compounds and metals. Toxicity identification evaluation revealed that zinc was the main toxicant in the TWP leachate. Additionally, the release of zinc from TWPs into the aquatic environment was found to be slow.
Article
Engineering, Environmental
Guodong Cao et al.
Summary: The study found that rubber-derived quinones are widely present in urban environments and are closely related to human activities. One of the identified quinones was found to be highly toxic to coho salmon. Mass spectrometry and liquid chromatography-mass spectrometry were used to investigate the distribution and concentration of these compounds. The results showed that the quinones had distinct distribution and concentration patterns in different environments. The estimated daily intake of these compounds by the population in Hong Kong exceeded the exposure levels of their parent compounds. Therefore, further toxicological studies are recommended to explore the potential ecological and human health risks of these newly discovered quinones.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Bettina Seiwert et al.
Summary: The study investigated the abiotic oxidative transformation of 6-PPD and its presence in different environmental compartments. The results showed that most of these transformation products will enter water bodies with road runoff, and suggestions were made to reduce the emission of 6-PPD and its TPs.
Article
Engineering, Environmental
Markus Brinkmann et al.
Summary: N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-quinone), a transformation product of the rubber tire antioxidant 6PPD, has been identified as the chemical responsible for urban runoff mortality syndrome in coho salmon. This study investigated the acute toxicity of 6PPD-quinone to rainbow trout, brook trout, Arctic char, and white sturgeon. Results showed that rainbow trout and brook trout were more sensitive to the chemical, while Arctic char and white sturgeon were less affected.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Xiaojuan Zhang et al.
Summary: In this study, the neurobehavioral toxicity effects of Fumonisin B1 (FB1) on Caenorhabditis elegans were investigated. FB1 caused dose- and time-dependent behavioral defects and damaged GABAergic and serotonergic neurons. The relative content of GABA and serotonin decreased significantly and abnormal expression of mRNA levels associated with GABA and serotonin were found. The neurobehavioral toxicity effect of FB1 may be mediated by abnormal neurotransmission of GABA and serotonin. This study provides important information for understanding the neurotoxicity of FB1.
ENVIRONMENTAL POLLUTION
(2022)
Article
Plant Sciences
Yusong Liu et al.
Summary: Exogenous dopamine and overexpression of MdTyDC enhance apple resistance to Fusarium solani, reduce root damage, and improve plant growth and metabolism.
Article
Environmental Sciences
Yue Zhao et al.
Summary: In this study, researchers identified the Ephrin ligand EFN-3 as a target of the kinase suppressors of Ras (KSR-1/2) in the germline of Caenorhabditis elegans. They found that exposure to polystyrene nanoparticles (PS-NPs) at predicted environmental concentrations induced an increase in EFN-3 expression in the germline of parental generations and this increase was also observed in the offspring. The activation of EFN-3 in the germline mediated transgenerational PS-NP toxicity, and the activation of its receptor VAB-1 in the offspring further contributed to the toxicity. The researchers concluded that germline Ephrin signals play an important role in mediating transgenerational toxicity of nanoplastics.
Article
Engineering, Environmental
Hannah Mahoney et al.
Summary: N-(1,3-Dimethylbutyl)-N-phenyl-p-phenylenediamine-quinone (6PPD-quinone) is highly toxic to certain salmonids and may affect respiration. In vitro experiments showed that 6PPD-quinone can uncouple mitochondrial respiration in fish cells, leading to decreased cell viability and increased oxygen consumption rate.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Environmental Sciences
Cassandra Johannessen et al.
Summary: In this study, the presence of 29 chemicals derived from tire wear in wastewater treatment plants and drinking water treatment plants was monitored. The results showed that these compounds had different concentrations and quantities in influents and effluents, indicating that both types of treatment plants may serve as sinks and sources of these substances.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2022)
Review
Environmental Sciences
Hui Li et al.
Summary: This review summarizes the existing studies using Caenorhabditis elegans as a model organism to explore the multi/transgenerational toxicity and potential molecular mechanisms induced by environmental pollutants. It discusses the various biological defects induced by parental and successive exposure to environmental pollutants, including developmental toxicity, neurotoxicity, reproductive toxicity, and metabolic disturbances, which may be transmitted to progeny through reactive oxygen species-induced damage, epigenetic mechanisms, and insulin/insulin-like growth factor-1 signaling pathway.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Jiawen Ji et al.
Summary: This study investigated the toxic effects of 6PPD and its metabolites on adult zebrafish using machine vision. Abnormal behaviors induced by 6PPD and its metabolites were observed and analyzed using meandering, body angle, top time, and 3D trajectory. Changes in neurotransmitters were also measured to explore the causes of abnormal behavior. The study provides important insights into the biological toxicity of 6PPD and its metabolites.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Zhenyu Tian et al.
Summary: Research on coho salmon in the U.S. Pacific Northwest revealed unexpected risks of a highly toxic quinone transformation product of the tire rubber antioxidant 6PPD. This implies toxicological relevance for burned-off tire rubber residues to aquatic species.
Review
Cell Biology
Gregory G. Fuller et al.
Summary: Under hypoxic conditions, glycolysis becomes the primary metabolic pathway due to TCA cycle inhibition, but mechanisms compensating for the resulting decrease in energy production are not well understood. Recent studies show dynamic compartmentalization of glycolysis enzymes in response to hypoxic stress in yeast, C. elegans, and mammalian cells. Concentrating glycolysis enzymes into condensates may enhance glucose utilization and energy production.
JOURNAL OF CELL SCIENCE
(2021)
Article
Engineering, Environmental
Haibo Chen et al.
Summary: Chronic exposure to aged polystyrene microplastics (PS-MPs) may cause more severe neurotoxicity compared to virgin PS-MPs, affecting dopamine, glutamate, and serotonin neurotransmission. These findings highlight the potential risks of aged microplastics on the neural systems of organisms.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Cell Biology
Luisa Speranza et al.
Summary: Dopamine is a key neurotransmitter involved in various physiological functions such as motor control, emotional regulation, reward mechanisms, and cognitive functions. Dysfunction in dopamine transmission is linked to devastating neurological and psychiatric disorders like Parkinson's disease and schizophrenia. Additionally, dopamine plays a crucial role in regulating synaptic dynamics, synaptic plasticity, and dendritic spines.
Article
Engineering, Environmental
Philipp Kloeckner et al.
Summary: This study identified three organic compounds as suitable quantitative markers for TRWPs through non-target screening and liquid-chromatography high-resolution mass spectrometry identification. These compounds showed a linear response in standard addition experiments and were correlated with TRWP contents in environmental samples, suggesting their potential as markers for TRWP quantification. The use of organic markers would allow for easy quantification of TRWPs with traditional tandem MS equipment in organic trace analytical laboratories, facilitating data generation on TRWP occurrence in various environmental matrices.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
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Engineering, Environmental
Kyoshiro Hiki et al.
Summary: The study revealed that 6PPD quinone did not exhibit acute lethal toxicity to freshwater fish and crustacean species. This suggests that the urban runoff toxicity observed could be attributed to other chemicals. Further research is needed to understand the underlying mechanisms of the observed difference in toxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Engineering, Environmental
J. K. Challis et al.
Summary: Recent findings show that 6PPD-quinone, a transformation product of a common tire rubber antioxidant, is acutely toxic in stormwater-impacted streams. This study in Saskatoon, Canada detected 6PPD-quinone and other tire rubber-derived compounds in stormwater and snowmelt, with DPG being the most abundant. High concentrations of DPG and 6PPD-quinone were found and correlated with roads and residential land-use area.
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