Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 7, Pages 1371-1374Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08717h
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Funding
- DST New Delhi
- DRDO New Delhi
- DAE-BRNS Mumbai
- IISER Bhopal
- UGC-CSIR
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A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp(3))-H and N-H bonds utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110-140 degrees C.
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