4.7 Article

A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 12, Pages 2407-2410

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09416f

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Funding

  1. National Research Foundation (NRF) - Korean Government [2012R1A2A1A03670456]
  2. Basic Science Research Program through the NRF [2012R1A1A2006259]

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We report a two-photon fluorescent probe for ratiometric imaging of cysteamine in situ. This probe can detect the levels of endogenous cysteamine with statistical significance in live cells and brain hippocampal tissues, revealing that cysteamine is localized mainly in the perikaria of the pyramidal neurons and the granule cells.

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