Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver

Article Agriculture, Multidisciplinary

Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis

Xixi Wang et al.

Summary: It has been found that PFOS causes cardiac toxicity and CBD can attenuate the PFOS-induced heart injury, providing a novel cardioprotective strategy.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Environmental Sciences

Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS

Luyun Liang et al.

Summary: This article reviewed the effects of PFOA and PFOS on immune organs and functions, as well as the possible immune toxicity mechanisms.

CHEMOSPHERE (2022)

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Article Engineering, Environmental

Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish

Honghong Chen et al.

Summary: Perfluorooctane sulfonamide (PFOSA), a precursor of perfluorooctanesulfonate (PFOS), is widely used in industrial processes. This study found that PFOSA has toxic effects on aquatic organisms, specifically affecting the development and function of the heart. The results also suggest a significant role of the aryl hydrocarbon receptor (AHR) in PFOSA-induced cardiotoxicity.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

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Article Engineering, Environmental

Comparative chronic toxicities of PFOS and its novel alternatives on the immune system associated with intestinal microbiota dysbiosis in adult zebrafish

Jing Huang et al.

Summary: The exposure to PFOS and its alternatives F-53B and OBS can induce hepatic immunotoxicity and disrupt the intestinal microbiota in adult zebrafish, causing oxidative stress and anti-inflammatory effects in the liver, as well as changes in intestinal microbiota composition and function.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Environmental Sciences

Spatially revealed perfluorooctane sulfonate-induced nephrotoxicity in mouse kidney using atmospheric pressure MALDI mass spectrometry imaging

Yanyan Chen et al.

Summary: This study used AP-MALDI MSI to reveal the spatial distributions of PFOS in mouse kidneys and its adverse effects on lipid metabolism. PFOS was found to accumulate mainly in the renal pelvis and outer cortex regions, causing damage to the kidneys. Significant down-regulation of certain lipids and up-regulation of others were observed in different regions of the kidneys between control and PFOS-exposed mice.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Review Biology

Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review

Camren G. Heider et al.

Summary: This review examines recent studies on the efficacy and mechanisms of CBD as a cancer treatment. Findings suggest that CBD can relieve cancer pain and alleviate chemotherapy side effects, mainly through its interaction with the endocannabinoid system. Further research on the anticancer effects of CBD is needed.

BIOLOGY-BASEL (2022)

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Review Environmental Sciences

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Pingwei Wang et al.

Summary: This study reviews the adverse effects of PFOS on liver tissue and function, providing a reference for further research on the toxicity of PFOS and liver injury caused by PFOS.

TOXICS (2022)

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Article Engineering, Environmental

Microplastics released from food containers can suppress lysosomal activity in mouse macrophages

Jingyu Deng et al.

Summary: The ingestion and accumulation of microplastics, released from plastic food containers, pose a serious threat to human health and ecosystem. In vitro experiments demonstrated that both micro- and nanoplastics are readily taken up by cells, leading to inflammation and suppression of lysosomal activities. The widespread use of plastic packaging presents significant health risks to consumers.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Prediction of Aflatoxin-B1 (AFB1) Molecular Mechanism Network and Interaction to Oncoproteins Growth Factor in Hepatocellular Carcinoma

Yulanda Antonius et al.

Summary: In this study, bioinformatics tools were used to identify proteins that may interact with AFB1 in HCC and predict the pathways affected by AFB1. The results showed that kinases, phosphatases, and G protein-coupled receptors were potential targets of AFB1, with seven kinase proteins strongly related to HCC. Reverse docking analysis revealed that the AKT1-AFB1 complex had the lowest affinity score and was associated with the metastasis pathway in HCC mechanism.

JOURNAL OF PURE AND APPLIED MICROBIOLOGY (2022)

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Article Environmental Sciences

Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-?B/NLRP3 pathway

Yujiao He et al.

Summary: The widespread occurrence of nanoplastics has become a global threat to animals and human health. This study explores the impact of polystyrene nanoparticles (PSNPs) on the intestinal barrier and inflammation, and identifies the molecular mechanism involving the ROS drived-NF-kappa B/NLRP3 pathway.

CHEMOSPHERE (2022)

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Article Engineering, Environmental

Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation

Qianru Chi et al.

Summary: The use of plastics and nanotechnology has brought convenience to our lives, but it also increases the environmental burden and the risk of exposure to nanoparticles. This study reveals that exposure to polystyrene nanoparticles (PSNPs) leads to neutrophil infiltration and neutrophil extracellular trap (NET) formation in the liver. Further research shows that NET formation is associated with the reactive oxygen species (ROS)-NLRP3 axis. Inhibition of ROS and NLRP3 can alleviate PSNP-induced NET formation. Moreover, the use of DNase I-coated PSNPs can disassemble NET, reduce neutrophil infiltration in the liver, inhibit the ROS-NLRP3 axis, and decrease cytokine expression.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Engineering, Environmental

Phthalate-induced testosterone/androgen receptor pathway disorder on spermatogenesis and antagonism of lycopene

Yi Zhao et al.

Summary: Male infertility is a significant concern due to the decline in sperm quality worldwide. Phthalates, particularly DEHP or its metabolite MEHP, have negative effects on male reproductive development and function, leading to reduced fertility. Lycopene, a natural antioxidant, has the potential to be used as a therapeutic option for male infertility. This research demonstrates that DEHP reduces testosterone production in Leydig cells and impairs secretory function in Sertoli cells, resulting in impaired spermatogenesis. Additionally, MEHP causes mitochondrial and oxidative damage, posing a serious threat to spermatogenesis. However, LYC supplementation reverses these changes. Mechanistically, DEHP disrupts the T/AR signaling pathway, contributing to male infertility. Overall, this study highlights the critical role of the T/AR signal transduction in male fertility and provides promising insights into the protective role of LYC in phthalate-induced male reproductive disorders.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Environmental Sciences

Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice?

Hao Wu et al.

Summary: Microplastics can induce uterine fibrosis in female mice by triggering oxidative stress and activating the Notch and TGF-f3 signaling pathways through the TLR4/NOX2 signaling axis. Inhibition of the TLR4/NOX2 signaling pathway can reduce the expression of fibrotic genes, suggesting it as a potential therapeutic option to alleviate the reproductive toxicity of microplastics.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity

Zijie Li et al.

Summary: Previous studies have shown that PFOS exposure affects male reproduction by disrupting the blood-testis barrier and spermatogenesis. This study further demonstrates that PFOS has systematic effects on male fertility, including decreased LH/LHr function, reduced epididymal sperm motility, and alteration of gene expression related to sperm motility and steroidogenesis. It also activates brain nuclei associated with anxiety-like behaviors and perturbs the hypothalamic metabolome.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

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Article Environmental Sciences

Aquatic toxicity evaluations of PFOS and PFOA for five standard marine endpoints

Nicholas T. Hayman et al.

Summary: The study evaluated the toxicity of PFOS and PFOA on four marine testing species and found the sensitivity ranking of M. galloprovincialis, S. purpuratus, P. lunula, and A. bahia. The results suggest that these species and endpoints are sensitive to PFAS, making them suitable for deriving toxicity data for other PFAS in marine ecosystems.

CHEMOSPHERE (2021)

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Article Environmental Sciences

Hydrogen sulfide of air induces macrophage extracellular traps to aggravate inflammatory injury via the regulation of miR-15b-5p on MAPK and insulin signals in trachea of chickens

Nuan Song et al.

Summary: The study investigated the effects of H2S exposure on chicken trachea, revealing airway injury and METs release. The results indicate that H2S mediates the release of METs through miRNA-156-5p targeting ATF2, leading to tracheal inflammatory injury.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Cell Biology

Eosinophil extracellular traps drive asthma progression through neuro-immune signals

Yiwen Lu et al.

Summary: It has been found that Eosinophil extracellular traps (EETs) in bronchoalveolar lavage fluid are associated with the severity of asthma in patients. EETs augment inflammation and activate pulmonary neuroendocrine cells, exacerbating allergic immune responses in non-infection-related asthma. Therapeutically, inhibition of CCDC25 can alleviate allergic inflammation.

NATURE CELL BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Macrophage extracellular traps aggravate iron overload-related liver ischaemia/reperfusion injury

Shan Wu et al.

Summary: Macrophage extracellular traps and ferroptosis play significant roles in liver ischemia/reperfusion injury, with potential therapeutic implications for inhibiting these pathways to reduce liver damage.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis

Qianru Chi et al.

Summary: Selenium deficiency induces arteritis by reducing SelS levels and promotes disease progression by regulating neutrophil recruitment and NET formation. The formation of NETs in arteritis is dependent on ROS bursts and the PPAR pathway. Silencing SelS exacerbates arteritis through its effects on NET formation.

REDOX BIOLOGY (2021)

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Article Environmental Sciences

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

Ran Jin et al.

ENVIRONMENT INTERNATIONAL (2020)

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Review Gastroenterology & Hepatology

Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis

Michitaka Matsuda et al.

SEMINARS IN LIVER DISEASE (2020)

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Article Environmental Sciences

Intestinal environmental disorders associate with the tissue damages induced by perfluorooctane sulfonate exposure

Gang Wang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Article Multidisciplinary Sciences

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Linbin Yang et al.

NATURE (2020)

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Editorial Material Gastroenterology & Hepatology

NETs promote liver metastasis via CCDC25

Iain Dickson

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Chemistry, Medicinal

Mono-(2-ethylhexyl) Phthalate Aggravates Inflammatory Response via Sirtuin Regulation and Inflammasome Activation in RAW 264.7 Cells

Min Hi Park et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2019)

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Article Environmental Sciences

Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China

Min Nian et al.

ENVIRONMENTAL RESEARCH (2019)

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Article Medicine, General & Internal

Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells

Le Wang et al.

EBIOMEDICINE (2019)

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Review Pharmacology & Pharmacy

Therapeutic Prospects of Cannabidiol for Alcohol Use Disorder and Alcohol-Related Damages on the Liver and the Brain

Julia De Ternay et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Fisheries

The PFOS disturbed immunomodulatory functions via nuclear Factor-κB signaling in liver of zebrafish (Danio rerio)

Jinshu Guo et al.

FISH & SHELLFISH IMMUNOLOGY (2019)

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Review Environmental Sciences

A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects

Elsie M. Sunderland et al.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2019)

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Review Immunology

Macrophage Extracellular Traps: A Scoping Review

Ryan S. Doster et al.

JOURNAL OF INNATE IMMUNITY (2018)

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Article Environmental Sciences

Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-κB/TNF-α/IL-6-dependent pathway

Rui Han et al.

CHEMOSPHERE (2018)

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Article Environmental Sciences

Simultaneous determination of (N-ethyl perfluorooctanesulfonamido ethanol)-based phosphate diester and triester and their biotransformation to perfluorooctanesulfonate in freshwater sediments

Shiyi Zhang et al.

ENVIRONMENTAL POLLUTION (2018)

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Article Biochemistry & Molecular Biology

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Koshu Okubo et al.

NATURE MEDICINE (2018)

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Article Neurosciences

Perfluorooctane sulfonate mediates secretion of IL-1β through PI3K/AKT NF-κB pathway in astrocytes

Xiaoxu Chen et al.

NEUROTOXICOLOGY AND TERATOLOGY (2018)

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Article Environmental Sciences

Estrogen receptor beta mediates hepatotoxicity induced by perfluorooctane sulfonate in mouse

Cheng Xu et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Apoptotic gene expression profiles and DNA damage levels in rat liver treated with perfluorooctane sulfonate and protective role of curcumin

Dilek Eke et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Article Food Science & Technology

Perfluorooctane sulfonate blocked autophagy flux and induced lysosome membrane permeabilization in HepG2 cells

Xiao-Feng Yao et al.

FOOD AND CHEMICAL TOXICOLOGY (2014)

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Article Immunology

Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis

Ka-Wing Wong et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

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Article Immunology

Identification of macrophage extracellular trap-like structures in mammary gland adipose tissue: a preliminary study

Sunish Mohanan et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Article Immunology

Mannheimia haemolytica and Its Leukotoxin Cause Macrophage Extracellular Trap Formation by Bovine Macrophages

Nicole A. Aulik et al.

INFECTION AND IMMUNITY (2012)

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Article Biochemistry & Molecular Biology

Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

Partha Mukhopadhyay et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

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Article Cell Biology

Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis

M. P. Lim et al.

CELL DEATH & DISEASE (2011)

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Article Microbiology

Statins Enhance Formation of Phagocyte Extracellular Traps

Ohn A. Chow et al.

CELL HOST & MICROBE (2010)

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Article Cell Biology

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Venizelos Papayannopoulos et al.

JOURNAL OF CELL BIOLOGY (2010)

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Article Gastroenterology & Hepatology

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

Yan Wang et al.

JOURNAL OF HEPATOLOGY (2010)

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Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver

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