Nephroprotective effects of Acacia senegal against aflatoxicosis via targeting inflammatory and apoptotic signaling pathways

Article Engineering, Environmental

Production and Characterization of Sodium Alginate/Gum Arabic Based Films Enriched with Syzygium cumini Seeds Extracts for Food Application

Mohamed Abdin et al.

Summary: The study investigated the effects of incorporating Syzygium cumini seeds extract (SCSE) into sodium alginate/gum Arabic (SG) films, showing that SCSE addition can enhance antioxidant activity and extend the shelf life of oil products.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2022)

Add to Collection

Article Environmental Sciences

Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver

Sihong Li et al.

Summary: This study aimed to evaluate the mitigative effects of curcumin on AFB1-induced necroptosis and inflammation in chicken liver. The results showed that AFB1 exposure led to necrotic characteristics and inflammation in chicken livers, increased oxidative stress and decreased antioxidant activity in liver tissue. Curcumin regulated the TLR4/RIPK signaling pathway, reduced oxidative stress biomarkers and inflammatory cytokines levels, and attenuated necroptosis and inflammation in chicken liver tissue.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Add to Collection

Article Environmental Sciences

Dietary phillygenin supplementation ameliorates aflatoxin B1-induced oxidative stress, inflammation, and apoptosis in chicken liver

Jing Guo et al.

Summary: This research aimed to investigate the preventive effects of Phillygenin (PHI) on the toxicity of Aflatoxin B-1 (AFB(1)) in the liver of chickens. Results revealed that dietary PHI ameliorated liver function indicators, reduced oxidative damage and inflammatory response, decreased apoptosis, and increased antioxidant enzyme contents by inhibiting NF-kappa B and activating the Nrf2 signaling pathway. This study provides new insight into the therapeutic uses of PHI.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Add to Collection

Article Oncology

Antioxidant and Antigenotoxic Actions of Gum Arabic on the Intestinal Mucosa, Liver and Bone Marrow of Swiss Mice Submitted to Colorectal Carcinogenesis

Andre Luis Nunes Avelino et al.

Summary: Gum arabic shows potential in inhibiting colorectal carcinogenesis by reducing the formation of aberrant crypts and decreasing genotoxicity and oxidative stress in the colon, liver, and systemic levels. These results suggest a promising role for gum arabic as an antioxidant in the development of treatments for colorectal cancer.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)

Add to Collection

Review Nutrition & Dietetics

Short-chain fatty acids as anti-inflammatory agents in overweight and obesity: a systematic review and meta-analysis

Shaun Eslick et al.

Summary: The study found that short-chain fatty acids and prebiotic interventions can reduce systemic inflammation biomarkers associated with obesity, supporting their use as novel aids in treating obesity-related systemic inflammation.

NUTRITION REVIEWS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting Akt/NF-κB/p53 Pathway and Apoptosis Inducing Potential of 1,2-Benzenedicarboxylic Acid, Bis (2-Methyl Propyl) Ester Isolated from Onosma bracteata Wall. against Human Osteosarcoma (MG-63) Cells

Ajay Kumar et al.

Summary: The study investigates the potential of BDCe fraction in inhibiting the proliferation of osteosarcoma cells and inducing apoptosis. The BDCe fraction shows chemopreventive properties by inhibiting the cell cycle and inducing apoptosis through the Akt/NF-kappa B/p53 pathways.

MOLECULES (2022)

Add to Collection

Article Multidisciplinary Sciences

Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney derangement in rats

Solomon E. Owumi et al.

Summary: This study found that extracts from Sorghum bicolor plant have potential cytotoxic effects on cancer cells and can ameliorate hepatorenal injuries caused by aflatoxin. The extracts also showed inhibitory effects on oxidative stress, inflammation, and apoptosis, and protected the liver and kidney tissues. These findings suggest the potential of these extracts for cancer therapy and prevention of aflatoxin-related health issues.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Food Science & Technology

Evaluation of Growth Performance, Nitrogen Balance and Blood Metabolites of Mutton Sheep Fed an Ammonia-Treated Aflatoxin B1-Contaminated Diet

Meimei Zhang et al.

Summary: The study found that ammonia treatment has the potential to decrease the concentration of aflatoxin B1 (AFB1) and alleviate its adverse effects on sheep.

TOXINS (2022)

Add to Collection

Article Agriculture, Dairy & Animal Science

Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks

Xinxin Gao et al.

Summary: The study demonstrated that morin has a protective effect on AFB1-induced liver and kidney damage in chicks by inhibiting HETs release, regulating oxidative stress, and inhibiting inflammatory response.

POULTRY SCIENCE (2021)

Add to Collection

Article Environmental Sciences

Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats

Mohamed M. Abdel-Daim et al.

Summary: This study evaluated the ameliorative effect of fucoidan on AFB(1)-induced hepatorenal toxicity in rats. The results suggest that fucoidan alleviates cell damage and oxidative stress induced by AFB(1), possibly due to its antioxidant and anti-apoptotic activities.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Add to Collection

Article Environmental Sciences

Toxicogenicity and mechanistic pathways of aflatoxin B1 induced renal injury

Nomali Zanele Dlamini et al.

Summary: The study investigated the toxic effects of AFB(1) on human renal cells, revealing that oxidative stress induced by AFB(1) leads to cell death through the intrinsic pathway of apoptosis. While an increase in free radicals was observed, upregulation of antioxidant systems prevented membrane damage and necrosis, indicating activation of defense mechanisms. Contrary to expectations, AFB(1) treatment did not result in phosphatidylserine externalization, a key hallmark of apoptosis.

ENVIRONMENTAL TOXICOLOGY (2021)

Add to Collection

Review Oncology